Lrig1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lrig1
leucine-rich repeats and immunoglobulin-like domains 1
MGI:107935

23 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apc^tm2.1Cip/Apc⁺ Lrig1^{tm1.1(cre/ERT2)Rjc}/Lrig1⁺ involves: 129 * 129P2/OlaHsd * C57BL/6	increased intestinal adenoma incidence	J:186084
Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ Lrig1^{tm1.1(cre/ERT2)Rjc}/Lrig1^{tm1.1(cre/ERT2)Rjc} involves: 129 * 129P2/OlaHsd * C57BL/6	abnormal crypts of Lieberkuhn morphology	J:186084
	increased intestinal adenoma incidence	J:186084
Lrig1^{Gt(GST4169C6)Lex}/Lrig1⁺ Lrig3^tm1.1Good/Lrig3^tm1.1Good B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good	abnormal lateral semicircular canal morphology	J:202451
Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex} Lrig2^{Gt(RST656)Byg}/Lrig2⁺ B6N.129-Lrig2^{Gt(RST656)Byg} Lrig1^{Gt(GST4169C6)Lex}	abnormal sensory neuron innervation pattern	J:202451
	increased or absent distortion product otoacoustic emission threshold	J:202451
	increased or absent threshold for auditory brainstem response	J:202451
Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex} Lrig2^{Gt(RST656)Byg}/Lrig2^{Gt(RST656)Byg} B6N.129-Lrig2^{Gt(RST656)Byg} Lrig1^{Gt(GST4169C6)Lex}	abnormal auditory brainstem response waveform shape	J:202451
	abnormal sensory neuron innervation pattern	J:202451
	circling	J:202451
	decreased body size	J:202451
	normal hearing/vestibular/ear phenotype	J:202451
	increased or absent distortion product otoacoustic emission threshold	J:202451
	increased or absent threshold for auditory brainstem response	J:202451
	premature death	J:202451
Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good/Lrig3^tm1.1Good B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good	abnormal inner ear development	J:202451
	abnormal lateral semicircular canal morphology	J:202451
	abnormal otolith organ morphology	J:202451
	abnormal posterior semicircular canal morphology	J:202451
	abnormal skeleton morphology	J:202451
	decreased posterior semicircular canal size	J:202451
	microphthalmia	J:202451
	perinatal lethality, complete penetrance	J:202451
Scd1^tm2Ntam/Scd1^tm2Ntam Lrig1^{tm1.1(cre/ERT2)Rjc}/Lrig1⁺ B6.129(Cg)-Lrig1^{tm1.1(cre/ERT2)Rjc} Scd1^tm2Ntam	abnormal dermis papillary layer morphology	J:325761
	abnormal hair follicle matrix region morphology	J:325761
	abnormal hair shaft morphology	J:325761
	decreased hair follicle number	J:325761
	hair follicle degeneration	J:325761

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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