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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Cnr1
cannabinoid receptor 1 (brain)
MGI:104615
80 phenotypes from 12 alleles in 19 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Cnr1tm1.1(KOMP)Vlcg/Cnr1tm1.1(KOMP)Vlcg
C57BL/6N-Cnr1tm1.1(KOMP)Vlcg/Ucd
preweaning lethality, incomplete penetrance J:211773
Cnr1tm1.1Kpm/Cnr1tm1.1Kpm
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
abnormal cerebral cortex morphology J:208116
abnormal neuron physiology J:208116
abnormal synaptic plasticity J:208116
increased behavioral withdrawal response J:208116
increased chemically-elicited antinociception J:208116
increased physiological sensitivity to xenobiotic J:208116
Cnr1tm1.1Ltz/Cnr1+
involves: 129P2/OlaHsd * C57BL/6N
increased susceptibility to pharmacologically induced seizures J:89842
Cnr1tm1.1Ltz/Cnr1tm1.1Ltz
B6.129P2-Cnr1tm1.1Ltz
abnormal axon fasciculation J:171771
abnormal learning/memory/conditioning J:77936
abnormal nervous system development J:171771
abnormal nervous system morphology J:171771
abnormal paired-pulse facilitation J:77936
absent long term depression J:77936
normal behavior/neurological phenotype J:77936
decreased exploration in new environment J:77936
enhanced long term potentiation J:77936
normal nervous system phenotype J:171771
Cnr1tm1.1Ltz/Cnr1tm1.1Ltz
involves: 129P2/OlaHsd * C57BL/6N
increased sensitivity to xenobiotic induced morbidity/mortality J:89842
increased susceptibility to pharmacologically induced seizures J:89842
Cnr1tm1.1Pcn/Cnr1tm1.1Pcn
Tg(Phox2b-cre)1Jke/0
involves: 129 * C57BL/6J
abnormal gastrointestinal motility J:186542
normal behavior/neurological phenotype J:186542
normal growth/size/body region phenotype J:186542
normal homeostasis/metabolism phenotype J:186542
Cnr1tm1.2Ltz/Cnr1tm1.2Ltz
involves: 129P2/OlaHsd * C57BL/6NCrl
increased susceptibility to pharmacologically induced seizures J:122066
Cnr1tm1.2Ltz/Cnr1tm1.2Ltz
Neurod6tm1(cre)Kan/Neurod6+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl
abnormal axon fasciculation J:171771
abnormal impulsive behavior control J:179495
abnormal nervous system development J:171771
abnormal response to novel object J:179495
increased susceptibility to pharmacologically induced seizures J:122066
Cnr1tm1.2Ltz/Cnr1tm1.2Ltz
Tg(Camk2a-cre)2Gsc/0
involves: 129P2/OlaHsd * C57BL/6N
increased sensitivity to xenobiotic induced morbidity/mortality J:89842
increased susceptibility to neuronal excitotoxicity J:89842
increased susceptibility to pharmacologically induced seizures J:89842
Cnr1tm1.2Ltz/Cnr1tm1.2Ltz
Tg(Camk2a-cre)2Gsc/?
involves: 129P2/OlaHsd * C57BL/6NCrl * FVB/N
abnormal impulsive behavior control J:179495
abnormal response to novel object J:179495
increased susceptibility to pharmacologically induced seizures J:122066
Cnr1tm1.2Ltz/Cnr1tm1.2Ltz
Tg(dlx6a-cre)1Mekk/?
involves: 129P2/OlaHsd * C57BL/6NCrl * CD-1
abnormal inhibitory postsynaptic currents J:122066
normal behavior/neurological phenotype J:122066
Cnr1tm1.2Ltz/Cnr1tm1.2Ltz
Tg(dlx6a-cre)1Mekk/?
involves: 129P2/OlaHsd * CD-1
abnormal cerebral cortex morphology J:121856
Cnr1tm1Dgen/Cnr1tm1Dgen
involves: 129S1/Sv * 129X1/SvJ
impaired behavioral response to xenobiotic J:144774
Cnr1tm1Dgen/Cnr1tm1Dgen
involves: 129S1/Sv * 129X1/SvJ * ICR
normal nervous system phenotype J:143885
reduced long term depression J:144773
Cnr1tm1Lex/Cnr1tm1Lex
involves: 129S5/SvEvBrd * C57BL/6J
decreased percent body fat/body weight J:185494
Cnr1tm1Map/Cnr1+
involves: 129S1/Sv * 129X1/SvJ * CD-1
increased cerebral infarction size J:109213
Cnr1tm1Map/Cnr1tm1Map
B6.129-Cnr1tm1Map
abnormal nervous system physiology J:156514
abnormal sweet taste sensitivity J:156514
Cnr1tm1Map/Cnr1tm1Map
involves: 129S1/Sv * 129X1/SvJ
abnormal bone mineral density J:105218
abnormal inhibitory postsynaptic currents J:109305
abnormal sperm motility J:123226
enhanced long term potentiation J:60079
increased bone mineral density J:105218
normal skeleton phenotype J:105218
Cnr1tm1Map/Cnr1tm1Map
involves: 129S1/Sv * 129X1/SvJ * CD-1
abnormal active avoidance behavior J:103942
abnormal depression-related behavior J:103942
abnormal neuronal precursor proliferation J:102006
abnormal response to novel object J:52188
abnormal social/conspecific interaction J:89722
anhedonia J:103942
decreased chemically-elicited antinociception J:52188
hyperactivity J:52188
impaired behavioral response to addictive substance J:52188
impaired behavioral response to morphine J:52188
impaired conditioned place preference behavior J:52188
increased aggression towards mice J:89722, J:103942
increased anxiety-related response J:89437, J:89722, J:103942
increased cerebral infarction size J:109213
increased circulating adrenocorticotropin level J:89722
increased exploration in new environment J:52188
increased physiological sensitivity to xenobiotic J:172874
increased sensitivity to induced morbidity/mortality J:109213
increased susceptibility to ischemic brain injury J:109213
increased susceptibility to neuronal excitotoxicity J:109213
Cnr1tm1Ojm/Cnr1tm1Ojm
involves: 129P2/OlaHsd * C57BL/6
abnormal excitatory postsynaptic potential J:93698
abnormal food intake J:93697
absent long term depression J:93698
decreased body weight J:93697
decreased circulating insulin level J:93697
decreased circulating leptin level J:93697
decreased susceptibility to diet-induced obesity J:93697
decreased total body fat amount J:93697
increased insulin sensitivity J:93697
weight loss J:93697
Cnr1tm1Zim/Cnr1tm1Zim
involves: 129 * C57BL/6J
catalepsy J:54995
decreased circulating progesterone level J:144423
decreased survivor rate J:54995
decreased vertical activity J:55294
early parturition J:144423
hypoactivity J:54995, J:55294
hypoalgesia J:54995
impaired behavioral response to addictive substance J:54995
increased chemical nociceptive threshold J:54995
increased circulating corticosterone level J:144423
increased circulating estradiol level J:144423
increased follicle stimulating hormone level J:144423
increased thermal nociceptive threshold J:54995
maternal effect J:144423
postnatal lethality, incomplete penetrance J:54995
premature death J:54995
Cnr1tm2.1Ltz/Cnr1tm2.1Ltz
B6.Cg-Cnr1tm2.1Ltz
no abnormal phenotype detected J:199647
Cnr1tm2Ltz/Cnr1tm2.1Ltz
Neurod6tm1(cre)Kan/Neurod6+
B6.Cg-Cnr1tm2Ltz/Cnr1tm2.1Ltz
abnormal cued conditioning behavior J:199647
normal behavior/neurological phenotype J:199647
decreased synaptic depression J:199647
increased sensitivity to xenobiotic induced morbidity/mortality J:199647
Cnr1tm2Ltz/Cnr1tm2Ltz
B6.Cg-Cnr1tm2Ltz
abnormal cued conditioning behavior J:199647
decreased synaptic depression J:199647
impaired cued conditioning behavior J:199647
increased anxiety-related response J:199647
increased sensitivity to xenobiotic induced morbidity/mortality J:199647
increased susceptibility to pharmacologically induced seizures J:199647

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory