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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
E2f4
E2F transcription factor 4
MGI:103012
56 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
E2f4tm1Jrn/E2f4tm1Jrn
involves: 129P2/OlaHsd * C57BL/6
abnormal colon goblet cell morphology J:64192
abnormal crypts of Lieberkuhn morphology J:64192
abnormal definitive hematopoiesis J:64192
abnormal granulocyte morphology J:64192
abnormal intestinal epithelium morphology J:64192
abnormal intestinal mucosa morphology J:64192
abnormal reticulocyte morphology J:64192
abnormal small intestinal villus morphology J:64192
abnormal small intestine goblet cell morphology J:64192
abnormal small intestine morphology J:64192
abnormal vocalization J:64192
anemia J:64192
broad head J:64192
decreased body size J:64192
decreased double-positive T cell number J:64192
decreased fetal size J:64192
decreased granulocyte number J:64192
decreased hematocrit J:64192
decreased small intestinal villus size J:64192
decreased thymocyte number J:64192
hemorrhage J:64192
hyperresponsive J:64192
increased double-negative T cell number J:64192
increased NK cell number J:64192
increased number of Howell-Jolly bodies J:64192
macrocytosis J:64192
postnatal lethality, incomplete penetrance J:64192
premature death J:64192
reduced fertility J:64192
short snout J:64192
spontaneous skin ulceration J:64192
thymus hypoplasia J:64192
E2f4tm1Lees/E2f4tm1Lees
involves: 129S2/SvPas * C57BL/6
abnormal food intake J:64193
abnormal intestine morphology J:64193
abnormal middle ear morphology J:64193
abnormal nasal cavity morphology J:64193
abnormal olfactory epithelium morphology J:64193
abnormal proerythroblast morphology J:64193
abnormal stress erythropoiesis J:64193
abnormal turbinate morphology J:64193
abnormal vocalization J:64193
anemia J:64193
anisocytosis J:64193
broad snout J:64193
decreased body size J:64193
decreased body weight J:64193
decreased erythrocyte cell number J:64193
decreased hematocrit J:64193
dehydration J:64193
embryonic growth retardation J:64193
increased nucleated erythrocyte cell number J:64193
increased number of Howell-Jolly bodies J:64193
increased susceptibility to bacterial infection J:64193
increased susceptibility to otitis media J:64193
macrocytosis J:64193
pallor J:64193
postnatal lethality, incomplete penetrance J:64193
reduced female fertility J:64193
reduced male fertility J:64193
reticulocytosis J:64193
rhinitis J:64193
short snout J:64193
E2f4tm2.1Lees/E2f4tm2.1Lees
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6
abnormal respiratory motile cilium morphology J:241925
E2f4tm2.1Lees/E2f4tm2.1Lees
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6
abnormal respiratory motile cilium morphology J:241925
E2f4tm2.1Lees/E2f4tm2.1Lees
Tg(Vil1-cre)20Syr/0
involves: 129S4/SvJae * C57BL/6 * DBA/2
no abnormal phenotype detected J:228346

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory