Ptger4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ptger4
prostaglandin E receptor 4 (subtype EP4)
MGI:104311

58 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ptger4^tm1.1Matb/Ptger4^tm1.1Matb involves: 129S6/SvEvTac * C57BL/6	no abnormal phenotype detected	J:92301
Ptger4^tm1.1Matb/Ptger4^tm1.1Matb Tg(Myh6-cre)2182Mds/0 involves: 129S6/SvEvTac * FVB/N	abnormal cardiac muscle tissue morphology	J:158439
	abnormal heart echocardiography feature	J:158439
	abnormal myocardial fiber morphology	J:158439
	cardiac hypertrophy	J:158439
	cardiac interstitial fibrosis	J:158439
	decreased cardiac muscle contractility	J:158439
	decreased heart left ventricle posterior wall thickness	J:158439
	dilated cardiomyopathy	J:158439
	dilated heart left ventricle	J:158439
	heart inflammation	J:158439
	increased heart weight	J:158439
Ptger4^tm1.2Matb/Ptger4⁺ B6.129S6-Ptger4^tm1.2Matb	abnormal calcium ion homeostasis	J:112753
Ptger4^tm1.2Matb/Ptger4^tm1.2Matb B6.129S6-Ptger4^tm1.2Matb	abnormal calcium ion homeostasis	J:112753
Ptger4^tm1.2Matb/Ptger4^tm1.2Matb involves: 129S6/SvEvTac * C57BL/6	patent ductus arteriosus	J:92301
	perinatal lethality	J:92301
Ptger4^tm1Bhk/Ptger4^tm1Bhk involves: 129P2/OlaHsd * 129S/SvEv	abnormal capillary morphology	J:44108
	abnormal lung morphology	J:44108
	decreased pulmonary vascular resistance	J:44108
	increased lung weight	J:44108
	left-to-right shunt	J:44108
	liver vascular congestion	J:44108
	lung hemorrhage	J:44108
	lymphangiectasis	J:44108
	macrovesicular hepatic steatosis	J:44108
	microvesicular hepatic steatosis	J:44108
	patent ductus arteriosus	J:44108
	postnatal lethality, complete penetrance	J:44108
	pulmonary alveolar hemorrhage	J:44108
	pulmonary edema	J:44108
	pulmonary vascular congestion	J:44108
Ptger4^tm1Bhk/Ptger4^tm1Bhk involves: 129P2/OlaHsd * C57BL/6 * DBA/2	abnormal circulating interleukin-6 level	J:78964
	abnormal circulating serum amyloid protein level	J:78964
	abnormal cytokine level	J:78964
	abnormal macrophage physiology	J:78964
	abnormal prostaglandin level	J:78964
	abnormal vascular regression	J:44108
	decreased susceptibility to induced arthritis	J:78964
	normal immune system phenotype	J:78964
	normal mortality/aging	J:44108
	rheumatoid arthritis	J:78964
Ptger4^tm1Matb/Ptger4^tm1Matb involves: 129S6/SvEvTac * C57BL/6	neonatal lethality	J:92301
	patent ductus arteriosus	J:92301
Ptger4^tm1Sna/Ptger4^tm1Sna involves: 129P2/OlaHsd * C57BL/6	abnormal Langerhans cell physiology	J:83725
	abnormal osteoclast differentiation	J:63070
	abnormal osteoclast physiology	J:63070
	abnormal pulmonary alveolus morphology	J:47618
	abnormal T cell activation	J:83725
	normal cardiovascular system phenotype	J:92865
	congestive heart failure	J:47618
	decreased interferon-gamma secretion	J:83725
	decreased survivor rate	J:47618
	decreased susceptibility to type IV hypersensitivity reaction	J:83725
	decreased T cell proliferation	J:83725
	dilated heart left ventricle	J:47618
	dilated pulmonary artery	J:47618
	normal homeostasis/metabolism phenotype	J:70534, J:92865
	normal immune system phenotype	J:83725, J:197334
	lethargy	J:47618
	pallor	J:47618
	patent ductus arteriosus	J:47618
	postnatal lethality	J:47618
	pulmonary vascular congestion	J:47618
Ptger4^tm1Sna/Ptger4^tm1Sna involves: 129P2/OlaHsd * C57BL/6Cr	decreased incidence of tumors by chemical induction	J:73944
	preneoplasia	J:73944

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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