Bdkrb2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Bdkrb2
bradykinin receptor, beta 2
MGI:102845

24 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ace^tm4Keb/Ace^tm4Keb Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ	abnormal kidney vasculature morphology	J:83894
	abnormal response/metabolism to endogenous compounds	J:83894
	decreased hematocrit	J:83894
	decreased kidney weight	J:83894
	decreased systemic arterial systolic blood pressure	J:83894
	decreased urine osmolality	J:83894
	kidney cyst	J:83894
	vascular inflammation	J:83894
Bdkrb1^tm2Bdr/Bdkrb1^tm2Bdr Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh involves: 129S7/SvEvBrd * C57BL/6	normal cardiovascular system phenotype	J:135789
	decreased heart rate	J:135789
	decreased physiological sensitivity to xenobiotic	J:135789
	decreased susceptibility to endotoxin shock	J:135789
Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh Ins2^Akita/Ins2⁺ B6.Cg-Ins2^Akita Bdkrb2^tm1Jfh	abnormal intestinal epithelium morphology	J:108948
	abnormal Leydig cell morphology	J:108948
	abnormal mitochondrial chromosome morphology	J:108948
	abnormal seminiferous tubule morphology	J:108948
	abnormal spermatic cord morphology	J:108948
	abnormal spermatogonia morphology	J:108948
	alopecia	J:108948
	decreased bone mineral density	J:108948
	decreased subcutaneous adipose tissue amount	J:108948
	kyphosis	J:108948
	premature death	J:108948
Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh Serping1^Gt1Aed/Serping1^Gt1Aed involves: 129S5/SvEvBrd * C57BL/6	no abnormal phenotype detected	J:76090

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23