Cish Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cish
cytokine inducible SH2-containing protein
MGI:103159

22 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cish^tm1.1Cdon/Cish^tm1.1Cdon Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ involves: 129S/Sv * 129X1/SvJ * C57BL/6	normal immune system phenotype	J:204829
Cish^tm1.1Cdon/Cish^tm1.1Cdon Tg(Cd4-cre)1Cwi/0 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2	abnormal T-helper 2 cell differentiation	J:204829
	increased eosinophil cell number	J:204829
	increased interleukin-4 secretion	J:204829
	increased interleukin-5 secretion	J:204829
	increased interleukin-10 secretion	J:204829
	increased interleukin-13 secretion	J:204829
	increased susceptibility to type I hypersensitivity reaction	J:204829
Cish^tm1.1Khk/Cish^tm1.1Khk Tg(Ins1-EGFP)1Hara/0 Tg(Pdx1-cre)89.1Dam/0 involves: C57BL/6 * CBA * CD-1	normal endocrine/exocrine gland phenotype	J:203844
	normal homeostasis/metabolism phenotype	J:203844
Cish^tm1.2Cdon/Cish^tm1.2Cdon B6.129S6(Cg)-Cish^tm1.2Cdon	abnormal CD4-positive T cell differentiation	J:204829
	abnormal immune system morphology	J:204829
	abnormal immune system physiology	J:204829
	abnormal respiratory mucosa goblet cell morphology	J:204829
	abnormal T-helper 2 cell differentiation	J:204829
	normal immune system phenotype	J:204829
	increased eosinophil cell number	J:204829
	increased interleukin-4 secretion	J:204829
	increased interleukin-5 secretion	J:204829
	increased interleukin-9 secretion	J:204829
	increased interleukin-13 secretion	J:204829
	increased lymphocyte cell number	J:204829
	increased susceptibility to type I hypersensitivity reaction	J:204829
	increased T cell proliferation	J:204829
	lung inflammation	J:204829
	lymph node hyperplasia	J:204829
	pulmonary fibrosis	J:204829
	spleen hyperplasia	J:204829
	thymus hyperplasia	J:204829

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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