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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Six5
sine oculis-related homeobox 5
MGI:106220
27 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Tg(DMWD,DMPK*,SIX5)328Ggo/0
involves: C57BL/6 * DBA/2
abnormal skeletal muscle fiber morphology J:73187
abnormal tooth morphology J:73187
centrally nucleated skeletal muscle fibers J:73187
decreased body size J:73187
decreased body weight J:73187
impaired muscle relaxation J:73187
increased variability of skeletal muscle fiber size J:73187
normal reproductive system phenotype J:73187
skeletal muscle fibrosis J:73187
Tg(DMWD,DMPK*,SIX5)328Ggo/Tg(DMWD,DMPK*,SIX5)328Ggo
involves: 129 * C57BL/6 * DBA/2 * FVB/N
decreased body size J:121539
postnatal growth retardation J:121539
premature death J:121539
Tg(DMWD,DMPK*,SIX5)328Ggo/Tg(DMWD,DMPK*,SIX5)328Ggo
involves: C57BL/6 * DBA/2
abnormal brain morphology J:73187
abnormal diaphragm morphology J:196337
abnormal neuromuscular synapse morphology J:196337
abnormal phrenic nerve morphology J:196337
abnormal respiratory function J:196337
abnormal skeletal muscle fiber type ratio J:196337
abnormal tooth morphology J:73187
decreased blood oxygen saturation level J:196337
decreased body size J:73187
decreased pulmonary respiratory rate J:196337
impaired muscle relaxation J:73187
increased variability of skeletal muscle fiber size J:73187
lethality, incomplete penetrance J:73187
premature death J:73187
rectal prolapse J:73187
Tg(DMWD,DMPK*,SIX5)1177Ggo/0
involves: C57BL/6 * DBA/2
abnormal skeletal muscle fiber morphology J:73187
abnormal tooth morphology J:73187
centrally nucleated skeletal muscle fibers J:73187
decreased body size J:73187
decreased litter size J:73187
increased mitochondrial number J:73187
increased mitochondrial size J:73187
increased variability of skeletal muscle fiber size J:73187
muscular atrophy J:73187
skeletal muscle degeneration J:73187
skeletal muscle fibrosis J:73187
Tg(DMWD,DMPK*,SIX5)1177Ggo/Tg(DMWD,DMPK*,SIX5)1177Ggo
involves: C57BL/6 * DBA/2
abnormal brain morphology J:73187
normal craniofacial phenotype J:73187
decreased body size J:73187
impaired muscle relaxation J:73187
increased variability of skeletal muscle fiber size J:73187

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory