73 phenotypes from 7 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gdnftm1(cre/ERT2)Cos/Gdnftm1(cre/ERT2)Cos involves: 129S6/SvEvTac * C57BL/6J	normal renal/urinary system phenotype	J:206853
Gdnftm1.1Neas/Gdnftm1.1Neas Egr3tm1(cre)Mod/Egr3tm1(cre)Mod involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL	abnormal cholinergic neuron morphology	J:160727
	decreased motor neuron number	J:160727
	normal muscle phenotype	J:160727
Gdnftm1.1Neas/Gdnftm1.1Neas Myf5tm3(cre)Sor/Myf5+ involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * SJL	abnormal cholinergic neuron morphology	J:160727
	decreased motor neuron number	J:160727
Gdnftm1Bbd/Gdnf+ involves: 129S1/Sv * C57BL/6	absent kidney	J:33809
	absent ureteric bud	J:33809
	single kidney	J:33809
	small kidney	J:206853
Gdnftm1Bbd/Gdnftm1.1Neas Egr3tm1(cre)Mod/Egr3+ involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL	abnormal cholinergic neuron morphology	J:160727
	decreased motor neuron number	J:160727
Gdnftm1Bbd/Gdnftm1Bbd involves: 129S1/Sv * C57BL/6	abnormal superior cervical ganglion morphology	J:33809
	abnormal ureteric bud invasion	J:33809
	absent enteric neurons	J:33809
	absent kidney	J:33809
	absent ureteric bud	J:33809
	decreased motor neuron number	J:33809
	distended duodenum	J:33809
	neonatal lethality, complete penetrance	J:33809
	pyloric stenosis	J:33809
Gdnftm1Bbd/Gdnftm1Jlob Tg(CAG-cre/Esr1*)5Amc/0 involves: 129S1/Sv * C57BL/6 * CBA	abnormal brain morphology	J:139371
	abnormal carotid body morphology	J:139371
	abnormal dorsal striatum morphology	J:139371
	abnormal locus ceruleus morphology	J:139371
	abnormal substantia nigra morphology	J:139371
	abnormal tegmentum morphology	J:139371
	abnormal ventral striatum morphology	J:139371
	decreased locomotor activity	J:139371
Gdnftm1Lmgd/Gdnf+ B6.129-Gdnftm1Lmgd	abnormal glomerular capillary endothelium morphology	J:168650
	abnormal podocyte morphology	J:168650
	abnormal renal corpuscle morphology	J:103081
	abnormal renal tubule morphology	J:103081
	normal cardiovascular system phenotype	J:168650
	decreased glomerular capillary number	J:168650
	decreased kidney weight	J:168650
	decreased nephron number	J:103081, J:168650
	decreased podocyte number	J:168650
	decreased renal glomerulus number	J:103081
	fused podocyte foot processes	J:168650
	increased compensatory renal growth	J:168650
	increased kidney cell proliferation	J:168650
	increased mean systemic arterial blood pressure	J:103081
	increased mesangial cell number	J:168650
	increased renal glomerulus basement membrane thickness	J:168650
	kidney cortex cyst	J:103081
	renal glomerulus hypertrophy	J:103081, J:168650
	renal interstitial fibrosis	J:168650
	normal renal/urinary system phenotype	J:103081, J:168650
	single kidney	J:168650
	tubulointerstitial nephritis	J:103081
Gdnftm1Lmgd/Gdnf+ either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)	abnormal enteric ganglia morphology	J:73922
	abnormal myenteric nerve plexus morphology	J:73922
	abnormal submucous nerve plexus morphology	J:73922
	chronic constipation	J:73922
	distended stomach	J:73922
	intestinal hypoperistalsis	J:73922
	megacolon	J:73922
	preweaning lethality, incomplete penetrance	J:73922
	single kidney	J:73922
Gdnftm1Lmgd/Gdnf+ either: (involves: 129S4/SvJae) or (involves: 129S1/Sv * 129X1/SvJ)	abnormal kidney development	J:33810
	abnormal kidney morphology	J:33810
	abnormal ureteric bud morphology	J:33810
	impaired branching involved in ureteric bud morphogenesis	J:33810
	single kidney	J:33810
	small kidney	J:33810
Gdnftm1Lmgd/Gdnf+ involves: 129/Sv * C57BL/6	abnormal renal corpuscle morphology	J:103800
	decreased nephron number	J:103800
	decreased renal glomerulus number	J:103800
	normal growth/size/body region phenotype	J:103800
	impaired branching involved in ureteric bud morphogenesis	J:103800
	increased kidney weight	J:103800
	single kidney	J:103800
	small kidney	J:103800
Gdnftm1Lmgd/Gdnftm1Lmgd either: (involves: 129S4/SvJae) or (involves: 129S1/Sv * 129X1/SvJ)	abnormal enteric cholinergic neuron morphology	J:33810
	abnormal kidney development	J:33810
	absent enteric neurons	J:33810
	absent kidney	J:33810
	absent ureteric bud	J:33810
	impaired branching involved in ureteric bud morphogenesis	J:33810
	intestinal hypoperistalsis	J:33810
	neonatal lethality, complete penetrance	J:33810
Gdnftm1Rosl/Gdnf+ involves: 129S2/SvPas	absent kidney	J:122519
	renal hypoplasia	J:33808
	single kidney	J:33808
Gdnftm1Rosl/Gdnf+ involves: 129S2/SvPas * C57BL/6	abnormal enteric ganglia morphology	J:82456
	abnormal enteric nervous system morphology	J:82456
	abnormal enteric neuron morphology	J:82456
	abnormal neurotransmitter secretion	J:82456
	intestinal hypoperistalsis	J:82456
Gdnftm1Rosl/Gdnftm1Rosl involves: 129S2/SvPas	abnormal cranial ganglia morphology	J:33808
	abnormal innervation pattern to muscle	J:110955
	abnormal intestine morphology	J:33808
	abnormal metanephric mesenchyme morphology	J:33808
	abnormal motor neuron innervation pattern	J:132854
	abnormal muscle spindle morphology	J:132854
	abnormal ovary topology	J:33808
	abnormal spleen red pulp morphology	J:33808
	absent enteric neurons	J:33808
	absent kidney	J:33808
	absent ureter	J:33808
	absent ureteric bud	J:33808
	decreased motor neuron number	J:132854
	neonatal lethality, complete penetrance	J:33808
	small dorsal root ganglion	J:33808
Gdnftm1Rosl/Gdnftm1Rosl involves: 129S2/SvPas * CD-1	abnormal innervation pattern to muscle	J:78718
	abnormal spinal cord lateral motor column morphology	J:78718
	abnormal spinal nerve morphology	J:78718
Gdnftm2Bbd/Gdnf+ involves: 129S1/Sv * C57BL/6	absent kidney	J:33809
	absent ureteric bud	J:33809
	single kidney	J:33809
Gdnftm2Bbd/Gdnftm2Bbd involves: 129S1/Sv * C57BL/6	abnormal superior cervical ganglion morphology	J:33809
	abnormal ureteric bud invasion	J:33809
	absent enteric neurons	J:33809
	absent kidney	J:33809
	absent ureteric bud	J:33809
	decreased motor neuron number	J:33809
	distended duodenum	J:33809
	neonatal lethality, complete penetrance	J:33809
	pyloric stenosis	J:33809