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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gab1
growth factor receptor bound protein 2-associated protein 1
MGI:108088
52 phenotypes from 8 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gab1tm1Ajw/Gab1tm1Ajw
involves: 129X1/SvJ * C57BL/6 		abnormal cardiovascular system morphology J:83953
abnormal extraembryonic tissue morphology J:83953
lethality throughout fetal growth and development, complete penetrance J:83953
Gab1tm1Gsf/Gab1tm1Gsf
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal glucose homeostasis J:98318
abnormal lipid homeostasis J:98318
decreased circulating free fatty acids level J:98318
decreased circulating glucose level J:98318
decreased circulating insulin level J:98318
decreased circulating triglyceride level J:98318
decreased glycogen level J:98318
improved glucose tolerance J:98318
increased insulin sensitivity J:98318
Gab1tm1Thir/Gab1tm1Thir
involves: C57BL/6 		abnormal epidermis stratum granulosum morphology J:61790
abnormal hair follicle development J:61790
absent eyelids J:61790
decreased embryo size J:61790
decreased trophoblast giant cell number J:61790
dilated heart left ventricle J:61790
dilated heart right ventricle J:61790
early eyelid opening J:61790
hemopericardium J:61790
hemorrhage J:61790
lethality throughout fetal growth and development, complete penetrance J:61790
petechiae J:61790
placental labyrinth hypoplasia J:61790
small placenta J:61790
thin epidermis J:61790
thin ventricular wall J:61790
ventricular hypoplasia J:61790
Gab1tm1Wbm/Gab1+
involves: 129P2/OlaHsd * C57BL/6 		abnormal behavior J:68751
postnatal lethality, incomplete penetrance J:68751
Gab1tm1Wbm/Gab1tm1Wbm
involves: 129P2/OlaHsd 		abnormal intrinsic tongue muscle morphology J:100909
abnormal muscle precursor cell migration J:100909
hypaxial muscle hypoplasia J:100909
Gab1tm1Wbm/Gab1tm1Wbm
involves: 129P2/OlaHsd * C57BL/6 		abnormal diaphragm development J:68751
abnormal hair follicle development J:68751
abnormal keratinocyte physiology J:68751
abnormal muscle precursor cell migration J:68751
abnormal placenta labyrinth morphology J:68751
abnormal placenta vasculature J:68751
decreased liver weight J:68751
decreased trophoblast giant cell number J:68751
disorganized placental labyrinth J:68751
fetal growth retardation J:68751
hypaxial muscle hypoplasia J:68751
lethality throughout fetal growth and development, complete penetrance J:68751
thin epidermis J:68751
thin placenta labyrinth J:68751
Gab1tm1Wbm/Gab1tm1Wbm
involves: 129P2/OlaHsd * C57BL/6 * CD-1 		abnormal skeletal muscle morphology J:125303
cleft secondary palate J:125303
decreased skeletal muscle mass J:125303
Gab1tm2Wbm/Gab1tm2Wbm
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1 		abnormal placenta labyrinth morphology J:125303
cleft secondary palate J:125303
decreased liver weight J:125303
lethality throughout fetal growth and development, complete penetrance J:125303
normal muscle phenotype J:125303
palatal shelves fail to meet at midline J:125303
Gab1tm2Wbm/Gab1tm3Wbm
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1 		decreased liver weight J:125303
disorganized placental labyrinth J:125303
thin placenta labyrinth J:125303
Gab1tm3Wbm/Gab1tm3Wbm
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1 		cleft secondary palate J:125303
decreased liver weight J:125303
disorganized placental labyrinth J:125303
lethality throughout fetal growth and development, complete penetrance J:125303
normal muscle phenotype J:125303
palatal shelves fail to meet at midline J:125303
thin placenta labyrinth J:125303
Gab1tm4Wbm/Gab1tm4Wbm
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1 		eyelids open at birth J:125303
impaired wound healing J:125303
Gab1tm5Wbm/Gab1tm5Wbm
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1 		abnormal cell migration J:125303
abnormal muscle precursor cell morphology J:125303
abnormal myogenesis J:125303
disorganized placental labyrinth J:125303
embryonic lethality during organogenesis, incomplete penetrance J:125303
thin placenta labyrinth J:125303
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory