Rock1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rock1
Rho-associated coiled-coil containing protein kinase 1
MGI:107927

38 phenotypes from 7 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rock1^tm1.1Itl/Rock1^tm1.1Itl involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	normal growth/size/body region phenotype	J:204885
Rock1^tm1.1Itl/Rock1^tm1.1Itl involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	increased body weight	J:204885
	increased food intake	J:204885
	increased total body fat amount	J:204885
Rock1^tm1.1Itl/Rock1^tm1.1Itl Not Specified	abnormal autophagy	J:207251
Rock1^tm1.1Itl/Rock1^tm1.1Itl Agrp^tm1(cre)Lowl/Agrp⁺ involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	increased body weight	J:204885
	increased epididymal fat pad weight	J:204885
	increased mesenteric fat pad weight	J:204885
	increased renal fat pad weight	J:204885
	increased total body fat amount	J:204885
	obese	J:204885
Rock1^tm1.1Itl/Rock1^tm1.1Itl Tg(Npy-hrGFP)1Lowl/0 Tg(Pomc1-cre)16Lowl/0 involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	abnormal nervous system electrophysiology	J:204885
Rock1^tm1.1Itl/Rock1^tm1.1Itl Tg(Pomc1-cre)16Lowl/0 involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	decreased locomotor activity	J:204885
	increased body weight	J:204885
	increased circulating insulin level	J:204885
	increased circulating leptin level	J:204885
	increased epididymal fat pad weight	J:204885
	increased food intake	J:204885
	increased mesenteric fat pad weight	J:204885
	increased renal fat pad weight	J:204885
	increased total body fat amount	J:204885
	insulin resistance	J:204885
	normal skeleton phenotype	J:204885
Rock1^tm1.2Itl/Rock1^tm1.2Itl Not Specified	abnormal autophagy	J:207251
Rock1^{tm1b(NCOM)Mfgc}/Rock1^{tm1b(NCOM)Mfgc} C57BL/6N-Rock1^{tm1b(NCOM)Mfgc}/Tcp	edema	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Rock1^tm1Leiw/Rock1⁺ FVB.129S7-Rock1^tm1Leiw	embryonic lethality at implantation, incomplete penetrance	J:111469
Rock1^tm1Leiw/Rock1^tm1Leiw FVB.129S7-Rock1^tm1Leiw	abnormal cardiovascular system physiology	J:111469
	embryonic lethality at implantation, incomplete penetrance	J:111469
	increased heart rate	J:111469
Rock1^tm1Lex/Rock1^tm1Lex involves: 129S5/SvEvBrd * C57BL/6J	lethality, incomplete penetrance	J:186058
	ocular hypotension	J:186058
	premature death	J:186058
	normal vision/eye phenotype	J:186058
Rock1^tm1Liao/Rock1⁺ C57BL/6-Rock1^tm1Liao	abnormal leukocyte adhesion	J:135152
	abnormal leukocyte migration	J:135152
	abnormal respiratory system physiology	J:112242
	abnormal vascular endothelial cell physiology	J:135152
	abnormal vascular smooth muscle morphology	J:135152
	abnormal vascular wound healing	J:135152
	impaired macrophage chemotaxis	J:135152
	impaired neutrophil recruitment	J:135152
Rock1^tm1Sna/Rock1^tm1Sna B6N.129X1-Rock1^tm1Sna	abnormal eyelid morphology	J:98250
	abnormal keratinocyte morphology	J:98250
	blepharitis	J:98250
	eyelids open at birth	J:98250
	omphalocele	J:98250
	postnatal lethality, incomplete penetrance	J:98250

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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