38 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Insrtm1Khn/Insrtm1Khn Pdx1tm1Ted/Pdx1+ Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ involves: 129S4/SvJae * C57BL/6 * DBA/2	decreased pancreatic beta cell mass	J:92861
Krastm5Tyj/Kras+ Pdx1tm1.1(flpo)Most/Pdx1+ Trp53tm1.1Dgk/Trp53+ involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * Black Swiss * C57BL/6	increased pancreatic ductal adenocarcinoma incidence	J:248550
	increased pancreatic intraepithelial neoplasia incidence	J:248550
	premature death	J:248550
Krastm5Tyj/Kras+ Pdx1tm1.1(flpo)Most/Pdx1+ Trp53tm1.1Dgk/Trp53tm1.1Dgk involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * Black Swiss * C57BL/6	increased pancreatic ductal adenocarcinoma incidence	J:248550
	increased pancreatic intraepithelial neoplasia incidence	J:248550
	premature death	J:248550
Neurog3tm1.1(cre/ERT)Ggu/Neurog3+ Pdx1tm1Macd/Pdx1+ Tg(tetO-Myt1)2Ggu/0 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ	abnormal pancreatic islet morphology	J:136131
Nkx6-1tm1.1Msan/Nkx6-1+ Pdx1tm1Cvw/Pdx1+ Tg(Neurog3-cre)C1Able/0 involves: 129/Sv * C57BL/6 * SJL	abnormal pancreatic islet morphology	J:195153
	decreased pancreatic beta cell number	J:195153
	increased pancreatic alpha cell number	J:195153
Pdx1tm1Cvw/Pdx1+ Pbx1tm1Mlc/Pbx1+ involves: 129S6/SvEvTac * C57BL/6	decreased insulin secretion	J:75811
	disorganized pancreatic islets	J:75811
	hyperglycemia	J:75811
	impaired glucose tolerance	J:75811
	increased insulin sensitivity	J:75811
	increased urine glucose level	J:75811
	weight loss	J:75811
Pdx1tm1Cvw/Pdx1+ SpopGt(BGB118)Byg/Spop+ involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal pancreatic beta cell morphology	J:165268
	abnormal pancreatic beta cell physiology	J:165268
	decreased insulin secretion	J:165268
	disorganized pancreatic islets	J:165268
	normal endocrine/exocrine gland phenotype	J:165268
	improved glucose tolerance	J:165268
	increased circulating glucose level	J:165268
Pdx1tm1Egs/Pdx1+ Stk11tm1.1Gne/Stk11tm1.1Gne involves: 129S1/Sv * C57BL/6N	increased cell proliferation	J:195229
	pancreas cyst	J:195229
Pdx1tm1Macd/Pdx1+ Tg(tetO-Neurog3)8Ggu/0 involves: 129S1/Sv * 129X1/SvJ	abnormal pancreas development	J:136131
Pdx1tm1Macd/Pdx1+ Tg(tetO-Myt1)2Ggu/0 involves: 129S1/Sv * 129X1/SvJ	abnormal pancreas development	J:136131
Pdx1tm1Macd/Pdx1+ Tg(tetO-Sox17,-EGFP)1Jaw/0 involves: 129S1/Sv * 129X1/SvJ	abnormal digestive system morphology	J:151981
	abnormal endocrine pancreas morphology	J:151981
	abnormal pancreas development	J:151981
	abnormal pancreas morphology	J:151981
	abnormal stomach morphology	J:151981
	normal digestive/alimentary phenotype	J:151981
	exocrine pancreas hyperplasia	J:151981
	normal liver/biliary system phenotype	J:151981
	pancreatic acinar hypoplasia	J:151981
	small pancreas	J:151981
	stomach epithelial hyperplasia	J:151981
Pdx1tm1Macd/Pdx1tm1Macd Tg(tetO-Ipf1,EGFP)956.6Macd/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	abnormal pancreas development	J:79206
	abnormal pancreatic beta cell morphology	J:101742
	decreased circulating glucose level	J:101742
	decreased insulin secretion	J:101742
	impaired glucose tolerance	J:79206, J:101742
	increased cell proliferation	J:101742
	increased circulating glucose level	J:79206
	increased glucagon secretion	J:101742
	small pancreatic islets	J:101742
Pdx1tm1Macd/Pdx1tm1Macd Tg(tetO-Ipf1,lacZ)958.1Macd/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	abnormal pancreas development	J:103522
	absent pancreas	J:103522
	impaired glucose tolerance	J:103522
Pdx1tm2Cvw/Pdx1+ Slc2a4tm1Mch/Slc2a4+ involves: 129/Sv * Black Swiss * C57BL/6 * SJL	decreased circulating insulin level	J:97234
	decreased insulin secretion	J:97234
	impaired glucose tolerance	J:97234
	increased circulating glucose level	J:97234
	pancreatic islet hyperplasia	J:97234