Hsd11b1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
MGI:103562

22 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apoe^tm1Unc/Apoe^tm1Unc Hsd11b1^tm1Lex/Hsd11b1^tm1Lex B6.129-Hsd11b1^tm1Lex Apoe^tm1Unc	abnormal bone marrow cell physiology	J:199430
	abnormal cytokine secretion	J:199430
	abnormal macrophage derived foam cell morphology	J:199430
	normal behavior/neurological phenotype	J:199430
	normal cardiovascular system phenotype	J:199430
	decreased cholesterol level	J:199430
	decreased macrophage cell number	J:199430
	decreased susceptibility to atherosclerosis	J:199430
	decreased tumor necrosis factor secretion	J:199430
	normal growth/size/body region phenotype	J:199430
	hyperlipidemia	J:199430
	normal immune system phenotype	J:199430
H6pd^tm1Pmst/H6pd^tm1Pmst Hsd11b1^tm1.1Ggla/Hsd11b1^tm1.1Ggla involves: 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal skeletal muscle fiber morphology	J:189132
	centrally nucleated skeletal muscle fibers	J:189132
	decreased body weight	J:189132
	decreased circulating glucose level	J:189132
	decreased lean body mass	J:189132
	decreased quadriceps weight	J:189132
	decreased tibialis anterior weight	J:189132
	enlarged adrenal glands	J:189132
	increased skeletal muscle glycogen level	J:189132
	skeletal muscle atrophy	J:189132

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23