59 phenotypes from 7 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Myl2tm1(cre)Krc/Myl2+ Slc8a1tm1Kdp/Slc8a1tm1Kdp involves: 129S4/SvJae	abnormal myocardial fiber physiology	J:101484
	decreased cardiac muscle contractility	J:101484
	enlarged heart	J:101484
	pregnancy-related premature death	J:101484
	premature death	J:101484
Slc8a1m51207Hubr/Slc8a1m51207Hubr involves: C57BL/6 * FVB/N	abnormal cardiovascular system physiology	J:167034
	abnormal heart tube morphology	J:167034
	abnormal pharyngeal arch morphology	J:167034
	absent heartbeat	J:167034
	absent placenta hemotrichorial membrane	J:167034
	absent placental labyrinth	J:167034
	absent vitelline blood vessels	J:167034
	edema	J:167034, J:173681
	embryonic lethality during organogenesis, complete penetrance	J:167034
	enlarged first pharyngeal arch	J:167034
Slc8a1tm1Herc/Slc8a1+ involves: 129 * CD-1	abnormal exocrine pancreas physiology	J:186743
	abnormal glucose homeostasis	J:186743
	abnormal pancreas physiology	J:186743
	increased insulin secretion	J:186743
	increased pancreatic beta cell mass	J:186743
	increased pancreatic beta cell proliferation	J:186743
Slc8a1tm1Herc/Slc8a1tm1Herc involves: 129 * CD-1	embryonic lethality, complete penetrance	J:186743
Slc8a1tm1Hssh/Slc8a1tm1Hssh involves: 129S4/SvJae * C3H * C57BL/6	abnormal myocardium layer morphology	J:106177
	abnormal placenta vasculature	J:106177
	abnormal visceral yolk sac morphology	J:106177
	abnormal vitelline vascular remodeling	J:106177
	absent placental labyrinth	J:106177
	decreased heart rate	J:106177
	distended pericardium	J:106177
	embryonic growth arrest	J:106177
	embryonic lethality during organogenesis, complete penetrance	J:106177
Slc8a1tm1Hssh/Slc8a1tm1Hssh involves: 129S4/SvJae * C57BL/6J	abnormal endocardium morphology	J:74096
	abnormal heart atrium morphology	J:74096
	abnormal heart development	J:74096
	absent atrioventricular cushions	J:74096
	decreased heart rate	J:74096
	distended pericardium	J:74096
	embryo tissue necrosis	J:74096
	embryonic growth arrest	J:74096
	embryonic lethality during organogenesis, complete penetrance	J:74096
	thin ventricular wall	J:74096
	trabecula carnea hypoplasia	J:74096
Slc8a1tm1Sjc/Slc8a1tm1Sjc involves: 129X1/SvJ * C57BL/6	abnormal cardiovascular system physiology	J:69362
	abnormal fetal cardiomyocyte morphology	J:69362
	abnormal heart morphology	J:69362
	abnormal visceral yolk sac morphology	J:69362
	abnormal vitelline vasculature morphology	J:69362
	absent atrioventricular cushions	J:69362
	absent heartbeat	J:69362
	absent vitelline blood vessels	J:69362
	decreased embryo size	J:69362
	embryonic growth retardation	J:69362
	embryonic lethality during organogenesis, complete penetrance	J:69362
	increased embryonic tissue cell apoptosis	J:69362
	poor circulation	J:69362
Slc8a1tm1Yin/Slc8a1+ involves: 129X1/SvJ * C57BL/6J	abnormal cardiac muscle relaxation	J:75050
	abnormal cardiovascular system physiology	J:65985
	cardiac interstitial fibrosis	J:75050
	heart left ventricle hypertrophy	J:75050
	impaired smooth muscle contractility	J:65985
	increased left ventricle diastolic pressure	J:75050
	increased left ventricle systolic pressure	J:75050
	increased ventricle muscle contractility	J:75050
Slc8a1tm1Yin/Slc8a1tm1Yin involves: 129X1/SvJ * C57BL/6J	abnormal cardiovascular system physiology	J:65985
	abnormal fetal cardiomyocyte morphology	J:65985, J:102564
	abnormal mitochondrial crista morphology	J:102564
	abnormal mitochondrial matrix morphology	J:102564
	abnormal mitochondrial shape	J:102564
	abnormal vitelline vascular remodeling	J:65985
	abnormal vitelline vasculature morphology	J:65985
	absent heartbeat	J:65985
	absent vitelline blood vessels	J:65985
	absent Z line	J:102564
	decreased embryo size	J:65985
	decreased myocardial fiber number	J:65985
	dilated mitochondrion	J:102564
	embryonic lethality during organogenesis, complete penetrance	J:65985
	enlarged pericardium	J:65985
	increased cardiomyocyte apoptosis	J:65985
	irregular heartbeat	J:65985
	poor circulation	J:65985
	thin ventricular wall	J:65985
Slc8a1tm2Kdp/Slc8a1tm2Kdp involves: 129S4/SvJae * Black Swiss	abnormal cardiovascular system physiology	J:102710, J:103484
	abnormal fetal cardiomyocyte morphology	J:102710
	embryonic lethality during organogenesis, complete penetrance	J:103484