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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tbr1
T-box brain transcription factor 1
MGI:107404
46 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tbr1tm1.1(KOMP)Mbp/Tbr1+
C57BL/6N-Tbr1tm1.1(KOMP)Mbp/Ucd 		anophthalmia J:211773
decreased blood urea nitrogen level J:211773
decreased circulating creatinine level J:211773
decreased circulating glucose level J:211773
hemorrhage J:211773
microcephaly J:211773
microphthalmia J:211773
polydactyly J:211773
spina bifida J:211773
syndactyly J:211773
Tbr1tm1.1(KOMP)Mbp/Tbr1tm1.1(KOMP)Mbp
C57BL/6N-Tbr1tm1.1(KOMP)Mbp/Ucd 		anophthalmia J:211773
hemorrhage J:211773
microcephaly J:211773
microphthalmia J:211773
polydactyly J:211773
preweaning lethality, incomplete penetrance J:211773
spina bifida J:211773
syndactyly J:211773
Tbr1tm1.1Csbd/Tbr1+
involves: C57BL/6J 		abnormal brain interneuron morphology J:281878
abnormal habituation to a new environment J:281878
abnormal social/conspecific interaction behavior J:281878
decreased thigmotaxis J:281878
increased anxiety-related response J:281878
increased excitatory postsynaptic current frequency J:281878
increased grooming behavior J:281878
increased locomotor activity J:281878
increased miniature inhibitory postsynaptic current frequency J:281878
increased vertical activity J:281878
Tbr1tm1.1Csbd/Tbr1tm1.1Csbd
involves: C57BL/6J 		preweaning lethality, complete penetrance J:281878
Tbr1tm1Jlr/Tbr1+
B6.129X1-Tbr1tm1Jlr 		abnormal amygdala morphology J:208050
abnormal anterior commissure morphology J:208050
abnormal conditioned taste aversion behavior J:208050
abnormal cued conditioning behavior J:208050
abnormal innervation J:208050
abnormal neuron physiology J:208050
abnormal social investigation J:208050
cognitive inflexibility J:208050
decreased vocalization J:208050
impaired social transmission of food preference J:208050
Tbr1tm1Jlr/Tbr1tm1Jlr
involves: 129X1/SvJ 		abnormal forebrain morphology J:51888
abnormal mitral cell morphology J:51888
abnormal olfactory bulb development J:51888
abnormal olfactory bulb external plexiform layer morphology J:51888
abnormal olfactory bulb glomerular layer morphology J:51888
abnormal olfactory bulb interneuron morphology J:51888
abnormal olfactory bulb mitral cell layer morphology J:51888
abnormal olfactory bulb tufted cell morphology J:51888
abnormal olfactory cortex morphology J:51888
abnormal olfactory tract morphology J:51888
aphagia J:51888
decreased brain size J:51888
olfactory bulb hypoplasia J:51888
postnatal lethality, complete penetrance J:51888
Tbr1tm1Jlr/Tbr1tm1Jlr
Tg(Mbp-MAPT/EGFP)#Eja/0
involves: 129X1/SvJ 		abnormal innervation J:169221
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory