69 phenotypes from 8 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Fen1tm1Bew/Fen1tm1Bew involves: 129P2/OlaHsd * C57BL/6	prenatal lethality, complete penetrance	J:112968
Fen1tm1Bhsh/Fen1+ involves: 129S1/Sv	no abnormal phenotype detected	J:121378
Fen1tm1Bhsh/Fen1tm1Bhsh involves: 129S1/Sv	abnormal embryonic erythropoiesis	J:121378
	abnormal embryonic hematopoiesis	J:121378
	abnormal fibroblast physiology	J:121378
	abnormal lung development	J:121378
	decreased cell proliferation	J:121378
	decreased lung weight	J:121378
	embryonic growth retardation	J:121378
	neonatal lethality, complete penetrance	J:121378
	pale liver	J:121378
	pale spleen	J:121378
	pulmonary hypoplasia	J:121378
	thick lung-associated mesenchyme	J:121378
Fen1tm1Klng/Fen1+ involves: C57BL/6	no abnormal phenotype detected	J:84556
Fen1tm1Klng/Fen1tm1Klng involves: C57BL/6	abnormal blastocyst morphology	J:84556
	abnormal DNA repair	J:84556
	absent inner cell mass	J:84556
	decreased DNA replication	J:84556
	decreased trophoblast giant cell number	J:84556
	embryonic lethality before implantation, complete penetrance	J:84556
	increased cellular sensitivity to gamma-irradiation	J:84556
	inner cell mass degeneration	J:84556
Fen1tm1Rak/Fen1+ involves: 129/Sv * C57BL/6 * SJL/J	abnormal Paneth cell morphology	J:77962
	increased B cell derived lymphoma incidence	J:77962
	thymus atrophy	J:77962
Fen1tm1Rak/Fen1tm1Rak involves: 129/Sv * C57BL/6 * SJL/J	embryonic lethality before implantation, complete penetrance	J:77962
Fen1tm2.1Bhsh/Fen1+ involves: 129S1/Sv	aneuploidy	J:218627
	decreased fibroblast proliferation	J:218627
	spontaneous chromosome breakage	J:218627
Fen1tm2.1Bhsh/Fen1tm2.1Bhsh involves: 129S1/Sv	abnormal cell physiology	J:218627
	abnormal double-strand DNA break repair	J:218627
	abnormal telomere morphology	J:218627
	aneuploidy	J:218627
	chromosomal instability	J:218627
	decreased fibroblast proliferation	J:218627
	increased liver tumor incidence	J:218627
	increased lung tumor incidence	J:218627
	increased thymus tumor incidence	J:218627
	increased tumor incidence	J:218627
	spontaneous chromosome breakage	J:218627
Fen1tm2Klng/Fen1tm2Klng involves: 129X1/SvJ * C57BL/6	abnormal spleen B cell follicle morphology	J:138901
	abnormal spleen marginal zone morphology	J:138901
	decreased cell proliferation	J:138901
	enlarged spleen	J:138901
	normal immune system phenotype	J:138901
	increased B cell derived lymphoma incidence	J:138901
	increased fat cell size	J:138901
	increased lung adenoma incidence	J:138901
	increased sarcoma incidence	J:138901
	increased spleen B cell follicle number	J:138901
	increased spleen B cell follicle size	J:138901
	increased white adipose tissue amount	J:138901
	lymphoid hyperplasia	J:138901
	obese	J:138901
Fen1tm3.1Bhsh/Fen1+ Not Specified	chromosomal instability	J:231218
	chronic inflammation	J:231218
	enlarged spleen	J:231218
	extramedullary hematopoiesis	J:231218
	glomerulonephritis	J:231218
	increased anti-double stranded DNA antibody level	J:231218
	increased anti-nuclear antigen antibody level	J:231218
	increased cellular sensitivity to methylmethanesulfonate	J:231218
	increased lung adenoma incidence	J:231218
	increased plasma cell number	J:231218
	increased sensitivity to induced cell death	J:231218
	increased susceptibility to autoimmune disorder	J:231218
	interstitial pneumonia	J:231218
	lung inflammation	J:231218
	lymphoid hyperplasia	J:231218
	renal glomerular immunoglobulin deposits	J:231218
Fen1tm3.1Bhsh/Fen1tm3.1Bhsh Not Specified	abnormal cell physiology	J:231218
	chromosomal instability	J:231218
	chronic inflammation	J:231218
	enlarged spleen	J:231218
	extramedullary hematopoiesis	J:231218
	glomerulonephritis	J:231218
	increased anti-double stranded DNA antibody level	J:231218
	increased anti-nuclear antigen antibody level	J:231218
	increased cellular sensitivity to methylmethanesulfonate	J:231218
	increased gonad tumor incidence	J:231218
	increased kidney apoptosis	J:231218
	increased liver tumor incidence	J:231218
	increased lung adenocarcinoma incidence	J:231218
	increased lung adenoma incidence	J:231218
	increased lung apoptosis	J:231218
	increased plasma cell number	J:231218
	increased sensitivity to induced cell death	J:231218
	increased susceptibility to autoimmune disorder	J:231218
	interstitial pneumonia	J:231218
	lung inflammation	J:231218
	lymphoid hyperplasia	J:231218
	premature death	J:231218
	renal glomerular immunoglobulin deposits	J:231218
Fen1tm3Klng/Fen1tm3Klng involves: 129X1/SvJ * C57BL/6	abnormal cell physiology	J:138901
	abnormal embryo development	J:138901
	decreased embryo size	J:138901
	embryonic growth retardation	J:138901
	embryonic lethality during organogenesis, complete penetrance	J:138901
	open neural tube	J:138901