About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Runx3
runt related transcription factor 3
MGI:102672
106 phenotypes from 8 alleles in 15 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Runx3tm1b(KOMP)Wtsi/Runx3+
C57BL/6N-Runx3tm1b(KOMP)Wtsi/J 		abnormal locomotor behavior J:211773
increased fasting circulating glucose level J:211773
Runx3tm1b(KOMP)Wtsi/Runx3tm1b(KOMP)Wtsi
C57BL/6N-Runx3tm1b(KOMP)Wtsi/J 		preweaning lethality, complete penetrance J:211773
Runx3tm1Itan/Runx3tm1Itan
Tg(Cd4-cre)1Cwi/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal CD8-positive, alpha beta T cell morphology J:125953
abnormal CD8-positive, alpha-beta T cell differentiation J:125953
decreased CD8-positive, alpha-beta T cell number J:131081
increased IgA level J:125953
lung inflammation J:125953
Runx3tm1Litt/Runx3tm1Litt
involves: 129P2/OlaHsd 		abnormal CD8-positive, alpha-beta T cell differentiation J:141144
abnormal double-positive T cell morphology J:141144
Runx3tm1Yg/Runx3tm1Yg
either: (involves: 129S1/Sv * 129X1/SvJ * BALB/c) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) 		postnatal lethality J:93240
Runx3tm1Yg/Runx3tm1Yg
either: (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1) 		abnormal auchene hair morphology J:99572
abnormal cecum morphology J:93240
abnormal colon morphology J:93240
abnormal crypts of Lieberkuhn morphology J:93240
abnormal cytokine level J:93240
abnormal dendritic cell differentiation J:88424
abnormal dendritic cell morphology J:88424
abnormal dendritic cell physiology J:88424, J:100348
abnormal digestive system physiology J:93240
abnormal dorsal spinal root morphology J:77764
abnormal eating behavior J:93240
abnormal excitatory postsynaptic potential J:77764
abnormal gastric chief cell morphology J:93240
abnormal gastric parietal cell morphology J:93240
abnormal inflammatory response J:93240
abnormal interferon level J:93240
abnormal interleukin level J:93240
abnormal large intestine morphology J:93240
abnormal lung epithelium morphology J:88424
abnormal mesenteric lymph node morphology J:93240
abnormal muscle tone J:77764
abnormal nervous system electrophysiology J:77764
abnormal posture J:77764
abnormal respiratory system physiology J:88424
abnormal sensory neuron innervation pattern J:77764
abnormal sensory neuron morphology J:77764
abnormal spinal cord dorsal column morphology J:77764
abnormal spinal cord dorsal horn morphology J:77764
abnormal stomach mucosa morphology J:93240
abnormal tumor necrosis factor level J:93240
abnormal zigzag hair morphology J:99572
absent Langerhans cell J:88424
absent muscle spindles J:77764
ataxia J:77764
colitis J:93240
decreased body size J:77764
decreased body weight J:93240
decreased spinal cord size J:77764
decreased total body fat amount J:93240
increased airway responsiveness J:100348
increased dendritic cell number J:88424, J:100348
increased IgE level J:100348
intestinal inflammation J:93240
lordosis J:77764
lung inflammation J:88424
postnatal lethality, incomplete penetrance J:77764, J:93240
small dorsal root ganglion J:77764
small intestinal inflammation J:93240
sparse hair J:99572
stomach inflammation J:93240
Runx3tm1Yg/Runx3tm1Yg
involves: 129S1/Sv * 129X1/SvJ 		abnormal CD8-positive, alpha beta T cell morphology J:109584
abnormal muscle tone J:77764
abnormal posture J:77764
ataxia J:77764
decreased body size J:77764
lordosis J:77764
postnatal lethality J:77764
Runx3tm1Yg/Runx3tm1Yg
involves: 129S1/Sv * 129X1/SvJ * ICR 		abnormal bone mineralization J:224290
abnormal clavicle morphology J:224290
abnormal cranium morphology J:224290
abnormal gait J:243559
abnormal intramembranous bone ossification J:224290
abnormal skeleton development J:224290
abnormal skeleton morphology J:224290
abnormal trabecular bone morphology J:224290
ataxia J:243559
decreased body size J:224290
decreased bone mass J:224290
decreased bone mineral content J:224290
decreased bone mineral density J:224290
decreased bone mineral density of femur J:224290
decreased bone stiffness J:224290
decreased bone strength J:224290
decreased bone volume J:224290
decreased compact bone thickness J:224290
decreased diameter of femur J:224290
decreased length of long bones J:224290
decreased osteoblast cell number J:224290
decreased osteoblast proliferation J:224290
decreased skeletal muscle fiber size J:243559
decreased trabecular bone thickness J:224290
decreased trabecular bone volume J:224290
delayed bone ossification J:224290
kyphosis J:224290
scoliosis J:243559
short femur J:224290
short humerus J:224290
normal skeleton phenotype J:243559
small neurocranium J:224290
Runx3tm1Yito/Runx3tm1Yito
involves: 129P2/OlaHsd * C57BL/6 		abnormal stomach epithelium morphology J:75869
decreased circulating glucose level J:75869
increased stomach mucosa thickness J:75869
neonatal lethality, incomplete penetrance J:75869
postnatal lethality, complete penetrance J:75869
stomach mucosa hyperplasia J:75869
Runx3tm2Yg/Runx3tm2Yg
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR 		abnormal CD8-positive, alpha beta T cell morphology J:109584
abnormal dendritic cell differentiation J:109584
normal behavior/neurological phenotype J:109584
Runx3tm3.1Yg/Runx3tm3.1Yg
Not Specified 		abnormal behavior J:224898
abnormal digestive system physiology J:224898
abnormal immune system physiology J:224898
absent Langerhans cell J:224898
ataxia J:224898
decreased body height J:224290
decreased body weight J:224290
decreased bone mineral content J:224290
decreased bone mineral density J:224290
decreased compact bone area J:224290
intestinal inflammation J:224898
short femur J:224290
Runx3tm3Yg/Runx3tm3Yg
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: C57BL/6J * CBA/J 		abnormal gait J:243559
absent proprioceptive neurons J:243559
ataxia J:243559
scoliosis J:243559
Runx3tm3Yg/Runx3tm3Yg
Tg(Col1a1-cre)1Kry/0
involves: FVB/N 		decreased body height J:224290
decreased body mass index J:224290
decreased body size J:224290
decreased body weight J:224290
decreased bone mineral content J:224290
decreased diameter of femur J:224290
decreased femoral compact bone area J:224290
skeleton phenotype J:243559
Runx3tm3Yg/Runx3tm3Yg
Tg(Col2a1-cre)1Bhr/0
involves: C57BL/6 * SJL 		decreased body height J:224290
normal skeleton phenotype J:224290, J:243559
Runx3tm3Yg/Runx3tm3Yg
Tg(Pou4f1-cre/ERT2)2Jiz/0
involves: C57BL/6 		abnormal gait J:243559
abnormal proprioceptive neuron morphology J:243559
ataxia J:243559
scoliosis J:243559
Runx3tm3Yg/Runx3tm3Yg
Tg(Scx-GFP)1Stzr/0
Not Specified 		skeleton phenotype J:243559
Runx3tm3Yg/Runx3tm3Yg
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: CD-1 		decreased body size J:224290
decreased survivor rate J:224290
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory