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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pdcd1
programmed cell death 1
MGI:104879
47 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Btlatm1Kmm/Btlatm1Kmm
Pdcd1tm1Hon/Pdcd1tm1Hon
B6.129S-Pdcd1tm1Hon Btlatm1Kmm 		decreased length of allograft survival J:119356
increased T cell proliferation J:119356
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Pdcd1tm1Hon/Pdcd1tm1Hon
involves: 129S2/SvPas * 129S4/SvJae * BALB/c 		abnormal cytokine level J:207275
abnormal urinary bladder urothelium morphology J:207275
abnormal urine cytokine level J:207275
decreased body weight J:207275
increased autoantibody level J:207275
oliguria J:207275
urinary bladder inflammation J:207275
Foxp3tm2.1(EGFP/cre)Shori/Foxp3tm2.1(EGFP/cre)Shori
Pdcd1tm1Hon/Pdcd1tm1Hon
involves: 129 * 129S2/SvPas * C57BL/6 		premature death J:234397
Foxp3tm2.1(EGFP/cre)Shori/Y
Pdcd1tm1Hon/Pdcd1tm1Hon
involves: 129 * 129S2/SvPas * C57BL/6 		decreased circulating lipase level J:234397
enlarged lymph nodes J:234397
enlarged spleen J:234397
increased effector memory T-helper cell number J:234397
increased susceptibility to autoimmune disorder J:234397
lymph node hyperplasia J:234397
pancreas atrophy J:234397
pancreas inflammation J:234397
premature death J:234397
spleen hyperplasia J:234397
Pdcd1tm1.1Liux/Pdcd1tm1.1Liux
Tg(MMTV-PyVT)634Mul/0
involves: C57BL/6 * FVB/N 		decreased interleukin-17 secretion J:190150
decreased regulatory T cell number J:190150
decreased T-helper 2 cell number J:190150
decreased T-helper 17 cell number J:190150
decreased tumor growth/size J:190150
extended life span J:190150
increased apoptosis J:190150
increased interferon-gamma secretion J:190150
increased interleukin-2 secretion J:190150
increased T-helper 1 cell number J:190150
increased tumor latency J:190150
increased tumor necrosis factor secretion J:190150
Pdcd1tm1.1Shr/Pdcd1tm1.1Shr
Tg(TcraTcrb)1100Mjb/0
involves: C57BL/6 		abnormal immune tolerance J:153040
decreased T cell proliferation J:153040
increased susceptibility to autoimmune diabetes J:153040
increased T cell proliferation J:153040
insulitis J:153040
pancreas inflammation J:153040
vascular inflammation J:153040
Pdcd1tm1Hon/Pdcd1tm1Hon
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129S2/SvPas 		decreased susceptibility to experimental autoimmune encephalomyelitis J:140751
Pdcd1tm1Hon/Pdcd1tm1Hon
Vsirtm1Lex/Vsirtm1Lex
involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 		abnormal T cell activation J:222944
hepatic necrosis J:222944
normal immune system phenotype J:222944
increased IgA level J:222944
increased IgM level J:222944
increased inflammatory response J:222944
increased interferon-gamma secretion J:222944
increased interleukin-17 secretion J:222944
increased tumor necrosis factor secretion J:222944
pancreas necrosis J:222944
pulmonary necrosis J:222944
Pdcd1tm1Hon/Pdcd1tm1Hon
Vsirtm1Lex/Vsirtm1Lex
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 		increased susceptibility to experimental autoimmune encephalomyelitis J:222944
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory