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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tyro3
TYRO3 protein tyrosine kinase 3
MGI:104294
62 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
anx/anx
Tg(TYRO3)1Sapc/?
Tyro3m1/Tyro3m1
involves: C3HeB/FeJLe * C57BL/6J 		abnormal body weight J:241666
abnormal survival J:241666
anx/anx
Tg(Tyro3*-Gfp)1Sapc/?
Tyro3m1/Tyro3m1
involves: C3HeB/FeJLe * C57BL/6J 		abnormal head movements J:241666
cachexia J:241666
premature death J:241666
tremors J:241666
anx/anx
Tg(Tyro3-GFP)1Sapc/?
Tyro3m1/Tyro3m1
involves: C3HeB/FeJLe * C57BL/6J 		abnormal body weight J:241666
abnormal survival J:241666
anx/anx
Tyro3m1/Tyro3m1
involves: C3HeB/FeJLe * C57BL/6J 		abnormal hypothalamus morphology J:241666
abnormal platelet activation J:241666
abnormal platelet morphology J:241666
cachexia J:241666
Axltm1Grl/Axltm1Grl
Mertktm1Grl/Mertktm1Grl
Tyro3tm1Grl/Tyro3tm1Grl
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal B cell activation J:70420
abnormal blood vessel morphology J:54681
abnormal brain thrombosis J:70420
abnormal cerebellum morphology J:54681
abnormal cerebral cortex morphology J:54681
abnormal hippocampus morphology J:54681
abnormal macrophage physiology J:70420
abnormal professional antigen presenting cell physiology J:70420
abnormal prostate gland epithelium morphology J:54681
abnormal seminiferous tubule morphology J:54681
abnormal spermatogenesis J:54681
abnormal susceptibility to autoimmune disorder J:70420
abnormal T cell activation J:70420
abnormal thrombosis J:70420
abnormal uterus morphology J:142166
azoospermia J:54681
blindness J:54681
decreased Sertoli cell phagocytosis J:133455
enlarged lymph nodes J:70420
enlarged spleen J:54681, J:70420
enlarged uterus J:142166
increased anti-double stranded DNA antibody level J:70420
increased apoptosis J:54681
increased autoantibody level J:70420
increased B cell proliferation J:70420
increased brain apoptosis J:54681
increased circulating tumor necrosis factor level J:70420
increased granulosa cell apoptosis J:54681
increased lymphocyte cell number J:70420
increased splenocyte apoptosis J:54681
increased T cell proliferation J:70420
internal hemorrhage J:70420
joint inflammation J:70420
liver degeneration J:54681
male infertility J:54681
reduced female fertility J:54681, J:70420
retina cone cell degeneration J:54681
retina rod cell degeneration J:54681
skin lesions J:70420
small endometrial glands J:142166
small testis J:54681
vagina atresia J:142166
Axltm1Grl/Axltm1Grl
Tyro3tm1Grl/Tyro3tm1Grl
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal forebrain development J:141251
abnormal forebrain morphology J:141251
abnormal neuronal migration J:141251
abnormal spermatogenesis J:54681
delayed estrous cycle J:141251
delayed sexual maturation J:141251
increased anti-double stranded DNA antibody level J:70420
increased apoptosis J:141251
increased neuron apoptosis J:141251
prolonged estrous cycle J:141251
prolonged proestrus J:141251
normal reproductive system phenotype J:133455
short diestrus J:141251
small testis J:54681
Mertktm1Grl/Mertktm1Grl
Tyro3tm1Grl/Tyro3tm1Grl
involves: 129S1/Sv * 129X1/SvJ 		abnormal spermatogenesis J:54681
decreased Sertoli cell phagocytosis J:133455
oligozoospermia J:54681
small testis J:54681
vagina atresia J:142166
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory