About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Kcnj6
potassium inwardly-rectifying channel, subfamily J, member 6
MGI:104781
74 phenotypes from 2 alleles in 9 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Kcnj6tm1Stf/Kcnj6tm1Stf
involves: 129S1/Sv * 129X1/SvJ
abnormal synaptic transmission J:77047
environmentally induced seizures J:38206
increased susceptibility to pharmacologically induced seizures J:38206
tonic-clonic seizures J:38206
Kcnj6tm1Stf/Kcnj6wv
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
abnormal cerebellar Purkinje cell layer J:38206
thin cerebellar granule layer J:38206
Kcnj6wv/Kcnj6+
B6CBA Aw-J/A-Kcnj6wv
abnormal male germ cell morphology J:23163
abnormal seminiferous tubule epithelium morphology J:23163
abnormal sperm motility J:23163
abnormal spermatid morphology J:23163
abnormal spermatogenesis J:23163
oligozoospermia J:23163
Kcnj6wv/Kcnj6+
B6CBACa Aw-J/A-Kcnj6wv/J
abnormal cerebellar Purkinje cell layer J:72069
abnormal Purkinje cell dendrite morphology J:72069
abnormal Purkinje cell morphology J:72069
delaminated Purkinje cell layer J:72069
Kcnj6wv/Kcnj6+
involves: C57BL/6 * CBA/CaGnLe
abnormal cerebellar granule layer morphology J:46842
abnormal cerebellar Purkinje cell layer J:46842
abnormal cerebellum morphology J:18348
small cerebellum J:46842
Kcnj6wv/Kcnj6+
involves: C57BL/6J
abnormal cell migration J:16025
abnormal cerebellar molecular layer J:16025
abnormal cerebellum morphology J:16025
abnormal cerebellum vermis morphology J:16025
abnormal locomotor behavior J:38206
abnormal substantia nigra pars compacta morphology J:38206
increased apoptosis J:16025
male infertility J:38206
Kcnj6wv/Kcnj6wv
B6CBA Aw-J/A-Kcnj6wv
abnormal ion homeostasis J:106298
abnormal male germ cell morphology J:23163
abnormal seminiferous tubule epithelium morphology J:23163
abnormal seminiferous tubule morphology J:23163
abnormal Sertoli cell morphology J:23163
abnormal sperm motility J:23163
abnormal spermatid morphology J:106298
abnormal spermatogenesis J:23163
globozoospermia J:23163
oligozoospermia J:23163
Kcnj6wv/Kcnj6wv
B6CBACa Aw-J/A-Kcnj6wv/J
abnormal cerebellar cortex morphology J:72069
abnormal cerebellar lobule formation J:72069
abnormal cerebellar Purkinje cell layer J:72069
abnormal locomotor activation J:6717
abnormal nervous system morphology J:6717
abnormal Purkinje cell dendrite morphology J:72069
abnormal substantia nigra pars compacta morphology J:6717
ataxia J:72069
decreased body weight J:72069
decreased dopamine level J:6717
decreased dopaminergic neuron number J:6717
ectopic Purkinje cell J:72069
normal homeostasis/metabolism phenotype J:29151
Kcnj6wv/Kcnj6wv
C57BL/6J-Kcnj6wv
abnormal cerebellar granule cell morphology J:15542
abnormal cerebellar granule layer morphology J:30520
abnormal cerebellar molecular layer J:30520
abnormal cerebellar Purkinje cell layer J:30520
abnormal cerebellum development J:30520
abnormal cerebellum external granule cell layer morphology J:30520
abnormal gait J:30520
abnormal maternal nurturing J:30520
abnormal motor capabilities/coordination/movement J:13422
abnormal motor coordination/ balance J:30520
absent cerebellar lobules J:30520
absent cerebellum fissure J:30520
decreased body size J:30520
decreased body weight J:30520
decreased food intake J:30520
impaired righting response J:30520
increased Purkinje cell number J:30520
induced hyperactivity J:30520
lethality at weaning, incomplete penetrance J:30520
premature death J:13422, J:30520
reduced female fertility J:30520
reduced male fertility J:30520
small cerebellum J:30520
tonic-clonic seizures J:30520
tremors J:30520
weaving J:30520
Kcnj6wv/Kcnj6wv
involves: C57BL/6
abnormal cerebellar granule cell morphology J:35792
abnormal CNS synaptic transmission J:35792
abnormal cochlear VIII nucleus morphology J:121314
abnormal neurotransmitter level J:6875
abnormal synaptic glutamate release J:6875
decreased Purkinje cell number J:121314
small cerebellum J:6875
Kcnj6wv/Kcnj6wv
involves: C57BL/6 * CBA/CaGnLe
abnormal cerebellar granule layer morphology J:46842
abnormal cerebellar molecular layer J:46842
abnormal cerebellum external granule cell layer morphology J:46842
abnormal epididymis morphology J:18348
abnormal noradrenaline level J:164122
abnormal seminiferous tubule morphology J:18348
abnormal testis morphology J:18348
ataxia J:18348, J:46842
azoospermia J:18348
hypotonia J:18348
impaired righting response J:18348
increased apoptosis J:46842
male infertility J:18348
retropulsion J:18348
seminiferous tubule degeneration J:18348, J:46842
small cerebellum J:18348, J:46842, J:164122
tremors J:18348
Kcnj6wv/Kcnj6wv
involves: C57BL/6J
abnormal cell migration J:16025
abnormal cerebellar cortex morphology J:5315
abnormal cerebellar granule layer morphology J:5315, J:16025
abnormal cerebellar molecular layer J:16025
abnormal cerebellar Purkinje cell layer J:5315
abnormal cerebellum morphology J:5315, J:16025
abnormal cerebellum vermis morphology J:16025
abnormal Purkinje cell morphology J:5315
increased apoptosis J:16025
Kcnj6wv/Kcnj6wv
involves: C57BL/6J * CBA
abnormal hippocampal mossy fiber morphology J:30108
abnormal hippocampus pyramidal cell layer J:30108
ectopic hippocampus pyramidal cells J:30108

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/14/2017
MGI 6.11
The Jackson Laboratory