Cfl1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cfl1
cofilin 1, non-muscle
MGI:101757

19 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cap1^tm1.1Mbrst/Cap1^tm1.1Mbrst Cfl1^tm1.1Wit/Cfl1^tm1.1Wit Tg(Nes-cre)1Kln/0 involves: 129 * C57BL/6 * SJL	impaired neuron differentiation	J:333563
Cfl1^c5/Cfl1^c5 Dstn^corn1/Dstn⁺ involves: A/WySn * C57BL/6J	abnormal primitive node morphology	J:194042
	embryonic growth arrest	J:194042
	embryonic lethality	J:194042
Cfl1^c5/Cfl1^c5 Dstn^corn1/Dstn^corn1 involves: A/WySn * C57BL/6J	embryonic lethality before implantation, complete penetrance	J:194042
Cfl1^c5/Cfl1^c5 Vangl2^Lp/Vangl2^Lp involves: C57BL/6J * LPT/LeJ	abnormal direction of heart looping	J:194042
	abnormal embryo turning	J:194042
	abnormal embryonic cilium location or orientation	J:194042
	abnormal heart looping	J:194042
	abnormal left-right axis patterning	J:194042
	abnormal notochord morphology	J:194042
	abnormal primitive node morphology	J:194042
	abnormal somite development	J:194042
	abnormal somite size	J:194042
	decreased embryo size	J:194042
	embryonic growth arrest	J:194042
	embryonic lethality during organogenesis, complete penetrance	J:194042
	failure of heart looping	J:194042
	heterotaxia	J:194042
	open neural tube	J:194042
Cfl1^tm1.1Wit/Cfl1⁺ Dstn^tm1.1Wit/Dstn^tm1.1Wit Tg(Nes-cre)1Kln/0 involves: 129 * BALB/cJ * C57BL/6 * SJL	no abnormal phenotype detected	J:125317
Cfl1^tm1.2Wit/Cfl1^tm1.2Wit Vangl2^Lp/Vangl2^Lp involves: 129 * LPT/LeJ	abnormal embryo turning	J:194042
	abnormal somite development	J:194042
	decreased embryo size	J:194042
	embryonic growth arrest	J:194042
	embryonic lethality during organogenesis, complete penetrance	J:194042
	open neural tube	J:194042

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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