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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Myd88
myeloid differentiation primary response gene 88
MGI:108005
26 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Arih2tm1Mak/Arih2tm1Mak
Myd88tm1Aki/Myd88tm1Aki
involves: 129P2/OlaHsd * C57BL/6 		abnormal survival J:191066
Clec7atm1Yiw/Clec7atm1Yiw
Myd88tm1Aki/Myd88tm1Aki
involves: 129P2/OlaHsd * BALB/cA * C57BL/6J 		abnormal cytokine secretion J:116670
abnormal dendritic cell physiology J:116670
Faddtm1Mpa/Faddtm1Mpa
Myd88tm1Aki/Myd88tm1Aki
Tg(Vil1-cre)997Gum/0
B6.Cg-Faddtm1Mpa Myd88tm1Aki Tg(Vil1-cre)997Gum 		cecum inflammation J:175865
decreased Paneth cell number J:175865
normal digestive/alimentary phenotype J:175865
Ifna6tm1Aki/Ifna6+
Myd88tm1Aki/Myd88tm1Aki
involves: 129P2/OlaHsd 		abnormal plasmacytoid dendritic cell morphology J:124340
decreased interferon-alpha secretion J:124340
Ifnar1tm1Agt/Ifnar1tm1Agt
Myd88tm1Aki/Myd88+
B6.129-Myd88tm1Aki Ifnar1tm1Agt 		increased susceptibility to parasitic infection J:140485
Ifnar1tm1Agt/Ifnar1tm1Agt
Myd88tm1Aki/Myd88tm1Aki
B6.129-Myd88tm1Aki Ifnar1tm1Agt 		increased susceptibility to parasitic infection J:140485
increased susceptibility to parasitic infection induced morbidity/mortality J:140485
Ifnar1tm1Agt/Ifnar1tm1Agt
Myd88tm1Aki/Myd88tm1Aki
involves: 129P2/OlaHsd * 129S2/SvPas 		abnormal leukocyte migration J:171379
Igh-Jtm1(Ighel)Cys/Igh-Jtm1(Ighel)Cys
Myd88tm1Aki/Myd88tm1Aki
Igkj1tm1(IgkHyHEL10)Mnz/0
involves: 129P2/OlaHsd 		increased IgM level J:115059
Lyntm1.1Calo/Lyntm1.1Calo
Myd88tm1Defr/Myd88tm1Defr
Tg(Itgax-cre)1-1Reiz/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		normal immune system phenotype J:200745
normal renal/urinary system phenotype J:200745
Myd88poc/Myd88poc
Ptpn6m1Btlr/Ptpn6m1Btlr
C57BL/6J-Ptpn6m1Btlr Myd88poc 		normal immune system phenotype J:142845
Myd88tm1Aki/Myd88tm1Aki
Otulintm1c(EUCOMM)Hmgu/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA/2 		normal integument phenotype J:312394
Myd88tm1Aki/Myd88tm1Aki
Sh3bp2tm1.1Ics/Sh3bp2tm1.1Ics
involves: 129P2/OlaHsd * C57BL/6 		normal immune system phenotype J:221901
Myd88tm1Aki/Myd88tm1Aki
Tanktm1Aki/Tanktm1Aki
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 		increased anti-double stranded DNA antibody level J:151757
Myd88tm1Aki/Myd88tm1Aki
Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0
involves: 129P2/OlaHsd * C57BL/6 		decreased mature B cell number J:115059
increased B-1 B cell number J:115059
Myd88tm1Aki/Myd88tm1Aki
Tg(Vil-Myd88)#Lvh/0
involves: 129P2/OlaHsd 		normal digestive/alimentary phenotype J:177506
Myd88tm1Aki/Myd88tm1Aki
Ticam1tm1Aki/Ticam1+
B6.129P2-Myd88tm1Aki Ticam1tm1Aki 		decreased macrophage cytokine production J:140485
decreased macrophage nitric oxide production J:140485
increased susceptibility to parasitic infection J:140485
increased susceptibility to parasitic infection induced morbidity/mortality J:140485
Myd88tm1Aki/Myd88tm1Aki
Ticam1tm1Aki/Ticam1tm1Aki
B6.129P2-Myd88tm1Aki Ticam1tm1Aki 		decreased macrophage cytokine production J:140485
decreased macrophage nitric oxide production J:140485
increased susceptibility to parasitic infection J:140485
increased susceptibility to parasitic infection induced morbidity/mortality J:140485
Myd88tm1Aki/Myd88tm1Aki
Ticam1tm1Aki/Ticam1tm1Aki
involves: 129P2/OlaHsd 		abnormal dendritic cell physiology J:174941
abnormal macrophage physiology J:174941
Myd88tm1Aki/Myd88tm1Aki
Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl
Tg(Vil1-cre)997Gum/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		increased enterocyte apoptosis J:163410
increased susceptibility to induced colitis J:163410
Myd88tm1Aki/Myd88tm1Aki
Tnip1tm1.1Pcoh/Tnip1tm1.1Pcoh
involves: 129P2/OlaHsd * C57BL/6 		normal immune system phenotype J:176826
Myd88tm1Aki/Myd88tm1Aki
Traddtm1.1Mpa/Traddtm1.1Mpa
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 		decreased circulating tumor necrosis factor level J:139030
Myd88tm1Aki/Myd88tm1Aki
Unc93b1tm1.1Kmiy/Unc93b1tm1.1Kmiy
involves: 129P2/OlaHsd * C57BL/6 		normal hematopoietic system phenotype J:174308
Myd88tm1Defr/Myd88tm1Defr
Tnip1tm1.2Ama/Tnip1tm1.2Ama
Tg(Itgax-cre)1-1Reiz/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA 		normal hematopoietic system phenotype J:205446
normal immune system phenotype J:205446
Ticam1Lps2/Ticam1Lps2
Myd88tm1Aki/Myd88tm1Aki
involves: 129P2/OlaHsd * C57BL/6 		abnormal macrophage physiology J:84896
decreased tumor necrosis factor secretion J:84896
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/09/2024
MGI 6.23 		The Jackson Laboratory