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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lta
lymphotoxin A
MGI:104797
92 phenotypes from 11 alleles in 23 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Lta/Tnftm1Eug/Lta/Tnftm1Eug
B6.129-Lta/Tnftm1Eug 		abnormal sleep pattern J:103266
decreased circulating interferon-gamma level J:115034
decreased IgG1 level J:115034
decreased IgG2a level J:115034
decreased IgG3 level J:115034
decreased interferon-gamma secretion J:115034
decreased susceptibility to induced arthritis J:115034
impaired macrophage phagocytosis J:115034
increased IgM level J:115034
increased susceptibility to bacterial infection J:115034
increased susceptibility to bacterial infection induced morbidity/mortality J:115034
Lta/Tnftm1Eug/Lta/Tnftm1Eug
involves: 129 		abnormal humoral immune response J:31129
abnormal spleen marginal zone morphology J:31129
abnormal spleen morphology J:31129
absent lymph nodes J:31129
absent Peyer's patches J:31129
decreased IgA level J:31129
decreased susceptibility to induced morbidity/mortality J:31129
decreased T cell number J:31129
increased B cell number J:31129
increased leukocyte cell number J:31129
increased susceptibility to induced morbidity/mortality J:31129
increased susceptibility to parasitic infection J:31129
increased susceptibility to Poxviridae infection J:31129
increased susceptibility to Riboviria infection J:31129
Lta/Tnftm1Eug/Lta/Tnftm1Eug
involves: 129 * C57BL/6J 		enlarged liver J:112797
hepatic steatosis J:112797
increased body length J:112797
increased body mass index J:112797
increased body weight J:112797
increased heart weight J:112797
increased liver weight J:112797
increased spleen weight J:112797
increased susceptibility to diet-induced obesity J:112797
long tibia J:112797
Lta/Tnftm1Eug/Lta/Tnftm1Eug
involves: 129/Sv * C57BL/6 		decreased susceptibility to experimental autoimmune encephalomyelitis J:115225
decreased susceptibility to parasitic infection J:37696
increased susceptibility to induced morbidity/mortality J:61314
increased susceptibility to injury J:61314
Lta/Tnftm1Fda/Lta+
involves: 129S1/Sv * 129X1/SvJ 		decreased susceptibility to endotoxin shock J:39519
decreased tumor necrosis factor secretion J:39519
increased susceptibility to bacterial infection J:39519
Lta/Tnftm1Fda/Lta/Tnftm1Fda
involves: 129S1/Sv * 129X1/SvJ 		decreased susceptibility to endotoxin shock J:39519
decreased tumor necrosis factor secretion J:39519
increased susceptibility to bacterial infection J:39519
Lta/Tnftm1Jods/Lta/Tnftm1Jods
C57BL/6-Lta/Tnftm1Jods 		abnormal spleen white pulp morphology J:78229
decreased susceptibility to experimental autoimmune encephalomyelitis J:47428
Lta/Tnftm1Jods/Lta/Tnftm1Jods
C57BL/6J-Lta/Tnftm1Jods 		abnormal spleen morphology J:43602
abnormal spleen white pulp morphology J:43602
absent lymph nodes J:43602
absent Peyer's patches J:43602
decreased immunoglobulin level J:43602
enlarged spleen J:43602
increased leukocyte cell number J:43602
Lta/Tnftm1Jods/Lta/Tnftm1Jods
involves: C57BL/6 		abnormal gamma-delta T cell morphology J:169863
Ltahlb382/Ltahlb382
C57BL/6J-Ltahlb382/J 		abnormal immune system organ morphology J:134498
absent lymph nodes J:134498
absent marginal zone B cells J:134498
absent mesenteric lymph nodes J:134498
absent Peyer's patches J:134498
absent spleen germinal center J:134498
absent spleen marginal zone J:134498
decreased NK cell number J:134498
decreased transitional stage B cell number J:134498
increased B-1b cell number J:134498
increased leukocyte cell number J:82961
liver inflammation J:134498
lung inflammation J:134498
Ltatm1.1(KOMP)Vlcg/Ltatm1.1(KOMP)Vlcg
C57BL/6N-Ltatm1.1(KOMP)Vlcg/MbpMmucd 		increased bronchoconstrictive response J:211773
increased pulmonary ventilation J:211773
Ltatm1.1(KOMP)Vlcg/Ltatm1.1(KOMP)Vlcg
C57BL/6N-Ltatm1.1(KOMP)Vlcg/Ucd 		abnormal heart morphology J:211773
decreased monocyte cell number J:211773
enlarged heart J:211773
increased eosinophil cell number J:211773
increased leukocyte cell number J:211773
increased lymphocyte cell number J:211773
increased neutrophil cell number J:211773
Ltatm1.1Sned/Ltatm1.1Sned
B6.129-Ltatm1.1Sned 		abnormal circulating tumor necrosis factor level J:109621
abnormal class switch recombination J:109621
abnormal humoral immune response J:109621
abnormal immune system morphology J:109621
abnormal lymphopoiesis J:109621
absent Peyer's patches J:109621
decreased spleen white pulp amount J:109621
enlarged spleen J:109621
increased susceptibility to bacterial infection induced morbidity/mortality J:109621
Ltatm1Dch/Ltatm1Dch
B6.129S2-Ltatm1Dch 		abnormal class switch recombination J:80616
abnormal cytokine secretion J:95222
abnormal immune serum protein physiology J:80616
abnormal mucosa-associated lymphoid tissue morphology J:95222
abnormal spleen morphology J:80616
absent Peyer's patches J:80616
absent spleen germinal center J:80616
absent spleen marginal zone J:80616
decreased IgG level J:80616
decreased spleen B cell follicle number J:80616
decreased spleen white pulp amount J:80616
increased IgM level J:80616
increased leukocyte cell number J:80616
Ltatm1Dch/Ltatm1Dch
B6.129S2-Ltatm1Dch/J 		abnormal lymph organ development J:73100
Ltatm1Dch/Ltatm1Dch
involves: 129S2/SvPas 		abnormal lymphocyte morphology J:173115
abnormal thymus epithelium morphology J:173115
abnormal thymus medulla morphology J:173115
small thymus medulla J:173115
Ltatm1Dch/Ltatm1Dch
involves: 129S2/SvPas * C57BL/6 		abnormal class switch recombination J:109621
abnormal humoral immune response J:39746
abnormal leukocyte cell number J:17976
abnormal lymph node morphology J:17976
abnormal lymph node primary follicle morphology J:109621
abnormal spleen morphology J:17976, J:39746
abnormal spleen periarteriolar lymphoid sheath morphology J:17976
absent axillary lymph nodes J:17976
absent cervical lymph nodes J:17976
absent inguinal lymph nodes J:17976
absent mesenteric lymph nodes J:17976, J:39746
absent Peyer's patches J:17976
absent popliteal lymph nodes J:17976
absent spleen marginal zone J:17976
decreased interferon-gamma secretion J:109621
decreased spleen white pulp amount J:109621
decreased T cell number J:17976
decreased tumor necrosis factor secretion J:109621
increased B cell number J:17976
increased leukocyte cell number J:17976
increased susceptibility to induced morbidity/mortality J:109621
Ltatm1Dch/Ltatm1Dch
involves: 129S2/SvPas * C57BL/6J 		normal liver/biliary system phenotype J:112797
Ltatm1Jods/Ltatm1Jods
C57BL/6-Ltatm1Jods 		abnormal immune system organ morphology J:47428
abnormal spleen morphology J:47428
abnormal spleen white pulp morphology J:78229
absent peripheral lymph nodes J:47428
absent Peyer's patches J:47428
increased lymphocyte cell number J:47428
Ltatm1Jods/Ltatm1Jods
involves: C57BL/6 		abnormal thymus epithelium morphology J:125864
Ltatm1Tab/Ltatm1Tab
B6.129S2-Ltatm1Tab 		decreased susceptibility to parasitic infection J:121070
Ltatm1Tab/Ltatm1Tab
either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1) 		abnormal humoral immune response J:28061
absent lymph nodes J:28061
absent Peyer's patches J:28061
absent spleen marginal zone J:28061
decreased IgA level J:28061
decreased spleen white pulp amount J:28061
increased IgM level J:28061
increased leukocyte cell number J:28061
increased spleen weight J:28061
Ltatm1Tab/Ltatm1Tab
involves: 129S2/SvPas * C57BL/6 		decreased tumor necrosis factor secretion J:109621
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
B6.Cg-Ltb/Tnf/Ltatm1Dvk 		abnormal class switch recombination J:80616
abnormal spleen morphology J:80616
absent axillary lymph nodes J:80616
absent brachial lymph nodes J:80616
absent inguinal lymph nodes J:80616
absent lymph nodes J:80616
absent mesenteric lymph nodes J:80616
absent Peyer's patches J:80616
absent popliteal lymph nodes J:80616
absent spleen germinal center J:80616
absent spleen marginal zone J:80616
decreased IgG level J:80616
decreased spleen B cell follicle number J:80616
decreased spleen white pulp amount J:80616
increased leukocyte cell number J:80616
increased susceptibility to bacterial infection J:80616
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
involves: C57BL/6 		decreased spleen white pulp amount J:109621
Tg(Ins2-Lta)#Flv/0
involves: C57BL/6 		abnormal pancreatic islet morphology J:91820
insulitis J:91820
kidney inflammation J:91820
periinsulitis J:91820
Tg(Ins2-Lta)#Flv/0
involves: C57BL/6 * CBA 		insulitis J:127705
periinsulitis J:127705
Tg(Ins2-Lta)#Flv/0
involves: NOD 		abnormal pancreatic islet morphology J:91820
insulitis J:91820
kidney inflammation J:91820
periinsulitis J:91820
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory