Casp4 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Casp4
caspase 4, apoptosis-related cysteine peptidase
MGI:107700

14 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Casp4^tm1.1Vmd/Casp4^tm1.1Vmd involves: C57BL/6	decreased circulating interleukin-1 alpha level	J:193522
	decreased circulating interleukin-1 beta level	J:193522
	decreased circulating interleukin-18 level	J:193522
	decreased interleukin-1 alpha secretion	J:193522
	decreased interleukin-1 beta secretion	J:193522
	decreased macrophage apoptosis	J:193522
	decreased susceptibility to endotoxin shock	J:193522
	decreased susceptibility to xenobiotic induced morbidity/mortality	J:193522
Casp4^{tm1b(KOMP)Wtsi}/Casp4^{tm1b(KOMP)Wtsi} C57BL/6N-Casp4^{tm1b(KOMP)Wtsi}/MbpMmucd	decreased pulmonary ventilation	J:211773
Casp4^{tm1b(KOMP)Wtsi}/Casp4^{tm1b(KOMP)Wtsi} C57BL/6N-Casp4^{tm1b(KOMP)Wtsi}/Ucd	increased circulating bilirubin level	J:211773
	increased circulating calcium level	J:211773
	increased circulating glucose level	J:211773
	increased circulating insulin level	J:211773
Casp4^tm1Yuan/Casp4^tm1Yuan B6.129S4(D2)-Casp4^tm1Yuan/J	decreased interleukin-1 beta secretion	J:270123
Casp4^tm1Yuan/Casp4^tm1Yuan B6.129S4(D2)-Casp4^tm1Yuan/J	decreased interleukin-18 secretion	J:270123
Casp4^tm1Yuan/Casp4^tm1Yuan involves: 129S4/SvJae * C57BL/6J * DBA/2	decreased circulating interleukin-1 alpha level	J:46167
	decreased circulating interleukin-1 beta level	J:46167
	decreased susceptibility to endotoxin shock	J:46167

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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