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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hif1a
hypoxia inducible factor 1, alpha subunit
MGI:106918
177 phenotypes from 9 alleles in 21 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ccl17tm2.1(cre)Ifo/Ccl17+
Hif1atm3Rsjo/Hif1atm3Rsjo
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cell physiology J:187773
abnormal dendritic cell number J:187773
abnormal interleukin-1 beta secretion J:187773
abnormal leukocyte migration J:187773
abnormal tumor necrosis factor secretion J:187773
normal immune system phenotype J:187773
Hif1atm1.1Stom/Hif1atm1.1Stom
Not Specified 		prenatal lethality, complete penetrance J:85763
Hif1atm1Jhu/Hif1atm1Jhu
involves: 129S4/SvJae * C57BL/6 		abnormal blood vessel morphology J:45554
abnormal cardiac outflow tract development J:45554
abnormal dorsal aorta morphology J:45554
abnormal head mesenchyme morphology J:45554
abnormal heart tube morphology J:45554
abnormal heart ventricle morphology J:45554
abnormal intersomitic vessel morphology J:45554
abnormal myocardium layer morphology J:45554
abnormal pericardial cavity morphology J:45554
abnormal pericardium morphology J:45554
abnormal vascular development J:45554
absent pharyngeal arch arteries J:45554
dilated dorsal aorta J:45554
disorganized myocardium J:45554
embryonic growth arrest J:45554
embryonic lethality during organogenesis, complete penetrance J:45554
incomplete somite formation J:45554
increased apoptosis J:45554
increased hindbrain size J:45554
open neural tube J:45554
pericardial effusion J:45554
pharyngeal arch artery hypoplasia J:45554
Hif1atm1Kats/Hif1atm1Kats
involves: 129 * C57BL/6 		abnormal cytokine level J:117857
abnormal interleukin secretion J:117857
increased interferon-gamma secretion J:117857
increased tumor necrosis factor secretion J:117857
Hif1atm1Mcs/Hif1atm1Mcs
involves: 129S6/SvEvTac 		no abnormal phenotype detected J:97164
Hif1atm1Pec/Hif1atm1Pec
involves: 129S6/SvEvTac 		embryonic growth arrest J:105812
Hif1atm1Pec/Hif1atm1Pec
involves: 129X1/SvJ * Swiss 		abnormal angiogenesis J:102537
abnormal dorsal aorta morphology J:102537
abnormal heart development J:102537
abnormal heart looping J:102537
abnormal heart ventricle morphology J:102537
abnormal metabolism J:102537
abnormal myocardial trabeculae morphology J:102537
abnormal neural crest cell migration J:102537
abnormal pharyngeal arch morphology J:102537
abnormal vascular regression J:102537
abnormal vitelline vascular remodeling J:102537
absent myocardial trabeculae J:102537
absent second pharyngeal arch J:102537
absent third pharyngeal arch J:102537
cardia bifida J:102537
embryonic growth retardation J:102537
embryonic lethality during organogenesis, incomplete penetrance J:102537
open neural tube J:102537
small second pharyngeal arch J:102537
Hif1atm1Rsjo/Hif1a+
involves: 129S1/Sv * 129X1/SvJ 		decreased neuron apoptosis J:98637
Hif1atm1Rsjo/Hif1atm1Rsjo
involves: 129S1/Sv * 129X1/SvJ 		abnormal dorsal aorta morphology J:48084
abnormal neural fold formation J:48084
abnormal somite development J:48084
decreased angiogenesis J:48084
decreased embryo size J:48084
disorganized yolk sac vascular plexus J:48084
hypoxia J:48084
increased embryonic tissue cell apoptosis J:48084
Hif1atm1Rsjo/Hif1atm3Rsjo
Tg(Col2a1-cre)1Rsjo/?
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal angiogenesis J:72709
abnormal cartilage development J:72709
abnormal long bone epiphyseal plate proliferative zone J:72709
abnormal long bone hypertrophic chondrocyte zone J:72709
abnormal long bone morphology J:72709
abnormal sternocostal joint morphology J:72709
abnormal sternum morphology J:72709
abnormal thoracic cage shape J:72709
abnormal tracheal cartilage morphology J:72709
abnormal tracheal ciliated epithelium morphology J:72709
decreased embryo size J:72709
decreased length of long bones J:72709
disorganized long bone epiphyseal plate J:72709
increased long bone epiphyseal plate size J:72709
neonatal lethality, complete penetrance J:72709
respiratory failure J:72709
short limbs J:72709
Hif1atm1Stom/Hif1atm1.1Stom
Tg(Nes-cre)1Kag/0
Not Specified 		abnormal cerebral cortex morphology J:85763
abnormal cerebral hemisphere morphology J:85763
abnormal cortical plate morphology J:85763
abnormal occipital lobe morphology J:85763
abnormal spatial learning J:85763
abnormal temporal lobe morphology J:85763
normal behavior/neurological phenotype J:85763
enlarged lateral ventricles J:85763
hydrocephaly J:85763
loss of cortex neurons J:85763
loss of hippocampal neurons J:85763
Hif1atm1Stom/Hif1atm1Stom
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: FVB/N 		abnormal cardiovascular system physiology J:120332
abnormal heart size J:120332
decreased angiogenesis J:120332
Hif1atm1Stom/Hif1atm1Stom
Tg(Vil1-cre)20Syr/0
B6.Cg-Hif1atm1Stom Tg(Vil1-cre)20Syr 		abnormal gut flora balance J:325395
decreased body fat mass J:325395
decreased circulating insulin level J:325395
decreased susceptibility to diet-induced obesity J:325395
decreased susceptibility to induced hypothermia J:325395
improved glucose tolerance J:325395
increased bile salt level J:325395
increased energy expenditure J:325395
increased insulin sensitivity J:325395
increased oxygen consumption J:325395
increased respiratory quotient J:325395
Hif1atm2Rsjo/Hif1atm2Rsjo
involves: 129S1/Sv * 129X1/SvJ 		abnormal dorsal aorta morphology J:48084
abnormal neural fold formation J:48084
abnormal somite development J:48084
decreased angiogenesis J:48084
decreased embryo size J:48084
disorganized yolk sac vascular plexus J:48084
hypoxia J:48084
increased embryonic tissue cell apoptosis J:48084
Hif1atm3Rsjo/Hif1atm3Rsjo
involves: 129S1/Sv * 129X1/SvJ 		abnormal gluconeogenesis J:152724
decreased cell proliferation J:116762
decreased circulating glucose level J:152724
decreased hepatocyte proliferation J:152724
decreased liver glycogen level J:152724
delayed liver regeneration J:152724
early cellular replicative senescence J:116762
increased cellular sensitivity to gamma-irradiation J:116762
Hif1atm3Rsjo/Hif1atm3Rsjo
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal leukocyte physiology J:117348
abnormal macrophage physiology J:107682
decreased inflammatory response J:107682
decreased susceptibility to induced arthritis J:107682
decreased tumor necrosis factor secretion J:107682
impaired macrophage chemotaxis J:107682
increased susceptibility to injury J:117348
Hif1atm3Rsjo/Hif1atm3Rsjo
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal body temperature J:148597
abnormal systemic arterial blood pressure J:148597
decreased interleukin-1 alpha secretion J:148597
decreased interleukin-1 beta secretion J:148597
decreased interleukin-6 secretion J:148597
decreased interleukin-12 secretion J:148597
decreased susceptibility to endotoxin shock J:148597
decreased susceptibility to xenobiotic induced morbidity/mortality J:148597
decreased tumor necrosis factor secretion J:148597
Hif1atm3Rsjo/Hif1atm3Rsjo
Myl2tm1(cre)Krc/Myl2+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		abnormal cardiac muscle relaxation J:118455
abnormal coronary vessel morphology J:118455
abnormal heart left ventricle morphology J:118455
abnormal heart left ventricle pressure J:118455
abnormal myocardial fiber physiology J:118455
abnormal physiological response to xenobiotic J:118455
cardiac hypertrophy J:118455
decreased cardiac muscle contractility J:118455
increased heart left ventricle wall thickness J:118455
increased heart left ventricle weight J:118455
thick interventricular septum J:118455
Hif1atm3Rsjo/Hif1atm3Rsjo
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
involves: 129S1/Sv * 129X1/SvJ 		normal immune system phenotype J:119731
Hif1atm3Rsjo/Hif1atm3Rsjo
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1Tg(Alb-cre)21Mgn
B6.Cg-Hif1atm3Rsjo Speer6-ps1Tg(Alb-cre)21Mgn 		decreased physiological sensitivity to xenobiotic J:211093
normal vision/eye phenotype J:211093
Hif1atm3Rsjo/Hif1atm3Rsjo
Tg(Camk2a-cre)1Szi/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal behavior J:121971
abnormal brain vasculature morphology J:121971
abnormal physiological response to xenobiotic J:121971
decreased susceptibility to ischemic brain injury J:121971
hydrocephaly J:121971
increased cerebral infarct size J:121971
increased susceptibility to induced morbidity/mortality J:121971
increased susceptibility to ischemic brain injury J:121971
Hif1atm3Rsjo/Hif1atm3Rsjo
Tg(Camk2a-cre)2Szi/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal behavior J:121971
abnormal physiological response to xenobiotic J:121971
decreased susceptibility to ischemic brain injury J:98637
hydrocephaly J:121971
increased cerebral infarct size J:121971
increased susceptibility to induced morbidity/mortality J:121971
increased susceptibility to ischemic brain injury J:121971
Hif1atm3Rsjo/Hif1atm3Rsjo
Tg(CD68-icre)1Bwlx/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal mortality/aging J:194598
Hif1atm3Rsjo/Hif1atm3Rsjo
Tg(Ckmm-cre)5Khn/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N 		abnormal exercise endurance J:97761
abnormal glucose homeostasis J:97761
abnormal innervation pattern to muscle J:97761
abnormal muscle physiology J:97761
increased circulating creatine kinase level J:97761
Hif1atm3Rsjo/Hif1atm3Rsjo
Tg(Col2a1-cre)1Rsjo/?
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal angiogenesis J:72709
abnormal cartilage development J:72709
abnormal long bone epiphyseal plate proliferative zone J:72709
abnormal long bone hypertrophic chondrocyte zone J:72709
abnormal long bone morphology J:72709
abnormal sternocostal joint morphology J:72709
abnormal sternum morphology J:72709
abnormal thoracic cage shape J:72709
abnormal tracheal cartilage morphology J:72709
abnormal tracheal ciliated epithelium morphology J:72709
decreased embryo size J:72709
decreased length of long bones J:72709
disorganized long bone epiphyseal plate J:72709
increased long bone epiphyseal plate size J:72709
neonatal lethality, complete penetrance J:72709
respiratory failure J:72709
short limbs J:72709
Hif1atm3Rsjo/Hif1atm3Rsjo
Tg(Fabp1-cre)1Jig/0
involves: 129S1/Sv * 129X1/SvJ * BALB/c * FVB/N 		abnormal digestive system physiology J:93476
increased susceptibility to induced colitis J:93476
Hif1atm3Rsjo/Hif1atm3Rsjo
Tg(Itgax-cre)1-1Reiz/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal cell physiology J:187773
abnormal dendritic cell number J:187773
abnormal leukocyte migration J:187773
normal immune system phenotype J:187773
Hif1atm3Rsjo/Hif1atm3Rsjo
Tg(Lck-cre)1Jtak/0
involves: 129S1/Sv * 129X1/SvJ 		increased interferon-gamma secretion J:117857
Hif1atm3Rsjo/Hif1atm3Rsjo
Tg(MMTV-cre)1Mam/0
involves: 129S1/Sv * 129X1/SvJ * CD-1 * FVB 		abnormal lactation J:82618
abnormal mammary gland alveolus morphology J:82618
abnormal mammary gland epithelium morphology J:82618
abnormal mammary gland morphology J:82618
abnormal milk composition J:82618
abnormal milk sodium level J:82618
normal cardiovascular system phenotype J:82618
Hif1atm3Rsjo/Hif1atm3Rsjo
Tg(Pax6-cre,GFP)1Pgr/0
involves: 129S1/Sv * 129X1/SvJ * FVB 		abnormal lens fiber morphology J:141905
abnormal lens morphology J:141905
increased lens fiber apoptosis J:141905
small lens J:141905
Hif1atm3Rsjo/Hif1atm3Rsjo
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0
involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal pulmonary alveolus epithelial cell morphology J:143384
abnormal pulmonary alveolus morphology J:143384
abnormal surfactant secretion J:143384
abnormal type II pneumocyte morphology J:143384
atelectasis J:143384
cyanosis J:143384
increased lung weight J:143384
neonatal lethality, incomplete penetrance J:143384
respiratory distress J:143384
thick pulmonary interalveolar septum J:143384
Hif1atm3Rsjo/Hif1atm3Rsjo
Tg(Tal1-cre/ERT)42-056Jrg/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal B cell differentiation J:192126
abnormal hematopoietic stem cell physiology J:192126
abnormal T cell differentiation J:192126
decreased common myeloid progenitor cell number J:192126
increased hematopoietic stem cell number J:192126
Hif1atm3Rsjo/Hif1atm3Rsjo
Tg(Tek-cre)1Ywa/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal vascular endothelial cell migration J:94773
decreased angiogenesis J:94773
decreased tumor growth/size J:94773
decreased vascular endothelial cell proliferation J:94773
delayed wound healing J:94773
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory