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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
MGI:106217
19 phenotypes from 6 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Cacna1etm1.1Beck/Cacna1etm1.1Beck
involves: 129P2/OlaHsd * C57BL/6
decreased channel response intensity J:105917
increased channel response threshold J:105917
Cacna1etm1.1Tsch/Cacna1etm1.1Tsch
involves: BALB/cJ * C57BL/6
decreased glucagon secretion J:101873
decreased insulin secretion J:95636
decreased physiological sensitivity to xenobiotic J:101873
hyperglycemia J:95636
impaired glucose tolerance J:95636
increased body weight J:101873
increased circulating glucose level J:101873
Cacna1etm1.1Tsch/Cacna1etm1.1Tsch
involves: C57BL/6
abnormal glucagon secretion J:95377
abnormal pancreatic beta cell physiology J:95377
decreased circulating glucagon level J:95377
decreased insulin secretion J:95377
decreased pancreatic alpha cell number J:95377
impaired glucose tolerance J:95377
increased circulating glucose level J:95377
Cacna1etm1Hssh/Cacna1etm1Hssh
involves: 129S4/SvJae * C57BL/6J
abnormal channel response J:81788
abnormal fear/anxiety-related behavior J:81788
increased thigmotaxis J:81788
Cacna1etm1Rjml/Cacna1etm1Rjml
involves: 129S1/Sv * C57BL/6J
no abnormal phenotype detected J:66144
Cacna1etm1Tsch/Cacna1etm1Tsch
involves: C57BL/6
no abnormal phenotype detected J:95636
Cacna1etm1Ttan/Cacna1etm1Ttan
involves: 129S4/SvJae * C57BL/6
abnormal fear/anxiety-related behavior J:62285
abnormal motor capabilities/coordination/movement J:62285
abnormal sensory capabilities/reflexes/nociception J:62285

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory