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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mttp
microsomal triglyceride transfer protein
MGI:106926
27 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mttptm1Chan/Mttptm1Chan
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal circulating cholesterol level J:53390
abnormal triglyceride level J:53390
decreased circulating HDL cholesterol level J:53390
decreased circulating LDL cholesterol level J:53390
decreased circulating VLDL cholesterol level J:53390
decreased circulating VLDL triglyceride level J:53390
Mttptm1Sgy/Mttp+
involves: 129S4/SvJae 		abnormal circulating cholesterol level J:48934
abnormal circulating lipid level J:48934
abnormal lipid homeostasis J:48934
abnormal lipid level J:48934
abnormal visceral yolk sac endoderm morphology J:48934
decreased circulating cholesterol level J:48934
decreased circulating LDL cholesterol level J:48934
decreased circulating VLDL cholesterol level J:48934
hepatic steatosis J:48934
increased liver cholesterol level J:48934
increased liver triglyceride level J:48934
Mttptm1Sgy/Mttptm1Sgy
involves: 129S4/SvJae 		abnormal lipid homeostasis J:48934
abnormal visceral yolk sac blood island morphology J:48934
abnormal visceral yolk sac endoderm morphology J:48934
decreased erythrocyte cell number J:48934
embryo tissue necrosis J:48934
embryonic growth retardation J:48934
embryonic lethality during organogenesis, incomplete penetrance J:48934
exencephaly J:48934
hemorrhage J:48934
incomplete rostral neuropore closure J:48934
pale yolk sac J:48934
Mttptm2Sgy/Mttptm2Sgy
Tg(Mx1-cre)1Cgn/Tg(Mx1-cre)1Cgn
involves: 129S4/SvJae * C57BL/6 * CBA 		abnormal circulating protein level J:83459
abnormal liver physiology J:83459
decreased circulating cholesterol level J:83459
decreased circulating HDL cholesterol level J:83459
decreased circulating LDL cholesterol level J:83459
decreased circulating triglyceride level J:83459
decreased circulating VLDL cholesterol level J:83459
increased liver cholesterol level J:83459
increased liver triglyceride level J:83459
increased liver weight J:83459
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory