About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Stat5a
signal transducer and activator of transcription 5A
MGI:103036
80 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm3(CAG-EYFP)Hze/Gt(ROSA)26Sor+
Stat5atm2Mam Stat5btm1Mam/Del(11Stat5a-Stat5b)1Mam
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA 		abnormal CD4-positive T cell differentiation J:204829
Myf5tm3(cre)Sor/Myf5+
Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(Alb1-cre)1Dlr/0
involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N 		decreased body length J:119237
decreased body weight J:119237
decreased circulating insulin-like growth factor I level J:119237
decreased lean body mass J:119237
increased total body fat amount J:119237
Nr3c1tm2Gsc/Nr3c1tm2Gsc
Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(Alb1-cre)7Gsc/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N 		decreased body weight J:121556
Stat5atm1.1Wjl/Stat5atm1.1Wjl
Stat5btm2.1Wjl/Stat5btm2.1Wjl
involves: 129S6/SvEvTac * C57BL/6J * FVB/N 		abnormal leukocyte morphology J:187325
abnormal regulatory T cell physiology J:187325
abnormal T cell subpopulation ratio J:187325
decreased CD8-positive, alpha-beta T cell number J:187325
decreased erythrocyte cell number J:187325
decreased hematocrit J:187325
decreased hemoglobin content J:187325
decreased NK cell number J:187325
decreased T cell proliferation J:187325
increased T cell apoptosis J:187325
Stat5atm1Jni/Stat5atm1Jni
Stat5btm2Jni/Stat5btm2Jni
either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ) 		abnormal fat pad morphology J:77412
abnormal liver physiology J:77412
abnormal myelopoiesis J:77412
decreased body weight J:77412
decreased corpora lutea number J:77412
decreased leukocyte cell number J:77412
decreased T cell number J:77412
female infertility J:77412
increased neutrophil cell number J:77412
Stat5atm1Jni/Stat5atm1Jni
Stat5btm2Jni/Stat5btm2Jni
involves: 129 * C57BL/6 		abnormal mast cell differentiation J:84889
abnormal mast cell physiology J:84889
absent mast cells J:84889
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:122463
premature death J:122463
Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5b+
involves: 129S6/SvEvTac 		abnormal lymphopoiesis J:258967
Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
involves: 129S6/SvEvTac * Black Swiss 		no abnormal phenotype detected J:92770
Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Myf5tm3(cre)Sor/Myf5+
involves: 129S4/SvJaeSor * 129S6/SvEvTac 		decreased body length J:119237
decreased body weight J:119237
decreased circulating insulin-like growth factor I level J:119237
decreased lean body mass J:119237
impaired glucose tolerance J:119237
increased circulating triglyceride level J:119237
increased total body fat amount J:119237
Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(Alb1-cre)7Gsc/0
involves: 129S6/SvEvTac * FVB/N 		decreased body weight J:121556
Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(Cd4-cre)1Cwi/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2 		increased circulating interleukin-17 level J:120176
increased interleukin-17 secretion J:120176
Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(Ins2-cre)25Mgn/0
involves: 129S6/SvEvTac * C57BL/6 * DBA 		decreased insulin secretion J:127051
disorganized pancreatic islets J:127051
impaired glucose tolerance J:127051
increased circulating free fatty acids level J:127051
increased circulating glucose level J:127051
increased circulating leptin level J:127051
increased total body fat amount J:127051
obese J:127051
Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(Lck-cre)I57Jxm/0
involves: 129 * 129S6/SvEvTac * C57BL/6 * ICR 		abnormal acute inflammation J:122463
abnormal T cell subpopulation ratio J:122463
decreased CD8-positive, alpha-beta T cell number J:122463
enlarged spleen J:122463
Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(MMTV-cre)1Mam/0
involves: 129S6/SvEvTac * FVB/N 		abnormal mammary gland alveolus morphology J:153755
abnormal mammary gland growth during lactation J:153755
lactation failure J:153755
Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(MMTV-cre)1Mam/0
Tg(MMTV-rtTA)1Lach/0
Tg(tetO-Stat5a)#Mam/0
involves: 129S6/SvEvTac * C57BL/6J * FVB/N 		normal endocrine/exocrine gland phenotype J:153755
normal reproductive system phenotype J:153755
Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(MMTV-cre)4Mam/0
involves: 129S6/SvEvTac * Black Swiss * FVB 		abnormal branching of the mammary ductal tree J:92770
abnormal milk ejection J:92770
Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA 		abnormal leukopoiesis J:155489
abnormal neutrophil differentiation J:155489
abnormal neutrophil physiology J:155489
anemia J:155489
decreased cell proliferation J:155489
decreased erythrocyte cell number J:155489
decreased hematocrit J:155489
decreased hemoglobin content J:155489
decreased leukocyte cell number J:155489
decreased lymphocyte cell number J:155489
decreased monocyte cell number J:155489
decreased neutrophil cell number J:155489
increased apoptosis J:155489
Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(Nes-cre)1Kln/0
involves: 129 * 129S6/SvEvTac * C57BL/6 * SJL 		abnormal fat pad morphology J:132806
decreased oxygen consumption J:132806
impaired adaptive thermogenesis J:132806
impaired glucose tolerance J:132806
increased circulating free fatty acids level J:132806
increased circulating insulin level J:132806
increased circulating leptin level J:132806
increased circulating triglyceride level J:132806
increased lean body mass J:132806
increased percent body fat/body weight J:132806
increased total body fat amount J:132806
increased total fat pad weight J:132806
insulin resistance J:132806
obese J:132806
polyphagia J:132806
Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(Pdx1-cre)89.1Dam/0
involves: 129S6/SvEvTac * C57BL/6 * CBA 		disorganized pancreatic islets J:127051
impaired glucose tolerance J:127051
Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(Tek-cre)1Ywa/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal proerythroblast morphology J:138904
anisocytosis J:138904
decreased erythrocyte cell number J:138904
decreased erythroid progenitor cell number J:138904
decreased hematocrit J:138904
decreased mean corpuscular hemoglobin J:138904
hypochromic microcytic anemia J:138904
increased apoptosis J:138904
increased circulating iron level J:138904
increased liver iron level J:138904
increased red blood cell distribution width J:138904
microcytosis J:138904
poikilocytosis J:138904
reticulocytosis J:138904
Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(Wap-cre)11738Mam/0
involves: 129S6/SvEvTac * Black Swiss 		abnormal mammary gland alveolus morphology J:92770
abnormal mammary gland epithelium physiology J:92770
increased mammary gland apoptosis J:92770
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory