98 phenotypes from 13 alleles in 14 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Efnb2tm1.1Henk/Efnb2+ either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)	normal reproductive system phenotype	J:91491
Efnb2tm1.1Henk/Efnb2+ involves: 129 * CD-1	abnormal endolymph physiology	J:116671
	circling	J:116671
	decreased posterior semicircular canal size	J:116671
	decreased superior semicircular canal size	J:116671
	head bobbing	J:116671
	small endolymphatic duct	J:116671
Efnb2tm1.1Henk/Efnb2tm1.1Henk either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)	abnormal angiogenesis	J:91492
	abnormal blood vessel morphology	J:91492
	abnormal cardiovascular development	J:91492
	abnormal heart morphology	J:91492
	abnormal vitelline vascular remodeling	J:91492
	abnormal vitelline vasculature morphology	J:91492
	decreased embryo size	J:91492
	embryonic growth retardation	J:91492
	embryonic lethality during organogenesis, complete penetrance	J:91492
	enlarged pericardium	J:91492
Efnb2tm1.1Jwu/Efnb2tm1.1Jwu Tg(Lck-cre)I540Jxm/0 B6.Cg-Efnb2tm1.1Jwu Tg(Lck-cre)I540Jxm	normal immune system phenotype	J:178148
Efnb2tm1And/Efnb2tm1And involves: 129S7/SvEvBrd	abnormal angiogenesis	J:75288
	abnormal cardinal vein morphology	J:75288
	abnormal endocardium morphology	J:75288
	abnormal heart ventricle morphology	J:119151
	abnormal myocardium layer morphology	J:119151
	abnormal vitelline vasculature morphology	J:75288
	absent myocardial trabeculae	J:75288
	normal cardiovascular system phenotype	J:75288
	embryonic growth retardation	J:75288
	embryonic lethality during organogenesis, complete penetrance	J:75288
	enlarged heart	J:75288
Efnb2tm1And/Efnb2tm1And involves: 129S7/SvEvBrd * C57BL/6	abnormal angiogenesis	J:74909
	abnormal anterior cardinal vein morphology	J:74909
	abnormal developmental vascular remodeling	J:74909
	abnormal heart looping	J:74909
	abnormal intersomitic vessel morphology	J:74909
	abnormal vitelline vasculature morphology	J:74909
	absent myocardial trabeculae	J:74909
	decreased embryo size	J:74909
	enlarged heart	J:74909
Efnb2tm1And/Efnb2tm2And Tg(Tek-cre)12Flv/0 involves: 129S7/SvEvBrd * C57BL/6	abnormal angiogenesis	J:74909
	abnormal developmental vascular remodeling	J:74909
	abnormal heart looping	J:74909
	abnormal intersomitic vessel morphology	J:74909
	abnormal vascular development	J:74909
	abnormal vitelline vasculature morphology	J:74909
	absent myocardial trabeculae	J:74909
	decreased embryo size	J:74909
	embryonic growth arrest	J:74909
	embryonic lethality during organogenesis, complete penetrance	J:74909
	enlarged heart	J:74909
Efnb2tm1Henk/Efnb2+ either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)	abnormal anogenital distance	J:91491
	abnormal penis morphology	J:91491
	abnormal septation of the cloaca	J:91491
	hypospadia	J:91491
	male infertility	J:91491
	splayed clitoris	J:91491
Efnb2tm1Henk/Efnb2+ involves: 129 * CD-1	abnormal endolymph physiology	J:116671
	abnormal vestibular endolymph ionic homeostasis	J:116671
	abnormal vestibular endolymph physiology	J:116671
	circling	J:116671
	cleft palate	J:173636
	decreased posterior semicircular canal size	J:116671
	decreased superior semicircular canal size	J:116671
	head bobbing	J:116671
	small endolymphatic duct	J:116671
Efnb2tm1Henk/Efnb2+ Not Specified	abnormal axon morphology	J:176056
Efnb2tm1Henk/Efnb2tm1Henk either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)	abnormal anterior commissure pars posterior morphology	J:91492
	abnormal axon guidance	J:91492
	abnormal heart valve morphology	J:91492
	abnormal septation of the cloaca	J:91491
	abnormal urethra morphology	J:91491
	anal atresia	J:91491
	aortic valve hyperplasia	J:91492
	normal cardiovascular system phenotype	J:91492
	embryonic lethality between implantation and placentation, incomplete penetrance	J:91492
	enlarged aortic valve	J:91492
	enlarged pulmonary valve	J:91492
	hypospadia	J:91491
	neonatal lethality, complete penetrance	J:91491, J:91492
	persistent cloaca	J:91491
	pulmonary valve hyperplasia	J:91492
	splayed clitoris	J:91491
	thick aortic valve	J:91492
	thick mitral valve cusps	J:91492
	thick pulmonary valve	J:91492
Efnb2tm1Henk/Efnb2tm1Henk involves: 129 * CD-1	abnormal common crus morphology	J:116671
	abnormal semicircular canal morphology	J:116671
	cleft palate	J:173636
	decreased endolymph production	J:116671
	dilated endolymphatic duct	J:116671
	dilated endolymphatic sac	J:116671
	neonatal lethality, complete penetrance	J:173636
	tracheoesophageal fistula	J:173636
Efnb2tm1Henk/Efnb2tm1Henk Tbx4tm1(cre)Tmj/Tbx4+ involves: 129S1/Sv * 129X1/SvJ	normal nervous system phenotype	J:176643
Efnb2tm1Henk/Efnb2tm2.1Henk involves: 129 * CD-1	hypospadia	J:173636
Efnb2tm1Henk/Efnb2tm3.1Henk involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal axon morphology	J:176056
	hypospadia	J:173636
Efnb2tm1Kln/Efnb2tm1Kln involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal angiogenesis	J:67296
	abnormal cardinal vein morphology	J:67296
	abnormal intersomitic vessel morphology	J:67296
	abnormal neural crest cell migration	J:67296
	abnormal second pharyngeal arch morphology	J:67296
	absent pharyngeal arch arteries	J:67296
	absent second pharyngeal arch	J:67296
	normal embryo phenotype	J:67296
	embryonic growth retardation	J:67296
	embryonic lethality during organogenesis, complete penetrance	J:67296
	small second pharyngeal arch	J:67296
Efnb2tm2.1Henk/Efnb2tm2.1Henk involves: 129 * CD-1	normal digestive/alimentary phenotype	J:173636
	premature death	J:173636
Efnb2tm2.1Kln/Efnb2tm2.1Kln involves: 129S1/Sv * 129X1/SvJ * C57BL/6	no abnormal phenotype detected	J:67296
Efnb2tm2And/Efnb2tm2And Tg(CAG-cre/Esr1*)1Egwa/0 involves: 129S7/SvEvBrd * C57BL/6 * DBA/2	abnormal angiogenesis	J:157054
	abnormal skin physiology	J:157054
	flaky skin	J:157054
	hyperkeratosis	J:157054
	normal integument phenotype	J:157054
	postnatal growth retardation	J:157054
	postnatal lethality, complete penetrance	J:157054
	retarded hair growth	J:157054
	small hair follicles	J:157054
	thick epidermis	J:157054
	thin hypodermis	J:157054
Efnb2tm2Sor/Efnb2tm2Sor involves: 129S4/SvJaeSor	embryonic lethality, complete penetrance	J:115952
Efnb2tm2Sor/Efnb2tm2Sor involves: 129S4/SvJaeSor * C57BL/6J	abnormal cranial neural crest cell migration	J:143845
	abnormal dorsal-ventral polarity of the somites	J:143845
	abnormal rostral-caudal patterning of the somites	J:143845
	abnormal somite development	J:143845
	abnormal trunk neural crest cell migration	J:143845
	decreased cranial neural crest cell number	J:143845
	embryonic lethality during organogenesis, complete penetrance	J:143845
	increased cranial neural crest cell apoptosis	J:143845
	small first pharyngeal arch	J:143845
	small trigeminal ganglion	J:143845
Efnb2tm3.1Henk/Efnb2+ involves: 129S1/Sv * 129X1/SvJ	abnormal axon morphology	J:176056
Efnb2tm3.1Henk/Efnb2tm3.1Henk involves: 129S1/Sv * 129X1/SvJ * CD-1	normal digestive/alimentary phenotype	J:173636
	premature death	J:173636
Efnb2tm3.1Kln/Efnb2tm3.1Kln involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal anterior cardinal vein morphology	J:67296
	abnormal intersomitic vessel morphology	J:67296
	abnormal vitelline vascular remodeling	J:67296
	distended pericardium	J:67296
	normal embryo phenotype	J:67296
	embryonic growth retardation	J:67296
	embryonic lethality during organogenesis, complete penetrance	J:67296
	small pharyngeal arch	J:67296
Efnb2tm4Kln/Efnb2tm4Kln Tg(Camk2a-cre)159Kln/0 involves: 129P2/OlaHsd * C57BL/6	normal behavior/neurological phenotype	J:87398
	normal nervous system phenotype	J:87398
	reduced long-term potentiation	J:87398
Efnb2tm4Kln/Efnb2tm4Kln Tg(Nes-cre)1Kln/0 involves: 129P2/OlaHsd * C57BL/6	abnormal long-term depression	J:87398
	normal nervous system phenotype	J:87398
Efnb2tm5Kln/Efnb2tm5Kln involves: C57BL/6	chylothorax	J:95885
	postnatal lethality, complete penetrance	J:95885