69 phenotypes from 6 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nkx2-1tm1Jaw/Nkx2-1tm1Jaw B6.129-Nkx2-1tm1Jaw	abnormal lung morphology	J:169693
	abnormal thyroid gland development	J:169693
	neonatal lethality, complete penetrance	J:169693
	respiratory failure	J:169693
Nkx2-1tm1Jaw/Nkx2-1tm1Jaw involves: 129S2/SvPas * CD-1	abnormal branching involved in lung morphogenesis	J:85424
	abnormal lung saccule morphology	J:85424
	abnormal lung vasculature morphology	J:85424
	abnormal mesenchymal cell differentiation involved in lung development	J:85424
	abnormal pulmonary acinus morphology	J:85424
	abnormal pulmonary alveolus epithelial cell morphology	J:85424
	dilated respiratory conducting tube	J:85424
	impaired branching involved in respiratory bronchiole morphogenesis	J:85424
	neonatal lethality, complete penetrance	J:85424
	pulmonary hypoplasia	J:85424
	respiratory failure	J:85424
Nkx2-1tm1Shk/Nkx2-1+ involves: 129S4/SvJae	impaired coordination	J:74696
	increased circulating thyroid-stimulating hormone level	J:74696
Nkx2-1tm1Shk/Nkx2-1+ involves: 129S4/SvJae * C57BL/6 * CD-1	decreased surfactant secretion	J:117072
Nkx2-1tm1Shk/Nkx2-1tm1Shk B6.129S4-Nkx2-1tm1Shk	abnormal thyroid gland development	J:169693
	absent pituitary gland	J:169693
	absent thyroid gland	J:169693
	small thyroid gland	J:95017
Nkx2-1tm1Shk/Nkx2-1tm1Shk involves: 129S4/SvJae	abnormal adenohypophysis development	J:50517
	abnormal adrenal cortex morphology	J:30559
	abnormal bronchus epithelium morphology	J:30559
	abnormal bronchus morphology	J:30559
	abnormal diencephalon morphology	J:30559
	abnormal forebrain morphology	J:30559
	abnormal hypothalamus morphology	J:30559
	abnormal Leydig cell morphology	J:80472
	abnormal lung development	J:30559, J:54641, J:110629
	abnormal lung epithelium morphology	J:54641
	abnormal pleural cavity morphology	J:30559, J:54641
	abnormal pulmonary alveolar parenchyma morphology	J:30559
	abnormal pulmonary circulation	J:54641
	abnormal Rathke's pouch apoptosis	J:50517
	abnormal Rathke's pouch development	J:50517
	abnormal thoracic cavity morphology	J:54641
	abnormal thyroid gland development	J:110629
	abnormal trachea morphology	J:54641
	abnormal tracheal cartilage morphology	J:54641
	abnormal type II pneumocyte morphology	J:54641
	abnormal ventromedial hypothalamic nucleus morphology	J:30559
	absent pituitary gland	J:30559
	absent pituitary infundibular stalk	J:50517
	absent thyroid gland	J:30559
	absent type II pneumocytes	J:54641
	decreased fetal weight	J:30559
	decreased lung weight	J:54641
	decreased testes secretion	J:80472
	decreased testis weight	J:80472
	decreased tracheal cartilage ring number	J:54641
	decreased ventromedial hypothalamic nucleus size	J:30559
	normal endocrine/exocrine gland phenotype	J:30559
	impaired branching involved in bronchus morphogenesis	J:30559, J:54641
	neonatal lethality, complete penetrance	J:30559
	pulmonary hypoplasia	J:30559, J:110629
	normal reproductive system phenotype	J:80472
	tracheoesophageal fistula	J:54641
Nkx2-1tm1Shk/Nkx2-1tm1Shk involves: 129S4/SvJae * Black Swiss	abnormal foregut morphology	J:122531
Nkx2-1tm2.1(flpo)Zjh/Nkx2-1tm2.1(flpo)Zjh involves: 129S4/SvJae * BALB/cJ * C57BL/6	no abnormal phenotype detected	J:101977
Nkx2-1tm2Rdl/Nkx2-1tm2Rdl B6.129-Nkx2-1tm2Rdl	abnormal lung morphology	J:169693
	abnormal pituitary gland development	J:169693
	abnormal Rathke's pouch development	J:169693
	abnormal thyroid gland development	J:169693
	absent infundibular recess of third ventricle	J:169693
	absent pituitary gland	J:169693
	absent thyroid gland	J:169693
	neonatal lethality, complete penetrance	J:169693
	respiratory failure	J:169693
Nkx2-1tm2Shk/Nkx2-1tm2Shk involves: 129S4/SvJae * 129X1/SvJ	abnormal thyroid follicle morphology	J:111027
	increased circulating thyroid-stimulating hormone level	J:111027
Nkx2-1tm2Shk/Nkx2-1tm2Shk Tg(Syn1-cre)671Jxm/0 involves: 129X1/SvJ * C57BL/6 * CBA	abnormal ovulation	J:116686
	normal behavior/neurological phenotype	J:116686
	decreased exploration in new environment	J:116686
	delayed estrous cycle	J:116686
	delayed sexual maturation	J:116686
	early reproductive senescence	J:116686
	enhanced coordination	J:116686
	increased anxiety-related response	J:116686
	increased locomotor activity	J:116686
	normal nervous system phenotype	J:116686
	prolonged estrous cycle	J:116686
	reduced female fertility	J:116686
Nkx2-1tm2Shk/Nkx2-1tm2Shk Tg(TPO-cre)1Shk/0 involves: 129X1/SvJ * FVB/NCr	abnormal thyroid follicle morphology	J:111027
	increased adenoma incidence	J:111027
	increased circulating thyroid-stimulating hormone level	J:111027
	small thyroid gland	J:111027
Nkx2-1tm3Rdl/Nkx2-1tm3Rdl B6.129-Nkx2-1tm3Rdl	abnormal lung morphology	J:169693
	abnormal thyroid gland development	J:169693
	absent thyroid gland	J:169693
	neonatal lethality, complete penetrance	J:169693
	respiratory failure	J:169693