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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Rock1
Rho-associated coiled-coil containing protein kinase 1
MGI:107927
38 phenotypes from 7 alleles in 7 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Rock1tm1.1Itl/Rock1tm1.1Itl
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
normal growth/size/body region phenotype J:204885
Rock1tm1.1Itl/Rock1tm1.1Itl
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
increased body weight J:204885
increased food intake J:204885
increased total body fat amount J:204885
Rock1tm1.1Itl/Rock1tm1.1Itl
Not Specified
abnormal autophagy J:207251
Rock1tm1.1Itl/Rock1tm1.1Itl
Agrptm1(cre)Lowl/Agrp+
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
increased body weight J:204885
increased epididymal fat pad weight J:204885
increased mesenteric fat pad weight J:204885
increased renal fat pad weight J:204885
increased total body fat amount J:204885
obese J:204885
Rock1tm1.1Itl/Rock1tm1.1Itl
Tg(Npy-hrGFP)1Lowl/0
Tg(Pomc1-cre)16Lowl/0
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
abnormal nervous system electrophysiology J:204885
Rock1tm1.1Itl/Rock1tm1.1Itl
Tg(Pomc1-cre)16Lowl/0
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
hypoactivity J:204885
increased body weight J:204885
increased circulating insulin level J:204885
increased circulating leptin level J:204885
increased epididymal fat pad weight J:204885
increased food intake J:204885
increased mesenteric fat pad weight J:204885
increased renal fat pad weight J:204885
increased total body fat amount J:204885
insulin resistance J:204885
normal skeleton phenotype J:204885
Rock1tm1.2Itl/Rock1tm1.2Itl
Not Specified
abnormal autophagy J:207251
Rock1tm1b(NCOM)Mfgc/Rock1+
C57BL/6N-Rock1tm1b(NCOM)Mfgc/Tcp
edema J:211773
Rock1tm1b(NCOM)Mfgc/Rock1tm1b(NCOM)Mfgc
C57BL/6N-Rock1tm1b(NCOM)Mfgc/Tcp
edema J:211773
preweaning lethality, incomplete penetrance J:211773
Rock1tm1Leiw/Rock1+
FVB.129S7-Rock1tm1Leiw
embryonic lethality at implantation, incomplete penetrance J:111469
Rock1tm1Leiw/Rock1tm1Leiw
FVB.129S7-Rock1tm1Leiw
abnormal cardiovascular system physiology J:111469
embryonic lethality at implantation, incomplete penetrance J:111469
increased heart rate J:111469
Rock1tm1Lex/Rock1tm1Lex
involves: 129S5/SvEvBrd * C57BL/6J
lethality, incomplete penetrance J:186058
ocular hypotension J:186058
premature death J:186058
normal vision/eye phenotype J:186058
Rock1tm1Liao/Rock1+
C57BL/6-Rock1tm1Liao
abnormal leukocyte adhesion J:135152
abnormal leukocyte migration J:135152
abnormal respiratory system physiology J:112242
abnormal vascular endothelial cell physiology J:135152
abnormal vascular smooth muscle morphology J:135152
abnormal vascular wound healing J:135152
impaired macrophage chemotaxis J:135152
impaired neutrophil recruitment J:135152
Rock1tm1Sna/Rock1tm1Sna
B6N.129X1-Rock1tm1Sna
abnormal eyelid morphology J:98250
abnormal keratinocyte morphology J:98250
blepharitis J:98250
eyelids open at birth J:98250
omphalocele J:98250
postnatal lethality, incomplete penetrance J:98250

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory