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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
MGI:105089
50 phenotypes from 3 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Hsd17b4em1(IMPC)Tcp/Hsd17b4em1(IMPC)Tcp
C57BL/6N-Hsd17b4em1(IMPC)Tcp/Tcp
abnormal eye morphology J:211773
abnormal spleen morphology J:211773
abnormal sternum morphology J:211773
enlarged adrenal glands J:211773
increased or absent threshold for auditory brainstem response J:211773
preweaning lethality, incomplete penetrance J:211773
small uterus J:211773
Hsd17b4tm1Baes/Hsd17b4tm1Baes
involves: 129S1/Sv * 129X1/SvJ
abnormal bile salt level J:99925
abnormal epididymis morphology J:108368
abnormal gait J:201698
abnormal gametogenesis J:108368
abnormal intestinal absorption J:62314
abnormal lipid homeostasis J:104835
abnormal lipid level J:62314
abnormal male germ cell morphology J:108368
abnormal male reproductive system morphology J:108368
abnormal seminiferous tubule morphology J:108368
abnormal spermatid morphology J:108368
abnormal spermatogenesis J:108368
abnormal testis morphology J:108368
astrocytosis J:201698
ataxia J:62314, J:201698
axon degeneration J:201698
cataract J:62314
decreased body weight J:62314
impaired coordination J:201698
increased anxiety-related response J:201698
increased fatty acid level J:201698
lethargy J:201698
male infertility J:108368
microgliosis J:201698
normal nervous system phenotype J:104835
postnatal growth retardation J:62314
postnatal lethality, incomplete penetrance J:62314
premature death J:201698
Purkinje cell degeneration J:201698
reduced male fertility J:62314
seminiferous tubule degeneration J:108368
small testis J:108368
tremors J:201698
Hsd17b4tm2Baes/Hsd17b4tm2Baes
involves: 129 * C57BL/6
no abnormal phenotype detected J:201698
Hsd17b4tm2Baes/Hsd17b4tm2Baes
Cnptm1(cre)Kan/Cnp+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
normal behavior/neurological phenotype J:201698
normal growth/size/body region phenotype J:201698
increased fatty acid level J:201698
normal nervous system phenotype J:201698
normal reproductive system phenotype J:201698
Hsd17b4tm2Baes/Hsd17b4tm2Baes
Tg(Nes-cre)1Kln/0
involves: 129 * C57BL/6 * SJL
abnormal gait J:201698
ataxia J:201698
axon degeneration J:201698
cerebellum atrophy J:201698
decreased body weight J:201698
decreased litter size J:201698
demyelination J:201698
impaired coordination J:201698
increased anxiety-related response J:201698
increased fatty acid level J:201698
male infertility J:201698
microgliosis J:201698
neuron degeneration J:201698
postnatal growth retardation J:201698
premature death J:201698
Purkinje cell degeneration J:201698
reduced female fertility J:201698
short stride length J:201698
tremors J:201698

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory