204 phenotypes from 7 alleles in 14 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cav1em2(IMPC)Ics/Cav1em2(IMPC)Ics C57BL/6N-Cav1em2(IMPC)Ics/Ics	decreased cardiac muscle contractility	J:211773
	decreased grip strength	J:211773
	increased circulating cholesterol level	J:211773
	increased circulating HDL cholesterol level	J:211773
	increased heart rate	J:211773
	increased hemoglobin content	J:211773
	increased mean corpuscular hemoglobin	J:211773
	increased mean corpuscular volume	J:211773
Cav1tm1.1Aia/Cav1tm1.1Aia involves: 129S7/SvEvBrd * C57BL/6J	abnormal uterus physiology	J:174719
	enlarged endometrial glands	J:174719
	increased endometrial gland number	J:174719
	normal neoplasm	J:174719
	ovary cyst	J:174719
	normal reproductive system phenotype	J:174719
	uterus cyst	J:174719
Cav1tm1Krc/Cav1tm1Krc involves: 129S4/SvJae * Black Swiss	abnormal nitric oxide homeostasis	J:78603
	absent caveolae	J:78603
	decreased heart left ventricle posterior wall thickness	J:78603
	decreased ventricle muscle contractility	J:78603
	dilated cardiomyopathy	J:78603
	dilated heart left ventricle	J:78603
	dilated heart right ventricle	J:78603
	heart right ventricle hypertrophy	J:78603
	increased heart left ventricle weight	J:78603
	pulmonary hypertension	J:78603
	thin interventricular septum	J:78603
Cav1tm1Kur/Cav1tm1Kur involves: 129X1/SvJ	abnormal thyroid follicular cell morphology	J:119709
Cav1tm1Kur/Cav1tm1Kur involves: 129X1/SvJ * C57BL/6	abnormal lipid level	J:112452
	abnormal liver physiology	J:112452
	abnormal type II pneumocyte morphology	J:71760
	abnormal vasoconstriction	J:71760
	absent caveolae	J:71760
	normal cellular phenotype	J:71760
	decreased hepatocyte proliferation	J:112452
	decreased liver triglyceride level	J:112452
	normal homeostasis/metabolism phenotype	J:71760
	impaired exercise endurance	J:71760
	impaired liver regeneration	J:112452
	increased lung endothelial cell proliferation	J:71760
	increased susceptibility to induced morbidity/mortality	J:112452
	increased vasodilation	J:71760
	pulmonary interstitial fibrosis	J:71760
	thick pulmonary interalveolar septum	J:71760
Cav1tm1Mls/Cav1tm1Mls B6.Cg-Cav1tm1Mls	abnormal brown fat cell morphology	J:105133
	abnormal fat cell morphology	J:205741
	abnormal lactation	J:120010
	abnormal lung vasculature morphology	J:205741
	abnormal mammary gland growth during pregnancy	J:120010
	abnormal triglyceride level	J:105133
	abnormal vascular endothelial cell morphology	J:205741
	absent caveolae	J:205741
	decreased core body temperature	J:105133
	decreased fatty acids level	J:105133
	impaired adaptive thermogenesis	J:105133
	impaired lipolysis	J:105133
	increased brown fat cell lipid droplet size	J:105133
Cav1tm1Mls/Cav1tm1Mls B6.Cg-Cav1tm1Mls/J	abnormal lung morphology	J:143600
	abnormal pulmonary elastic fiber morphology	J:143600
	abnormal respiratory mechanics	J:143600
	absent caveolae	J:143600
	decreased lung compliance	J:143600
	increased airway resistance	J:143600
	increased lung elastance	J:143600
	increased vascular permeability	J:143600
	pulmonary edema	J:143600
	reduced fertility	J:143600
Cav1tm1Mls/Cav1tm1Mls FVB.Cg-Cav1tm1Mls	abnormal adipose tissue physiology	J:182288
	abnormal cellular respiration	J:182288
	abnormal circulating amino acid level	J:182288
	abnormal free fatty acids level	J:182288
	abnormal glucose homeostasis	J:182288
	abnormal homeostasis	J:182288
	abnormal liver physiology	J:182288
	abnormal respiratory electron transport chain	J:182288
	abnormal respiratory quotient	J:182288
	abnormal skeletal muscle morphology	J:182288
	decreased circulating adiponectin level	J:182288
	decreased liver glycogen level	J:182288
	decreased susceptibility to diet-induced hepatic steatosis	J:182288
	decreased susceptibility to diet-induced obesity	J:182288
	decreased total body fat amount	J:182288
	enhanced gluconeogenesis	J:182288
	enhanced lipolysis	J:182288
	hyperglycemia	J:182288
	increased blood urea nitrogen level	J:182288
	increased circulating glycerol level	J:182288
	increased circulating insulin level	J:182288
	increased food intake	J:182288
	increased liver glycogen level	J:182288
	increased liver weight	J:182288
	increased oxygen consumption	J:182288
	increased respiratory quotient	J:182288
	increased triglyceride level	J:182288
	insulin resistance	J:182288
	weight loss	J:182288
Cav1tm1Mls/Cav1tm1Mls involves: 129/Sv * C57BL/6 * FVB/N * SJL	abnormal mammary gland morphology	J:147439
	increased mammary gland tumor incidence	J:147439
Cav1tm1Mls/Cav1tm1Mls involves: 129/Sv * C57BL/6 * SJL	abnormal blood homeostasis	J:75192
	abnormal bone mineralization	J:141361
	abnormal bone trabecula morphology	J:141361
	abnormal chemokine secretion	J:115914
	abnormal circulating free fatty acids level	J:75192
	abnormal compact bone morphology	J:141361
	abnormal cytokine level	J:115914
	abnormal fat cell morphology	J:75192
	abnormal gonadal fat pad morphology	J:75192
	abnormal homeostasis	J:116286
	abnormal lipid homeostasis	J:75192
	abnormal long bone epiphysis morphology	J:141361
	abnormal long bone metaphysis morphology	J:141361
	abnormal macrophage physiology	J:115914
	abnormal mammary fat pad morphology	J:75192
	abnormal mammary gland duct morphology	J:75192
	abnormal mammary gland epithelium morphology	J:109251
	abnormal mammary gland morphology	J:75192
	abnormal myocardium layer morphology	J:87282
	abnormal neutrophil physiology	J:139304
	abnormal nitric oxide homeostasis	J:139304
	abnormal osteoclast morphology	J:141361
	abnormal pulmonary alveolar parenchyma morphology	J:75193
	abnormal pulmonary endothelial cell surface	J:87282
	abnormal skeletal muscle fiber morphology	J:117199
	abnormal vasoconstriction	J:75193
	abnormal vasodilation	J:75193
	abnormal vesicle-mediated transport	J:73489
	absent caveolae	J:73489, J:75192, J:75193
	absent subcutaneous adipose tissue	J:75192
	cardiac fibrosis	J:87282
	cardiac hypertrophy	J:87282
	congestive heart failure	J:87282
	decreased body weight	J:75192
	decreased cardiac muscle contractility	J:87282
	decreased circulating leptin level	J:75192
	decreased subcutaneous adipose tissue amount	J:75192
	decreased susceptibility to diet-induced obesity	J:75192
	decreased susceptibility to endotoxin shock	J:139304
	decreased total body fat amount	J:75192
	decreased white adipose tissue amount	J:75192
	decreased white fat cell lipid droplet size	J:75192
	dilated heart right ventricle	J:87282
	epidermal hyperplasia	J:83485
	heart left ventricle hypertrophy	J:87282
	normal homeostasis/metabolism phenotype	J:75192
	impaired exercise endurance	J:75193
	impaired neutrophil recruitment	J:115914
	increased bone strength	J:141361
	increased bone trabecula number	J:141361
	increased brown adipose tissue amount	J:75192
	increased cerebral infarct size	J:133702
	increased circulating CXCL10 level	J:115914
	increased circulating interferon-gamma level	J:115914
	increased circulating interleukin-6 level	J:115914
	increased circulating triglyceride level	J:75192
	increased circulating tumor necrosis factor level	J:115914
	increased circulating VLDL triglyceride level	J:75192
	increased femoral compact bone area	J:141361
	increased food intake	J:75192
	increased heart left ventricle wall thickness	J:87282
	increased incidence of tumors by chemical induction	J:83485
	increased susceptibility to bacterial infection	J:115914
	increased susceptibility to bacterial infection induced morbidity/mortality	J:115914
increased trabecular bone thickness	J:141361
normal liver/biliary system phenotype	J:75192
lung inflammation	J:87282
mammary gland duct hyperplasia	J:109251
mammary gland hyperplasia	J:109251
myocardial fiber disarray	J:87282
normal neoplasm	J:109251
premature bone ossification	J:141361
premature death	J:87282
pulmonary hyperemia	J:87282
pulmonary hypertension	J:87282
slow postnatal weight gain	J:75192
thick interventricular septum	J:87282
thick pulmonary interalveolar septum	J:75193, J:87282
Cav1tm1Mls/Cav1tm1Mls involves: 129/Sv * C57BL/6J * SJL	abnormal actin cytoskeleton morphology	J:134719
	abnormal brain internal capsule morphology	J:110712
	abnormal cell morphology	J:134719
	abnormal cellular cholesterol metabolism	J:116292
	abnormal chondrocyte physiology	J:128103
	abnormal costochondral joint morphology	J:128103
	abnormal digestive system physiology	J:114334
	abnormal fat cell morphology	J:89326
	abnormal fibroblast chemotaxis	J:134719
	abnormal gait	J:110712
	abnormal hyaline cartilage morphology	J:128103
	abnormal involuntary movement	J:110712
	abnormal locomotor behavior	J:110712
	abnormal long bone epiphyseal plate morphology	J:128103
	abnormal long bone epiphyseal plate proliferative zone	J:128103
	abnormal long bone hypertrophic chondrocyte zone	J:128103
	abnormal long bone metaphysis morphology	J:128103
	abnormal microtubule organizing center morphology	J:134719
	abnormal nitric oxide homeostasis	J:114334
	abnormal trabecular bone morphology	J:128103
	abnormal vascular endothelial cell morphology	J:79595
	abnormal vascular wound healing	J:115492
	absent caveolae	J:114334, J:115492, J:128103
	decreased body weight	J:84260
	decreased brain size	J:110712
	decreased brain weight	J:110712
	decreased exploration in new environment	J:110712
	decreased fibroblast chemotaxis	J:134719
	decreased grip strength	J:110712
	decreased locomotor activity	J:110712
	decreased vasoconstriction	J:120603
	impaired lipolysis	J:89326
	impaired wound healing	J:134719
	increased circulating insulin level	J:84260
	increased long bone epiphyseal plate size	J:128103
	increased vascular permeability	J:79595
	insulin resistance	J:84260
	limb grasping	J:110712
	short stride length	J:110712
Cav1tm1Mls/Cav1tm1Mls Not Specified	abnormal astrocyte morphology	J:168335
	abnormal brain vasculature morphology	J:168335
	abnormal cell cytoskeleton morphology	J:168335
	abnormal CNS glial cell morphology	J:168335
	abnormal dendrite morphology	J:168335
	abnormal dentate gyrus morphology	J:168335
	abnormal hippocampus CA1 region morphology	J:168335
	amyloid beta deposits	J:168335
	astrocytosis	J:168335
	brain ischemia	J:168335
	decreased CNS synapse formation	J:168335
	hippocampal neuron degeneration	J:168335
	tau protein deposits	J:168335
Cav1tm1Mls/Cav1tm1Mls STOCK Cav1tm1Mls/J	abnormal thyroid follicular cell morphology	J:119709
	decreased body weight	J:132392
	decreased vasoconstriction	J:132392
	increased systemic arterial blood pressure	J:132392
	increased vasodilation	J:132392
Cav1tm1Pesch/Cav1tm1Pesch Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ FVB.Cg-Cav1tm1Pesch Speer6-ps1Tg(Alb-cre)21Mgn	decreased circulating glucose level	J:182288
	decreased circulating glycerol level	J:182288
	normal liver/biliary system phenotype	J:182288
Cav1tm1Tt/Cav1tm1Tt involves: 129S7/SvEvBrd * C57BL/6J	abnormal renal calcium reabsorption	J:82490
	increased kidney weight	J:82490
	increased urine calcium level	J:82490
	normal renal/urinary system phenotype	J:82490
	urolithiasis	J:82490