Tnfsf4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tnfsf4
tumor necrosis factor (ligand) superfamily, member 4
MGI:104511

33 phenotypes from 11 alleles in 13 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tg(Actb-Tnfsf4)1Nish/0 B6.D2-Tg(Actb-Tnfsf4)1Nish	abnormal cytokine secretion	J:80214
	increased susceptibility to type IV hypersensitivity reaction	J:80214
	increased T cell proliferation	J:80214
Tg(Lck-Tnfsf4)1Nish/0 B6.Cg-Tg(Lck-Tnfsf4)1Nish	abnormal CD4-positive, alpha-beta T cell physiology	J:194882
	abnormal cytokine secretion	J:80214
	abnormal lung morphology	J:194882
	abnormal pulmonary artery morphology	J:194882
	abnormal T cell subpopulation ratio	J:194882
	heart right ventricle hypertrophy	J:194882
	increased CD4-positive, alpha-beta T cell number	J:194882
	increased interleukin-13 secretion	J:194882
	increased regulatory T cell number	J:194882
	increased right ventricle systolic pressure	J:194882
	increased susceptibility to type IV hypersensitivity reaction	J:80214
	increased T cell proliferation	J:80214
	increased vasoconstriction	J:194882
	lung inflammation	J:194882
Tg(Lck-Tnfsf4)1Nish/0 C.Cg-Tg(Lck-Tnfsf4)1Nish	abnormal CD4-positive, alpha-beta T cell physiology	J:194882
	normal cardiovascular system phenotype	J:194882
	increased CD4-positive, alpha-beta T cell number	J:194882
	increased interleukin-13 secretion	J:194882
	increased regulatory T cell number	J:194882
	normal respiratory system phenotype	J:194882
Tg(Mt1-Tnfsf4)1Pgn/? C57BL/6J-Tg(Mt1-Tnfsf4)1Pgn	normal homeostasis/metabolism phenotype	J:97460
Tg(Mt1-Tnfsf4)1Pgn/? C57BL/6J-Tg(Mt1-Tnfsf4)1Pgn	increased susceptibility to atherosclerosis	J:97460
Tg(Mt1-Tnfsf4)2Pgn/? C57BL/6J-Tg(Mt1-Tnfsf4)2Pgn	normal homeostasis/metabolism phenotype	J:97460
Tg(Mt1-Tnfsf4)2Pgn/? C57BL/6J-Tg(Mt1-Tnfsf4)2Pgn	increased susceptibility to atherosclerosis	J:97460
Tnfsf4^Ath1-BALB/cJ/? involves: BALB/cJ * C57BL/6J	decreased susceptibility to atherosclerosis	J:8735
Tnfsf4^Ath1-BALB/cJ/? involves: BALB/cJ * C57BL/6J	increased circulating HDL cholesterol level	J:8735
Tnfsf4^Ath1-C3H/HeJ/? involves: C3H/HeJ * C57BL/6J	increased circulating HDL cholesterol level	J:9135
Tnfsf4^{Ath1-C57BL/6J}/? involves: BALB/cJ * C57BL/6J	abnormal cardiovascular system morphology	J:8735
Tnfsf4^{Ath1-C57BL/6J}/? involves: BALB/cJ * C57BL/6J	abnormal lipid homeostasis	J:8735
Tnfsf4^{Ath1-C57BL/6J}/? involves: C3H/HeJ * C57BL/6J	decreased circulating HDL cholesterol level	J:8735, J:9135
Tnfsf4^{Ath1-C57BL/6J}/? involves: C3H/HeJ * C57BL/6J	increased susceptibility to atherosclerosis	J:8735
Tnfsf4^{Ath1-PERA/EiJ}/Tnfsf4^{Ath1-C57BL/6J} B6.PERA-Tnfsf4^{Ath1-PERA/EiJ}/Pgn	increased circulating HDL cholesterol level	J:79722
Tnfsf4^{Ath1-PERA/EiJ}/Tnfsf4^{Ath1-PERA/EiJ} B6.PERA-Tnfsf4^{Ath1-PERA/EiJ}/Pgn	abnormal blood vessel morphology	J:79722
	increased circulating HDL cholesterol level	J:79722
Tnfsf4^{Ath1-SPRET/EiJ}/Tnfsf4^{Ath1-SPRET/EiJ} involves: C57BL/6J * SPRET/EiJ	decreased susceptibility to atherosclerosis	J:79722
Tnfsf4^tm1Shr/Tnfsf4^tm1Shr C.129S4-Tnfsf4^tm1Shr	abnormal cytokine secretion	J:59203
Tnfsf4^tm1Shr/Tnfsf4^tm1Shr C.129S4-Tnfsf4^tm1Shr	abnormal dendritic cell antigen presentation	J:59203
Tnfsf4^tm1Shr/Tnfsf4^tm1Shr involves: 129S4/SvJae	abnormal cell-mediated immunity	J:59203
	abnormal dendritic cell antigen presentation	J:59203
	decreased interferon-gamma secretion	J:59203
	decreased interleukin-2 secretion	J:59203
	decreased interleukin-4 secretion	J:59203
	decreased susceptibility to type IV hypersensitivity reaction	J:59203
	decreased T cell proliferation	J:59203
	normal immune system phenotype	J:59203
Tnfsf4^tm1Shr/Tnfsf4^tm1Shr NOD.129S4-Tnfsf4^tm1Shr	decreased susceptibility to autoimmune diabetes	J:86926
Tnfsf4^tm1Sug/Tnfsf4^tm1Sug B6.129S4-Tnfsf4^tm1Sug	abnormal cytokine secretion	J:80214
	decreased susceptibility to type IV hypersensitivity reaction	J:80214
	decreased T cell proliferation	J:80214

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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