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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Mfge8
milk fat globule EGF and factor V/VIII domain containing
MGI:102768
25 phenotypes from 4 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Mfge8Gt(KST227)Byg/Mfge8Gt(KST227)Byg
B6.129P2-Mfge8Gt(KST227)Byg
abnormal kidney physiology J:98314
abnormal physiological neovascularization J:98314
enlarged spleen J:98314
impaired macrophage phagocytosis J:98314
reduced male fertility J:98314
Mfge8Gt(KST227)Byg/Mfge8Gt(KST227)Byg
involves: 129P2/OlaHsd * C57BL/6
abnormal involution of the mammary gland J:107106
abnormal mammary gland duct morphology J:107106
enlarged spleen J:107106
impaired macrophage phagocytosis J:107106
mastitis J:107106
reduced male fertility J:107106
Mfge8tm1Mcu/Mfge8tm1Mcu
involves: 129X1/SvJ * C57BL/6NCr
enlarged spleen J:123138
Mfge8tm1Osa/Mfge8tm1Osa
B6.129-Mfge8tm1Osa
abnormal involution of the mammary gland J:103839
abnormal mammary gland growth during lactation J:103839
abnormal milk composition J:103839
hypolactation J:103839
normal immune system phenotype J:187181
Mfge8tm1Osa/Mfge8tm1Osa
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal lactation J:103839
abnormal spleen morphology J:90633
enlarged spleen J:90633
impaired macrophage phagocytosis J:90633
increased anti-double stranded DNA antibody level J:225063
increased spleen B cell follicle size J:90633
increased spleen weight J:90633
increased spleen white pulp amount J:90633
spleen hyperplasia J:90633
Mfge8tm1Shur/Mfge8tm1Shur
B6.129-Mfge8tm1Shur
abnormal cell adhesion J:145962
abnormal epididymis morphology J:145962
epididymis epithelium degeneration J:145962
reduced male fertility J:145962
spermatic granuloma J:145962
Mfge8tm1Shur/Mfge8tm1Shur
involves: 129 * C57BL/6
decreased litter size J:85225
impaired binding of sperm to zona pellucida J:85225
reduced male fertility J:85225

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory