Rfx2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rfx2
regulatory factor X, 2 (influences HLA class II expression)
MGI:106583

30 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rfx2^{Gt(IST10638H11)Tigm}/Rfx2^{Gt(IST10638H11)Tigm} either: C57BL/6N-Rfx2^{Gt(IST10638H11)Tigm} or (involves: C57BL/6N * CD-1)	abnormal spermatid morphology	J:227136
	abnormal spermatogenesis	J:227136
	abnormal spermiogenesis	J:227136
	normal behavior/neurological phenotype	J:227136
	normal embryo phenotype	J:227136
	increased Leydig cell number	J:227136
	Leydig cell hypertrophy	J:227136
	male infertility	J:227136
	multinucleated giant male germ cells	J:227136
Rfx2^tm1.1Wrth/Rfx2^tm1.1Wrth involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	abnormal acrosome assembly	J:228765
	abnormal acrosome morphology	J:228765
	abnormal cauda epididymis morphology	J:228765
	abnormal ectoplasmic specialization morphology	J:228765
	abnormal Golgi apparatus morphology	J:228765
	abnormal sperm axoneme morphology	J:228765
	arrest of spermiogenesis	J:228765
	normal cellular phenotype	J:228765
	detached acrosome	J:228765
	ectopic manchette	J:228765
	normal embryo phenotype	J:228765
	male infertility	J:228765
	multinucleated giant male germ cells	J:228765
	normal reproductive system phenotype	J:228765
	small testis	J:228765
Rfx2^tm1.2Wrth/Rfx2^tm1.2Wrth involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	abnormal acrosome assembly	J:228765
	abnormal acrosome morphology	J:228765
	abnormal cauda epididymis morphology	J:228765
	abnormal ectoplasmic specialization morphology	J:228765
	abnormal Golgi apparatus morphology	J:228765
	abnormal sperm axoneme morphology	J:228765
	arrest of spermiogenesis	J:228765
	normal cellular phenotype	J:228765
	detached acrosome	J:228765
	ectopic manchette	J:228765
	normal embryo phenotype	J:228765
	male infertility	J:228765
	multinucleated giant male germ cells	J:228765
	normal reproductive system phenotype	J:228765
	small testis	J:228765
Rfx2^tm1Hncs/Rfx2^tm1Hncs involves: 129S6/SvEvTac * C57BL/6	abnormal acrosome morphology	J:230575
	abnormal epididymis morphology	J:230575
	abnormal manchette morphology	J:230575
	abnormal sperm axoneme morphology	J:230575
	abnormal spermatid morphology	J:230575
	abnormal spermatogenesis	J:230575
	arrest of spermatogenesis	J:230575
	arrest of spermiogenesis	J:230575
	azoospermia	J:230575
	decreased body size	J:230575
	normal growth/size/body region phenotype	J:230575
	increased male germ cell apoptosis	J:230575
	male infertility	J:230575
	multinucleated giant male germ cells	J:230575
	postnatal growth retardation	J:230575
	premature death	J:230575
	normal reproductive system phenotype	J:230575
	small testis	J:230575

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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