87 phenotypes from 22 alleles in 32 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Scn8a4J/Scn8a4J C57BL/6J-Scn8a4J/J	decreased body size	J:78134
	hindlimb paralysis	J:78134
	premature death	J:78134, J:90095
Scn8a5J/Scn8a5J C57BL/6J-Scn8a5J/J	abnormal brain morphology	J:78134
	decreased cerebellar granule cell number	J:78134
	enlarged brain ventricles	J:78134
	hindlimb paralysis	J:78134, J:90095
	hydrocephaly	J:78134
	postnatal lethality, complete penetrance	J:78134, J:90095
Scn8a6J/Scn8a6J C57BL/6J-Scn8a6J/J	abnormal gait	J:78134
	decreased body weight	J:78134
	hindlimb paralysis	J:90095
	muscular atrophy	J:90095
	normal nervous system phenotype	J:90095
	premature death	J:90095
Scn8a7J/Scn8a7J involves: BALB/cByJ * C57BL/6J	abnormal cerebellum external granule cell layer morphology	J:87349
	abnormal posture	J:87349
	abnormal ventral spinal root morphology	J:87349
	ataxia	J:87349
	decreased skeletal muscle fiber size	J:87349
	head tossing	J:87349
	limb grasping	J:87349
	myoclonus	J:87349
	myopathy	J:87349
	peripheral nervous system degeneration	J:87349
Scn8a8J/Scn8a+ involves: C3HeB/FeJ * C57BL/6J	abnormal spike wave discharge	J:147199
Scn8a8J/Scn8a8J involves: C3HeB/FeJ * C57BL/6J	abnormal gait	J:147199
	abnormal locomotor behavior	J:147199
	abnormal spike wave discharge	J:147199
	decreased body size	J:147199
	postnatal lethality	J:147199
	premature death	J:147199
Scn8a9J/Scn8a+ B6J.C-Scn8a9J/Mm	decreased locomotor activity	J:230867
Scn8a9J/Scn8a9J B6J.C-Scn8a9J/Mm	abnormal gait	J:230867
	abnormal motor capabilities/coordination/movement	J:230867
	abnormal neuron physiology	J:230867
	ataxia	J:230867
	decreased body weight	J:230867
	decreased grip strength	J:230867
	decreased nerve conduction velocity	J:230867
	dystonia	J:230867
	muscle weakness	J:230867
	premature death	J:230867
	tremors	J:230867
Scn8a9J/Scn8a9J BALB/cJ-Scn8a9J/GrsrJ	abnormal motor coordination/balance	J:220447
	premature death	J:220447
	tremors	J:220447
Scn8aClth/Scn8a+ involves: BALB/c	abnormal pinna reflex	J:250208
	absent pinna reflex	J:250208
	normal hearing/vestibular/ear phenotype	J:250208
	increased or absent threshold for auditory brainstem response	J:250208
Scn8aClth/Scn8a+ involves: BALB/cAnN * C3H/HeH	abnormal behavior	J:155726
	abnormal pilomotor reflex	J:155726
	abnormal pinna reflex	J:155726
	absent pinna reflex	J:155726
	decreased body weight	J:155726
	decreased startle reflex	J:155726
	normal hearing/vestibular/ear phenotype	J:155726
	hunched posture	J:155726
	impaired hearing	J:155726
	increased or absent threshold for auditory brainstem response	J:155726
	tremors	J:155726
Scn8aClth/Scn8aClth involves: BALB/c	decreased startle reflex	J:250208
	normal hearing/vestibular/ear phenotype	J:250208
	increased or absent threshold for auditory brainstem response	J:250208
Scn8aClth/Scn8aClth involves: BALB/cAnN * C3H/HeH	abnormal auditory brainstem response waveform shape	J:155726
	abnormal behavior	J:155726
	abnormal pilomotor reflex	J:155726
	abnormal reflex	J:155726
	decreased body weight	J:155726
	decreased Purkinje cell number	J:155726
	decreased startle reflex	J:155726
	enhanced behavioral response to anesthetic	J:155726
	normal hearing/vestibular/ear phenotype	J:155726
	hunched posture	J:155726
	impaired coordination	J:155726
	impaired hearing	J:155726
	increased anxiety-related response	J:155726
	increased or absent threshold for auditory brainstem response	J:155726
	normal mortality/aging	J:155726
	small cerebellum	J:155726
	tremors	J:155726
Scn8admu/Scn8admu involves: C3H * C57BL/6	abnormal atrium endocardium morphology	J:71615
	abnormal heart septum morphology	J:71615
	abnormal heart ventricle morphology	J:71615
	decreased body weight	J:71615
	dystrophic muscle	J:71615
	hindlimb paralysis	J:71615
	muscle degeneration	J:71615
	myocardial fiber degeneration	J:71615
	normal nervous system phenotype	J:71615
	premature death	J:71615
	respiratory distress	J:71615
	skeletal muscle necrosis	J:71615
Scn8admu/Scn8admu involves: C3H * C57BL/6 * C57BL/6J	abnormal eye electrophysiology	J:98511
Scn8admu/Scn8admu involves: C3H * C57BL/6 * DBA/2J	abnormal eye electrophysiology	J:98511
	normal vision/eye phenotype	J:98511
Scn8admu/Scn8amed involves: C3H * C3HeB/Fe * C57BL/6	abnormal voluntary movement	J:71615
	dystrophic muscle	J:71615
	hindlimb paralysis	J:71615
	postnatal lethality	J:71615
Scn8aem1(IMPC)Bay/Scn8a+ C57BL/6N-Scn8aem1(IMPC)Bay/BayMmucd	increased spleen weight	J:211773
Scn8aem1(IMPC)Bay/Scn8aem1(IMPC)Bay C57BL/6N-Scn8aem1(IMPC)Bay/BayMmucd	preweaning lethality, incomplete penetrance	J:211773
Scn8aem1Mm/Scn8a+ involves: C57BL/6J * SJL	abnormal behavior	J:207931
	premature death	J:207931
	seizures	J:207931
Scn8aM1Btlr/Scn8a+ C57BL/6J-Scn8aM1Btlr	abnormal gait	J:139714
	tremors	J:139714
Scn8aM1Btlr/Scn8aM1Btlr C57BL/6J-Scn8aM1Btlr	abnormal gait	J:139714
	tremors	J:139714
Scn8am2Btlr/Scn8am2Btlr C57BL/6J-Scn8am2Btlr	hindlimb paralysis	J:203623
Scn8am3Btlr/Scn8am3Btlr C57BL/6J-Scn8am3Btlr	ataxia	J:215819
	decreased body weight	J:215819
	tremors	J:215819
Scn8am10J/Scn8a+ FVB/NJ-Scn8am10J/GrsrCx	decreased nerve conduction velocity	J:240096
Scn8am10J/Scn8am10J FVB/NJ-Scn8am10J/GrsrCx	ataxia	J:199990
	decreased body size	J:199990
	paralysis	J:199990
	postnatal lethality, complete penetrance	J:199990
	tremors	J:199990
Scn8am11J/Scn8am11J B6.Cg-Scn8am11J/GrsrJ	ataxia	J:231578
	decreased body size	J:231578
	hindlimb paralysis	J:231578
	impaired muscle relaxation	J:231578
	paralysis	J:231578
	postnatal lethality, complete penetrance	J:231578
Scn8amed-J/Scn8amed-J involves: STOCK Krt71Ca	abnormal gait	J:141236
	ataxia	J:141236
	dystonia	J:141236
	normal mortality/aging	J:141236
	tremors	J:141236
Scn8amed-jo2J/Scn8amed-jo2J B6(129S7)-Scn8amed-jo2J/J	abnormal gait	J:92160
	axon degeneration	J:92160
	cervical vertebrae degeneration	J:92160
	increased or absent threshold for auditory brainstem response	J:92160
	oligozoospermia	J:92160
	postnatal lethality, incomplete penetrance	J:92160
	Purkinje cell degeneration	J:92160
	tremors	J:92160
Scn8amed-jo/Scn8a+ B6.D2-Scn8amed-jo/J	abnormal spike wave discharge	J:147199
	decreased susceptibility to pharmacologically induced seizures	J:129998, J:170734
Scn8amed-jo/Scn8amed-jo DBA/2WyDi-Scn8amed-jo	abnormal nervous system electrophysiology	J:14894
	impaired limb coordination	J:15056
	normal muscle phenotype	J:24907
	normal nervous system phenotype	J:24907
	Purkinje cell degeneration	J:14894
	tremors	J:15056
Scn8amed-TgA4Bs/Scn8amed-TgA4Bs B6.Cg-Scn8amed-TgA4Bs	abnormal eye electrophysiology	J:110231
Scn8amed-TgA4Bs/Scn8amed-TgA4Bs involves: C3H * C57BL/6J	decreased body weight	J:24228
	hindlimb paralysis	J:24228
	impaired balance	J:24228
	limb grasping	J:24228
	muscular atrophy	J:24228
	normal nervous system phenotype	J:24228
	premature death	J:24228
Scn8amed-TgA4Bs/Scn8anur14 involves: C3H * C57BL/6J	ataxia	J:146758
	postnatal lethality	J:146758
	tremors	J:146758
Scn8amed/Scn8a+ C3Fe.Cg-Scn8amed/J	abnormal spike wave discharge	J:147199
	decreased susceptibility to pharmacologically induced seizures	J:129998
Scn8amed/Scn8amed involves: C3HeB/FeJ * DBA/2J	abnormal eye electrophysiology	J:98511
Scn8amed/Scn8amed PCT	abnormal action potential	J:5192
	abnormal endplate potential	J:5192
	abnormal miniature endplate potential	J:5192
	abnormal muscle physiology	J:5192
	abnormal muscle tone	J:28679
	abnormal nerve conduction	J:6888
	abnormal neuromuscular synapse morphology	J:5153, J:28678
	demyelination	J:6888, J:7297
	hindlimb paralysis	J:28679
	muscular atrophy	J:5153
	paraparesis	J:28679
	postnatal lethality	J:5153, J:28678, J:28679
	progressive muscle weakness	J:5153, J:28678
Scn8anur14/Scn8anur14 C57BL/6J-Scn8anur14	ataxia	J:146758
	hindlimb paralysis	J:146758
	premature death	J:146758
	tremors	J:146758
Scn8anur14/Scn8anur14 involves: C57BL/6J	hindlimb paralysis	J:85113
	postnatal lethality, complete penetrance	J:85113
Scn8atm1Mm/Scn8atm1Mm Tg(Zp3-cre)3Mrt/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	ataxia	J:91696
	hindlimb paralysis	J:91696
	premature death	J:91696