Dnm1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dnm1
dynamin 1
MGI:107384

36 phenotypes from 6 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dnm1^Ftfl/Dnm1⁺ C57BL/6J-Dnm1^Ftfl	abnormal kindling response	J:163311
	abnormal seizure response to electrical stimulation	J:163311
	tonic seizures	J:163311
Dnm1^Ftfl/Dnm1⁺ FVB.B6-Dnm1^Ftfl/Frk	seizures	J:235711
Dnm1^Ftfl/Dnm1^Ftfl C57BL/6J-Dnm1^Ftfl	abnormal auditory brainstem response waveform shape	J:163311
	abnormal gait	J:163311
	abnormal Purkinje cell dendrite morphology	J:163311
	ataxia	J:163311
	convulsive seizures	J:163311
	impaired limb coordination	J:163311
	increased or absent threshold for auditory brainstem response	J:163311
	postnatal lethality, complete penetrance	J:163311
	tonic-clonic seizures	J:163311
Dnm1^Ftfl/Dnm1^Ftfl Tg(Pvalb-EGFP)B20Zjh/0 involves: C57BL/6 * C57BL/6J * FVB	abnormal Purkinje cell dendrite morphology	J:163311
Dnm1^Ftfl/Dnm1^tm1.2Frk involves: 129 * C57BL/6J * FVB	abnormal brain wave pattern	J:235711
	premature death	J:235711
	seizures	J:235711
Dnm1^Ftfl/Dnm1^tm1Pdc involves: C57BL/6J	abnormal motor capabilities/coordination/movement	J:163311
	hunched posture	J:163311
	tremors	J:163311
Dnm1^Ftfl/Dnm1^tm2.2Frk involves: 129 * C57BL/6J * FVB	seizures	J:235711
Dnm1^{tm1.1(KOMP)Vlcg}/Dnm1⁺ C57BL/6N-Dnm1^{tm1.1(KOMP)Vlcg}/Ucd	anophthalmia	J:211773
	hemorrhage	J:211773
	microcephaly	J:211773
	microphthalmia	J:211773
	polydactyly	J:211773
	spina bifida	J:211773
	syndactyly	J:211773
Dnm1^{tm1.1(KOMP)Vlcg}/Dnm1^{tm1.1(KOMP)Vlcg} C57BL/6N-Dnm1^{tm1.1(KOMP)Vlcg}/Ucd	anophthalmia	J:211773
	hemorrhage	J:211773
	microcephaly	J:211773
	microphthalmia	J:211773
	polydactyly	J:211773
	preweaning lethality, complete penetrance	J:211773
	spina bifida	J:211773
	syndactyly	J:211773
Dnm1^tm1.2Frk/Dnm1^tm1.2Frk B6.129(Cg)-Dnm1^tm1.2Frk	normal nervous system phenotype	J:235711
Dnm1^tm1Pdc/Dnm1^tm1Pdc involves: 129X1/SvJ * C57BL/6	abnormal CNS synaptic transmission	J:121111
	abnormal inhibitory postsynaptic currents	J:121111
	abnormal miniature excitatory postsynaptic currents	J:121111
	abnormal motor capabilities/coordination/movement	J:121111
	abnormal neuron morphology	J:121111
	abnormal suckling behavior	J:121111
	abnormal synaptic vesicle morphology	J:121111
	abnormal synaptic vesicle number	J:121111
	abnormal synaptic vesicle recycling	J:121111
	postnatal lethality, complete penetrance	J:121111
Dnm1^tm2.1Pdc/Dnm1^tm2.1Pdc involves: 129S1/SvImJ * C57BL/6	no abnormal phenotype detected	J:161127
Dnm1^tm2.2Frk/Dnm1^tm2.2Frk B6.129(Cg)-Dnm1^tm2.2Frk	normal nervous system phenotype	J:235711

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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