Gfer Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gfer
growth factor, augmenter of liver regeneration
MGI:107757

38 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gfer^tm1(KOMP)Mbp/Gfer⁺ involves: C57BL/6J * C57BL/6N	abnormal hepatocyte mitochondrial morphology	J:224792
	abnormal hepatocyte physiology	J:224792
	abnormal lipid oxidation	J:224792
	abnormal mitochondrial crista morphology	J:224792
	abnormal mitochondrial physiology	J:224792
	decreased hepatocyte mitochondrial DNA content	J:224792
	decreased hepatocyte proliferation	J:224792
	decreased mitochondrial number	J:224792
	dilated mitochondrion	J:224792
	impaired liver regeneration	J:224792
	increased susceptibility to injury	J:224792
	oxidative stress	J:224792
Gfer^tm1(KOMP)Mbp/Gfer^tm1(KOMP)Mbp involves: C57BL/6J * C57BL/6N	embryonic lethality, complete penetrance	J:224792
Gfer^tm1.1Crg/Gfer^tm1.1Crg involves: 129 * C57BL/6	abnormal hepatocyte morphology	J:227242
	abnormal mitochondrial chromosome morphology	J:227242
	oxidative stress	J:227242
Gfer^tm1.1Crg/Gfer^tm1.1Crg Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129 * C57BL/6 * DBA	abnormal cellular respiration	J:227242
	abnormal endoplasmic reticulum morphology	J:227242
	abnormal hepatocyte mitochondrial morphology	J:227242
	abnormal liver morphology	J:227242
	abnormal liver physiology	J:227242
	abnormal mitochondrial crista morphology	J:227242
	abnormal mitochondrial shape	J:227242
	abnormal oval cell physiology	J:227242
	decreased body weight	J:227242
	decreased liver cholesterol level	J:227242
	decreased mitochondrial number	J:227242
	dilated mitochondrion	J:227242
	focal hepatic necrosis	J:227242
	hepatic necrosis	J:227242
	hepatic steatosis	J:227242
	increased circulating alanine transaminase level	J:227242
	increased hepatocellular carcinoma incidence	J:227242
	increased hepatocyte apoptosis	J:227242
	increased hepatocyte proliferation	J:227242
	increased liver cholesterol level	J:227242
	increased liver triglyceride level	J:227242
	increased liver weight	J:227242
	liver fibrosis	J:227242
	liver inflammation	J:227242
	macrovesicular hepatic steatosis	J:227242
	microvesicular hepatic steatosis	J:227242
	pale liver	J:227242
Gfer^tm1.2Crg/Gfer^tm1.2Crg involves: 129 * C57BL/6 * FVB/N	embryonic lethality, complete penetrance	J:227242

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23