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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Msh2
mutS homolog 2
MGI:101816
40 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
ApcMin/Apc+
Msh2tm1Mak/Msh2+
Nos2tm1Mrl/Nos2tm1Mrl
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J 		intestine polyps J:200824
ApcMin/Apc+
Msh2tm1Mak/Msh2tm1Mak
involves: 129P2/OlaHsd * C57BL/6J 		anemia J:75393
increased intestinal adenoma incidence J:75393
intestinal obstruction J:75393
intestine polyps J:200824
premature death J:75393
ApcMin/Apc+
Msh2tm1Mak/Msh2tm1Mak
Nos2tm1Mrl/Nos2tm1Mrl
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J 		intestine polyps J:200824
ApcMin/Apc+
Msh2tm1Htr/Msh2tm1Htr
involves: 129P2/OlaHsd * BALB/c * C57BL/6J 		increased gastrointestinal tumor incidence J:45433
premature death J:45433
Apctm1Rak/Apc+
Msh2tm1Rak/Msh2tm1Rak
involves: 129P2/OlaHsd 		increased tumor incidence J:64667
premature death J:64667
B4galnt2a/B4galnt2b
Msh2tm1Htr/Msh2tm1Htr
involves: 129P2/OlaHsd * BALB/c * SWR 		decreased enterocyte apoptosis J:54082
Fam72atm1.1(KOMP)Vlcg/Fam72atm1.1(KOMP)Vlcg
Msh2tm1Mak/Msh2tm1Mak
C57BL/6NTac-Fam72atm1.1(KOMP)Vlcg Msh2tm1Mak 		abnormal class switch recombination J:326431
abnormal somatic hypermutation frequency J:326431
Hrhr/Hrhr
Msh2tm1Htr/Msh2tm1Htr
involves: 129P2/OlaHsd 		increased incidence of tumors by UV-induction J:79734
increased lymphoma incidence J:79734
increased mortality induced by ionizing radiation J:79734
increased skin papilloma incidence J:79734
increased skin squamous cell carcinoma incidence J:79734
increased skin tumor incidence J:79734
premature death J:79734
Hrhr/Hrhr
Msh2tm1Htr/Msh2tm1Htr
Xpatm1Tnka/Xpatm1Tnka
involves: 129P2/OlaHsd * C57BL/6 * CBA 		increased incidence of tumors by UV-induction J:79734
increased lymphoma incidence J:79734
increased mortality induced by ionizing radiation J:79734
increased skin papilloma incidence J:79734
increased skin squamous cell carcinoma incidence J:79734
increased skin tumor incidence J:79734
premature death J:79734
Htttm5Mem/Htt+
Msh2tm1Htr/Msh2tm1Htr
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1 * FVB/N 		neuronal intranuclear inclusions J:81666
Msh2tm1Htr/Msh2tm1Htr
Pcnatm1Jcbs/Pcnatm1Jcbs
involves: 129P2/OlaHsd 		abnormal somatic hypermutation frequency J:155454
Msh2tm1Htr/Msh2tm1Htr
Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu
Ungtm1Tld/Ungtm1Tld
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N 		increased lymphoma incidence J:197809
increased tumor incidence J:197809
premature death J:197809
preweaning lethality, incomplete penetrance J:197809
Msh2tm1Htr/Msh2tm1Htr
Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu
Ungtm1Tld/Ungtm1Tld
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N 		increased lymphoma incidence J:197809
increased tumor incidence J:197809
premature death J:197809
preweaning lethality, incomplete penetrance J:197809
Msh2tm1Htr/Msh2tm1Htr
Tap1tm1Hpl/Tap1tm1Hpl
involves: 129P2/OlaHsd * FVB 		increased gastrointestinal tumor incidence J:45433
increased lung tumor incidence J:45433
increased mammary gland tumor incidence J:45433
increased skin tumor incidence J:45433
increased tumor incidence J:45433
increased uterus tumor incidence J:45433
Msh2tm1Mak/Msh2+
Mutyhtm1Jhmi/Mutyhtm1Jhmi
Ogg1tm1Tld/Ogg1tm1Tld
involves: 129 * C57BL/6J 		increased lung adenocarcinoma incidence J:89742
increased lung adenoma incidence J:89742
increased lymphoma incidence J:89742
increased ovary tumor incidence J:89742
increased tumor incidence J:89742
premature death J:89742
Msh2tm1Mak/Msh2tm1Mak
Mutyhtm1Jhmi/Mutyhtm1Jhmi
Ogg1tm1Tld/Ogg1tm1Tld
involves: 129 * C57BL/6J 		increased lung adenoma incidence J:89742
increased lymphoma incidence J:89742
increased tumor incidence J:89742
premature death J:89742
Msh2tm1Rak/Msh2tm1Rak
Pold1tm1.1Bdp/Pold1tm1.1Bdp
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J 		postnatal lethality, complete penetrance J:153684
Msh2tm1Rak/Msh2tm1Rak
Poletm1.1Bdp/Poletm1.1Bdp
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J 		postnatal lethality, complete penetrance J:153684
Msh2tm1Rak/Msh2tm1Rak
Xpctm1Ecf/Xpctm1Ecf
involves: 129P2/OlaHsd * SKH1 		abnormal cell cycle J:94447
increased cellular sensitivity to ultraviolet irradiation J:94447
Msh2tm1Tts/Msh2tm1Tts
Nudt1tm1Tts/Nudt1tm1Tts
involves: 129S/SvEv * C57BL/6J 		abnormal cell physiology J:79732
Msh2tm1Wed/Msh2tm1Wed
involves: 129 * C57BL/6 * SJL 		abnormal mismatch repair J:88092
decreased survivor rate J:88092
increased intestinal adenocarcinoma incidence J:88092
increased lymphoma incidence J:88092
increased tumor incidence J:88092
increased tumor latency J:88092
premature death J:88092
Msh2tm1Wed/Msh2tm1Wed
involves: C57BL/6 		abnormal class switch recombination J:86278
decreased IgG level J:86278
increased intestinal adenocarcinoma incidence J:86278
increased lymphoma incidence J:86278
Msh2tm1Whl/Msh2tm1Whl
Rb1tm1Brd/Rb1+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J 		abnormal definitive hematopoiesis J:79016
abnormal tumor morphology J:79016
increased gastrointestinal tumor incidence J:79016
increased lymphoblastic lymphoma incidence J:79016
increased pheochromocytoma incidence J:79016
increased pituitary adenohypophysis tumor incidence J:79016
increased pituitary melanotroph tumor incidence J:79016
increased skin tumor incidence J:79016
increased thyroid C-cell carcinoma incidence J:79016
increased tumor incidence J:79016
premature death J:79016
Msh2tm1Whl/Msh2tm1Whl
Rb1tm1Brd/Rb1tm1Brd
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J 		abnormal definitive hematopoiesis J:79016
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory