Cacna1e Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
MGI:106217

19 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cacna1e^tm1.1Beck/Cacna1e^tm1.1Beck involves: 129P2/OlaHsd * C57BL/6	decreased channel response intensity	J:105917
	increased channel response threshold	J:105917
Cacna1e^tm1.1Tsch/Cacna1e^tm1.1Tsch involves: BALB/cJ * C57BL/6	decreased glucagon secretion	J:101873
	decreased insulin secretion	J:95636
	decreased physiological sensitivity to xenobiotic	J:101873
	hyperglycemia	J:95636
	impaired glucose tolerance	J:95636
	increased body weight	J:101873
	increased circulating glucose level	J:101873
Cacna1e^tm1.1Tsch/Cacna1e^tm1.1Tsch involves: C57BL/6	abnormal glucagon secretion	J:95377
	abnormal pancreatic beta cell physiology	J:95377
	decreased circulating glucagon level	J:95377
	decreased insulin secretion	J:95377
	decreased pancreatic alpha cell number	J:95377
	impaired glucose tolerance	J:95377
	increased circulating glucose level	J:95377
Cacna1e^tm1Hssh/Cacna1e^tm1Hssh involves: 129S4/SvJae * C57BL/6J	abnormal channel response	J:81788
	abnormal fear/anxiety-related behavior	J:81788
	increased thigmotaxis	J:81788
Cacna1e^tm1Rjml/Cacna1e^tm1Rjml involves: 129S1/Sv * C57BL/6J	no abnormal phenotype detected	J:66144
Cacna1e^tm1Tsch/Cacna1e^tm1Tsch involves: C57BL/6	no abnormal phenotype detected	J:95636
Cacna1e^tm1Ttan/Cacna1e^tm1Ttan involves: 129S4/SvJae * C57BL/6	abnormal fear/anxiety-related behavior	J:62285
	abnormal motor capabilities/coordination/movement	J:62285
	abnormal sensory capabilities/reflexes/nociception	J:62285

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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