Atp6v0a1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Atp6v0a1
ATPase, H+ transporting, lysosomal V0 subunit A1
MGI:103286

27 phenotypes from 4 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Atp6v0a1^em1Hisa/Atp6v0a1^em1Hisa involves: ICR	embryonic lethality between implantation and placentation, complete penetrance	J:305201
Atp6v0a1^em2Hisa/Atp6v0a1^em2Hisa involves: ICR	abnormal cerebellar molecular layer	J:305201
	abnormal cerebral cortex pyramidal cell morphology	J:305201
	abnormal dentate gyrus morphology	J:305201
	abnormal excitatory synapse morphology	J:305201
	abnormal hippocampus CA3 region morphology	J:305201
	abnormal lysosome morphology	J:305201
	abnormal miniature excitatory postsynaptic currents	J:305201
	abnormal miniature inhibitory postsynaptic currents	J:305201
	abnormal synaptic vesicle morphology	J:305201
	absent gastric milk in neonates	J:305201
	ataxia	J:305201
	cleft palate	J:305201
	decreased body weight	J:305201
	decreased brain size	J:305201
	decreased cerebral cortex pyramidal cell number	J:305201
	decreased CNS synapse formation	J:305201
	impaired autophagy	J:305201
	impaired righting response	J:305201
	increased neuron apoptosis	J:305201
	postnatal lethality, complete penetrance	J:305201
Atp6v0a1^em3Hisa/Atp6v0a1^em3Hisa involves: ICR	embryonic lethality between implantation and placentation, complete penetrance	J:305201
Atp6v0a1^{tm1b(EUCOMM)Hmgu}/Atp6v0a1⁺ C57BL/6N-Atp6v0a1^{tm1b(EUCOMM)Hmgu}/Tcp	decreased total body fat amount	J:211773
	increased bone mineral content	J:211773
	increased circulating potassium level	J:211773
Atp6v0a1^{tm1b(EUCOMM)Hmgu}/Atp6v0a1^{tm1b(EUCOMM)Hmgu} C57BL/6N-Atp6v0a1^{tm1b(EUCOMM)Hmgu}/Tcp	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23