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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Stat3
signal transducer and activator of transcription 3
MGI:103038
37 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Fgfr1tm5.1Sor/Fgfr1tm10.1Sor
Stat3tm2Aki/Stat3tm2Aki
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129P2/OlaHsd * 129S4/SvJaeSor 		normal craniofacial phenotype J:226497
Gt(ROSA)26Sortm1(Stat3*A661C*N663C)Sbkv/?
Tg(Fabp4-cre/ERT2)1Ipc/0
Tyk2tm1Shmd/Tyk2tm1Shmd
involves: 129P2/OlaHsd * C57BL/6 * SJL 		normal adipose tissue phenotype J:195099
normal homeostasis/metabolism phenotype J:195099
Il6sttm1Ern/Il6sttm1Ern
Stat3tm1Aki/Stat3+
involves: 129P2/OlaHsd * 129S1/Sv 		decreased circulating interleukin-6 level J:168781
decreased susceptibility to endotoxin shock J:168781
normal digestive/alimentary phenotype J:100160
normal immune system phenotype J:100160, J:139226, J:142883
normal mortality/aging J:100160
normal neoplasm J:100160
Il12btm1Jm/Il12btm1Jm
Stat3tm2Aki/Stat3tm2Aki
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 		normal digestive/alimentary phenotype J:83280
Pdpk1tm1Maka/Pdpk1tm1Maka
Stat3tm2Aki/Stat3tm2Aki
Tg(Alb1-cre)1Dlr/0
involves: 129S4/SvJae * 129P2/OlaHsd * FVB/N 		abnormal glucose homeostasis J:109359
impaired glucose tolerance J:109359
Ptpn11tm1Gsf/Ptpn11tm1Gsf
Stat3tm1Vpo/Stat3tm1Vpo
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA 		increased circulating alanine transaminase level J:172422
increased incidence of tumors by chemical induction J:172422
liver inflammation J:172422
Ptpn11tm1Gsf/Ptpn11tm1Gsf
Stat3tm1Xyfu/Stat3tm1Xyfu
Tg(Six3-cre)69Frty/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		retina degeneration J:174095
retina ganglion cell degeneration J:174095
retina outer nuclear layer degeneration J:174095
thin retina ganglion layer J:174095
thin retina inner nuclear layer J:174095
thin retina outer nuclear layer J:174095
thin retina outer plexiform layer J:174095
Stat1tm1Rds/Stat1tm1Rds
Stat3tm2Aki/Stat3tm2Aki
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 		abnormal colon morphology J:83280
colitis J:83280
increased CD4-positive, alpha-beta T cell number J:83280
increased interferon-gamma secretion J:83280
increased interleukin-6 secretion J:83280
increased tumor necrosis factor secretion J:83280
Stat3tm2Aki/Stat3tm2Aki
Tlr4tm1Aki/Tlr4tm1Aki
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6 		colitis J:83280
decreased interferon-gamma secretion J:83280
decreased susceptibility to endotoxin shock J:83280
Stat3tm2Aki/Stat3tm2Aki
Tnftm1Sek/Tnftm1Sek
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6 * CBA 		colitis J:83280
increased interferon-gamma secretion J:83280
increased interleukin-6 secretion J:83280
increased interleukin-12b secretion J:83280
Stat3tm4Vpo/Stat3tm4Vpo
Tg(MMTV-Erbb2)1Pv/0
involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CD-1 * DBA 		abnormal actin cytoskeleton morphology J:157976
abnormal cell adhesion J:157976
abnormal cell migration J:157976
decreased apoptosis J:157976
increased mammary adenocarcinoma incidence J:157976
increased mammary gland tumor incidence J:157976
increased metastatic potential J:157976
increased tumor growth/size J:157976
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory