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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cdkn2a
cyclin dependent kinase inhibitor 2A
MGI:104738
77 phenotypes from 17 alleles in 19 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cdkn2aem1Cjs/Cdkn2aem1Cjs
B6.Cg-Cdkn2aem1Cjs 		increased acute lymphoblastic leukemia incidence J:244260
increased testis weight J:244260
normal reproductive system phenotype J:244260
normal vision/eye phenotype J:244260
Cdkn2aem2Cjs/Cdkn2aem2Cjs
C57BL/6-Cdkn2aem2Cjs 		abnormal spermatocyte morphology J:244260
binocular blindness J:244260
normal neoplasm J:244260
oligozoospermia J:244260
persistent hyperplastic primary vitreous J:244260
retina detachment J:244260
Cdkn2aPctr1-DBA/2N/?
involves: BALB/cAnPt * DBA/2N 		decreased tumor incidence J:16958
Cdkn2atm1(GFP)Cjs/Cdkn2atm1(GFP)Cjs
involves: 129S1/Sv * C57BL/6 		increased gastrointestinal stromal tumor incidence J:87339
increased hemangiosarcoma incidence J:87339
increased histiocytic sarcoma incidence J:87339
increased incidence of tumors by ionizing radiation induction J:87339
increased lymphoma incidence J:87339
increased sarcoma incidence J:87339
increased tumor incidence J:87339
Cdkn2atm1.1Brn/Cdkn2atm1.1Brn
involves: 129P2/OlaHsd * FVB/N 		decreased incidence of tumors by chemical induction J:125189
normal neoplasm J:71393
Cdkn2atm1.1Gsu/Cdkn2atm1.1Gsu
Tg(Pdx1-cre)6Tuv/0
involves: 129S4/SvJaeSor * C57BL/6J * FVB/N 		normal neoplasm J:198619
Cdkn2atm1a(EUCOMM)Wtsi/Cdkn2atm1a(EUCOMM)Wtsi
C57BL/6N-Cdkn2atm1a(EUCOMM)Wtsi/Wtsi 		abnormal lens morphology J:175295
cataract J:175295
Cdkn2atm1Cjs/Cdkn2a+
involves: 129X1/SvJ * C57BL/6 * NIH/OlaHsd 		increased carcinoma incidence J:93298
increased incidence of tumors by chemical induction J:93298
increased papilloma incidence J:93298
Cdkn2atm1Cjs/Cdkn2atm1Cjs
involves: 129X1/SvJ 		blindness J:147752
decreased testis weight J:147752
oligozoospermia J:147752
testicular atrophy J:147752
Cdkn2atm1Cjs/Cdkn2atm1Cjs
involves: 129X1/SvJ * C57BL/6 		abnormal cell physiology J:44427
abnormal lens capsule morphology J:75215
abnormal lens morphology J:75215
abnormal retina ganglion layer morphology J:75215
abnormal retina inner nuclear layer morphology J:75215
abnormal retina morphology J:75215
abnormal retina photoreceptor morphology J:75215
abnormal spermatocyte morphology J:244260
binocular blindness J:244260
decreased testis weight J:244260
increased acute lymphoblastic leukemia incidence J:244260
increased carcinoma incidence J:44427
increased fibroblast proliferation J:44427
increased fibrohistocytoma incidence J:44427
increased fibrosarcoma incidence J:44427
increased incidence of tumors by chemical induction J:44427
increased incidence of tumors by ionizing radiation induction J:44427
increased lymphoma incidence J:44427
increased T cell derived lymphoma incidence J:44427
increased tumor incidence J:44427
microphthalmia J:75215
oligozoospermia J:244260
persistent hyperplastic primary vitreous J:75215, J:149526
primary vitreous hyperplasia J:101016
retina detachment J:75215, J:244260
retina fold J:75215
normal vision/eye phenotype J:149526
Cdkn2atm1Cjs/Cdkn2atm1Cjs
involves: 129X1/SvJ * C57BL/6 * NIH/OlaHsd 		increased carcinoma incidence J:93298
increased incidence of tumors by chemical induction J:93298
increased metastatic potential J:93298
increased papilloma incidence J:93298
increased squamous cell carcinoma incidence J:93298
increased tumor growth/size J:93298
Cdkn2atm1Nesh/Cdkn2atm1Nesh
involves: 129S6/SvEvTac * FVB/N 		abnormal cell physiology J:88365
hindlimb paralysis J:88365
increased incidence of tumors by chemical induction J:88365
increased lung carcinoma incidence J:88365
increased osteosarcoma incidence J:88365
increased sarcoma incidence J:88365
increased small lymphocytic lymphoma incidence J:88365
increased tumor incidence J:88365
seizures J:88365
Cdkn2atm1Rdp/Cdkn2atm1Rdp
FVB.Cg-Cdkn2atm1Rdp 		abnormal lens development J:110215
abnormal posterior eye segment morphology J:110215
abnormal retina neuronal layer morphology J:110215
abnormal retina photoreceptor morphology J:110215
cataract J:110215
microphthalmia J:110215
persistent hyperplastic primary vitreous J:110215
retina fold J:110215
Cdkn2atm1Rdp/Cdkn2atm1Rdp
involves: 129/Sv * C57BL/6 * C57BL/6J * SJL 		abnormal cell physiology J:72780
abnormal keratinocyte physiology J:72780
abnormal skin physiology J:72780
delayed cellular replicative senescence J:72780
increased squamous cell carcinoma incidence J:72780
Cdkn2atm1Rdp/Cdkn2atm1Rdp
involves: 129/Sv * C57BL/6 * SJL 		abnormal cell cycle J:53805
abnormal spleen morphology J:53805
abnormal spleen red pulp morphology J:53805
extramedullary hematopoiesis J:53805
increased B cell derived lymphoma incidence J:53805
increased cutaneous melanoma incidence J:98545
increased fibroblast proliferation J:53805
increased fibrosarcoma incidence J:53805
increased hemangiosarcoma incidence J:53805
increased sarcoma incidence J:53805
increased spleen white pulp amount J:53805
increased tumor incidence J:53805
Cdkn2atm1Rdp/Cdkn2atm1Rdp
involves: 129/Sv * C57BL/6J * FVB/N * SJL 		abnormal cell physiology J:88365
decreased tumor-free survival time J:88365
increased lymphoma incidence J:88365
increased sarcoma incidence J:88365
increased tumor incidence J:88365
Cdkn2atm1Rdp/Cdkn2atm1Rdp
involves: 129/Sv * C57BL/6J * SJL 		increased brain tumor incidence J:163931
Cdkn2atm1Sxs/Cdkn2atm1Sxs
involves: 129/Sv * C57BL/6 		abnormal eye morphology J:149526
abnormal tumor incidence J:149526
primary vitreous hyperplasia J:149526
Cdkn2atm2.1Brn/Cdkn2atm2.1Brn
involves: 129P2/OlaHsd * FVB/N 		increased carcinoma incidence J:71393
increased incidence of tumors by chemical induction J:71393
increased lymphoma incidence J:71393
increased melanoma incidence J:71393
increased metastatic potential J:71393
increased sarcoma incidence J:71393
increased tumor incidence J:71393
Cdkn2atm2.1Rdp/Cdkn2a+
involves: 129S6/SvEvTac * FVB/N 		increased tumor incidence J:71394
Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp
involves: 129S6/SvEvTac * FVB/N 		increased CD4-positive, alpha-beta T cell number J:71394
increased CD8-positive, alpha-beta T cell number J:71394
increased double-positive T cell number J:71394
increased incidence of tumors by chemical induction J:71394, J:88365
increased lymphoma incidence J:88365
increased osteosarcoma incidence J:88365
increased sarcoma incidence J:88365
increased small lymphocytic lymphoma incidence J:88365
increased splenocyte proliferation J:71394
increased thymus weight J:71394
increased tumor incidence J:71394, J:88365
thymus hyperplasia J:71394
Cdkn2atm3(cre)Cjs/Cdkn2a+
involves: 129S1/Sv * C57BL/6 		male infertility J:147752
Cdkn2atm3(cre)Cjs/Cdkn2atm4Cjs
involves: 129S1/Sv * C57BL/6 		abnormal lens morphology J:147752
abnormal retina morphology J:147752
blindness J:147752
microphthalmia J:147752
retina fold J:147752
Cdkn2atm4Cjs/Cdkn2atm4Cjs
involves: 129S1/Sv * C57BL/6 		normal neoplasm J:147752
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Tg(Pdx1-cre)89.1Dam/0
involves: C57BL/6 * CBA * FVB/N 		normal neoplasm J:87196
Tg(TTR-p19Cdkn2a)2Tvd/0
involves: C57BL/6J * DBA/2J 		increased circulating glucose level J:94077
polydipsia J:94077
polyuria J:94077
reduced female fertility J:94077
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory