Xrcc5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Xrcc5
X-ray repair complementing defective repair in Chinese hamster cells 5
MGI:104517

39 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Xrcc5^m1Btlr/Xrcc5^m1Btlr C57BL/6J-Xrcc5^m1Btlr	abnormal B cell differentiation	J:274736
	abnormal CD8-positive, alpha-beta T cell differentiation	J:274736
	abnormal T cell differentiation	J:274736
	decreased B-2 B cell number	J:274736
	decreased CD4-positive, alpha-beta T cell number	J:274736
	decreased CD8-positive, alpha-beta T cell number	J:274736
	decreased CD8-positive, naive alpha-beta T cell number	J:274736
	decreased T cell number	J:274736
	increased B-1a cell number	J:274736
	increased B-1b cell number	J:274736
	increased CD4-positive, alpha-beta T cell number	J:274736
	increased dendritic cell number	J:274736
	increased effector memory CD4-positive, alpha-beta T cell number	J:274736
	increased effector memory CD8-positive, alpha-beta T cell number	J:274736
	increased neutrophil cell number	J:274736
Xrcc5^tm1Dbr/Xrcc5⁺ involves: 129S6/SvEvTac * C57BL/6	chromosome breakage	J:80467
Xrcc5^tm1Dbr/Xrcc5^tm1Dbr involves: 129S1/Sv * C57BL/6	abnormal B cell differentiation	J:34834
	abnormal retina morphology	J:86825
	absent T cells	J:34834
	arrested B cell differentiation	J:34834
	arrested T cell differentiation	J:34834
	increased double-negative T cell number	J:34834
	increased retina apoptosis	J:86825
	lymph node hypoplasia	J:34834
	thymus hypoplasia	J:34834
Xrcc5^tm1Dbr/Xrcc5^tm1Dbr involves: 129S6/SvEvTac * C57BL/6	chromosome breakage	J:80467
	normal mortality/aging	J:80467
	prenatal lethality, incomplete penetrance	J:80467
Xrcc5^tm1Dbr/Xrcc5^tm1Dbr Not Specified	increased neuron apoptosis	J:110848
Xrcc5^tm1Nus/Xrcc5^tm1Nus involves: 129S1/Sv * 129X1/SvJ	abnormal bone marrow cell morphology/development	J:108657
	abnormal class switch recombination	J:120658
	abnormal double-strand DNA break repair	J:108657
	abnormal humoral immune response	J:120658
	abnormal maternal nurturing	J:81484
	decreased body size	J:81484
	decreased litter size	J:81484
	fetal growth retardation	J:81484
	increased cellular sensitivity to ionizing radiation	J:108657
	postnatal lethality, incomplete penetrance	J:81484
	proportional dwarf	J:81484
	spleen hypoplasia	J:108657
	thymus hypoplasia	J:108657

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23