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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ctsk
cathepsin K
MGI:107823
46 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cthrc1tm1.1Suna/Cthrc1tm1.1Suna
Ctsktm1(cre)Ska/Ctsk+
involves: 129S6/SvEvTac * C57BL/6NCrlj * C57BL/6NTac * CBA/JNCrlj 		abnormal osteoid morphology J:201631
decreased bone mass J:201631
decreased bone ossification J:201631
decreased bone trabecula number J:201631
decreased trabecular bone thickness J:201631
increased bone trabecular spacing J:201631
osteoporosis J:201631
normal skeleton phenotype J:201631
Ctnnb1tm1Mmt/Ctnnb1+
Ctsktm1(cre)Ska/Ctsk+
involves: 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj 		abnormal osteoclast differentiation J:178340
decreased bone marrow cell number J:178340
decreased bone resorption J:178340
increased bone volume J:178340
normal skeleton phenotype J:178340
Ctnnb1tm2Kem/Ctnnb1+
Ctsktm1(cre)Ska/Ctsk+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj 		decreased trabecular bone volume J:178340
increased bone resorption J:178340
increased osteoclast cell number J:178340
osteoporosis J:178340
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Ctsktm1(cre)Ska/Ctsk+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj 		decreased trabecular bone volume J:178340
increased bone resorption J:178340
increased osteoclast cell number J:178340
osteoporosis J:178340
Ctsbtm1Jde/Ctsbtm1Jde
Ctsktm1Psa/Ctsktm1Psa
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J 		abnormal thyroid follicle morphology J:83877
abnormal thyroid follicular cell morphology J:83877
abnormal thyroid hormone level J:83877
Ctsktm1(cre)Ska/Ctsk+
Esr1tm1Mma/Esr1tm1Mma
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal osteoclast physiology J:127179
decreased bone mineral density of femur J:127179
increased bone mineralization J:127179
increased bone ossification J:127179
increased bone resorption J:127179
increased osteoclast cell number J:127179
osteoporosis J:127179
Ctsktm1(cre)Ska/Ctsk+
Snx10tm1c(EUCOMM)Raba/Snx10tm1c(EUCOMM)Raba
involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj 		abnormal epiphyseal plate morphology J:224711
abnormal osteoclast physiology J:224711
decreased bone volume J:224711
normal digestive/alimentary phenotype J:224711
failure of tooth eruption J:224711
increased bone mineral density J:224711
osteopetrosis J:224711
postnatal growth retardation J:224711
Ctsktm1(cre)Ska/Ctsk+
Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj 		abnormal lysosome morphology J:236517
abnormal osteoclast morphology J:236517
abnormal osteoclast physiology J:236517
decreased bone mineralization J:236517
decreased bone ossification J:236517
decreased bone resorption J:236517
decreased bone trabecular spacing J:236517
decreased lysosomal enzyme secretion J:236517
decreased osteoblast cell number J:236517
increased bone trabecula number J:236517
increased trabecular bone mass J:236517
increased trabecular bone volume J:236517
Ctsktm1Psa/Ctsktm1Psa
Ctsltm1Cptr/Ctsltm1Cptr
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J 		abnormal thyroid follicle morphology J:83877
abnormal thyroid gland morphology J:83877
abnormal thyroid hormone level J:83877
decreased circulating thyroxine level J:83877
decreased thyroxine level J:83877
Slc4a2tm2Ges/Slc4a2tm2Ges
Ctsktm1(cre)Ska/Ctsk+
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal bone marrow cavity morphology J:193823
abnormal long bone metaphysis morphology J:193823
abnormal long bone morphology J:193823
abnormal osteoclast morphology J:193823
abnormal osteoclast physiology J:193823
abnormal trabecular bone morphology J:193823
increased bone trabecula number J:193823
increased trabecular bone thickness J:193823
increased trabecular bone volume J:193823
osteopetrosis J:193823
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/09/2024
MGI 6.23 		The Jackson Laboratory