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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Rock1
Rho-associated coiled-coil containing protein kinase 1
MGI:107927
14 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Gt(ROSA)26Sortm1.1(Ubc-ROCK1*)Dnsh/Gt(ROSA)26Sor+
Tg(NPHS2-icre/ERT2)1Dnsh/0
involves: C57BL/6
abnormal podocyte foot process morphology J:182287
albuminuria J:182287
expanded mesangial matrix J:182287
podocyte foot process effacement J:182287
Leprdb/Leprdb
Rock1tm1Leiw/Rock1tm1Leiw
involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N
abnormal mitochondrial physiology J:182287
albuminuria J:182287
enlarged kidney J:182287
expanded mesangial matrix J:182287
hyperglycemia J:182287
increased body size J:182287
increased body weight J:182287
increased kidney weight J:182287
increased renal glomerulus apoptosis J:182287
increased renal glomerulus basement membrane thickness J:182287
oxidative stress J:182287
normal renal/urinary system phenotype J:182287

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory