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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ltb
lymphotoxin B
MGI:104796
49 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Ltbtm1Avt/Ltbtm1Avt
involves: 129P2/OlaHsd * C57BL/6 		abnormal adaptive immunity J:79129
abnormal spleen B cell follicle morphology J:79129
abnormal spleen follicular dendritic cell network J:79129
decreased marginal zone B cell number J:79129
decreased spleen germinal center number J:79129
decreased spleen germinal center size J:79129
small Peyer's patches J:79129
Cd19tm1(cre)Cgn/Cd19+
Ltbtm1Avt/Ltbtm1Avt
Tg(Lck-cre)1Jtak/?
involves: 129P2/OlaHsd * C57BL/6 		absent follicular dendritic cells J:79129
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
B6.Cg-Ltb/Tnf/Ltatm1Dvk 		abnormal class switch recombination J:80616
abnormal spleen morphology J:80616
absent axillary lymph nodes J:80616
absent brachial lymph nodes J:80616
absent inguinal lymph nodes J:80616
absent lymph nodes J:80616
absent mesenteric lymph nodes J:80616
absent Peyer's patches J:80616
absent popliteal lymph nodes J:80616
absent spleen germinal center J:80616
absent spleen marginal zone J:80616
decreased IgG level J:80616
decreased spleen B cell follicle number J:80616
decreased spleen white pulp amount J:80616
increased leukocyte cell number J:80616
increased susceptibility to bacterial infection J:80616
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
involves: C57BL/6 		decreased spleen white pulp amount J:109621
Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 		abnormal mesenteric lymph node morphology J:58981
abnormal spleen morphology J:58981
absent axillary lymph nodes J:58981
absent brachial lymph nodes J:58981
absent cervical lymph nodes J:58981
absent follicular dendritic cells J:58981
absent germinal center B cells J:58981
absent inguinal lymph nodes J:58981
absent peripheral lymph nodes J:58981
absent Peyer's patches J:58981
absent popliteal lymph nodes J:58981
absent spleen marginal zone J:58981
intermingled spleen red and white pulp J:58981
Ltbtm1Flv/Ltbtm1Flv
involves: 129S1/Sv * C57BL/6J 		abnormal humoral immune response J:39746
abnormal mesenteric lymph node morphology J:39746
abnormal spleen morphology J:39746
abnormal spleen red pulp morphology J:39746
abnormal spleen white pulp morphology J:39746
absent peripheral lymph nodes J:39746
absent Peyer's patches J:39746
decreased IgA level J:39746
increased susceptibility to xenobiotic induced morbidity/mortality J:91927
Ltbtm1Kpf/Ltbtm1Kpf
B6.129P2-Ltbtm1Kpf 		abnormal class switch recombination J:80616
abnormal colon morphology J:158663
abnormal spleen morphology J:80616
absent spleen marginal zone J:80616
colitis J:158663
decreased IgG level J:80616
decreased spleen B cell follicle number J:80616
decreased spleen white pulp amount J:80616
increased IgM level J:80616
increased leukocyte cell number J:80616
increased susceptibility to bacterial infection J:80616, J:158663
increased susceptibility to bacterial infection induced morbidity/mortality J:158663
weight loss J:158663
Ltbtm1Kpf/Ltbtm1Kpf
involves: 129P2/OlaHsd * C57BL/6 		abnormal liver morphology J:42508
abnormal lung morphology J:42508
abnormal mesenteric lymph node morphology J:42508, J:58981
abnormal spleen follicular dendritic cell network J:42508
abnormal spleen germinal center morphology J:42508
abnormal spleen marginal zone morphology J:42508
abnormal spleen morphology J:42508, J:58981
abnormal spleen red pulp morphology J:42508
absent axillary lymph nodes J:42508
absent brachial lymph nodes J:42508
absent cervical lymph nodes J:58981
absent follicular dendritic cells J:58981
absent inguinal lymph nodes J:42508
absent Peyer's patches J:42508
absent popliteal lymph nodes J:42508
absent spleen marginal zone J:58981
decreased spleen white pulp amount J:109621
increased lymphocyte cell number J:42508
Ltbtm1Krn/Ltbtm1Krn
C57BL/6-Ltbtm1Krn 		abnormal humoral immune response J:78229
abnormal mesenteric lymph node morphology J:78229
abnormal spleen morphology J:78229
absent cervical lymph nodes J:78229
absent peripheral lymph nodes J:78229
absent Peyer's patches J:78229
decreased IgG1 level J:78229
decreased IgG2a level J:78229
increased IgM level J:78229
increased susceptibility to induced morbidity/mortality J:78229
increased susceptibility to parasitic infection J:78229
spleen hyperplasia J:78229
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory