About   Help   FAQ
Hr
Gene Detail
 Symbol
Name
ID
Hr
hairless
MGI:96223
Synonyms ba, bldy, N, rh, rh-bmh
Feature Type protein coding gene
Genetic Map
Chromosome 14
36.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(28)
Sequence Map
Chr14:70552212-70573548 bp, + strand
From VEGA annotation of GRCm38

  21337 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:3774  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Hr
Human
homologs
Human Homolog HR, hair growth associated
NCBI Gene ID 55806
neXtProt AC  NX_O43593
Human Synonyms  ALUNC, AU, HSA277165, MUHH, MUHH1
Human Chr (Location)  8p21.2; chr8:21971932-21988565 (-)  GRCh37.p10
Disease Associations  (3) Diseases Associated with Human HR
Alleles
and
phenotypes 		All alleles(29) : Targeted(3) Transgenic(1) Spontaneous(17) Chemically induced(8)
 
Mutant homozygotes exhibit hair loss, usually wrinkled skin with epidermal cysts. Females do not nurse their pups well.
 
Human Diseases Modeled Using Mouse Hr (3)    Alleles Annotated to Human Diseases(4)    Phenotype Images(9)
Gene Ontology
(GO)
classifications 		All GO classifications: (16 annotations)
Process negative regulation of sequence-specific DNA binding transcription factor activity, negative regulation of transcription, DNA-dependent, ...
Component histone deacetylase complex, nuclear body, ...
Function DNA binding, histone deacetylase binding, ...
External Resources: FuncBase
Expression Literature Summary: (6 records)
Data Summary: Results (33)    Tissues (18)    Images (4)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 25
Northern blot 8
cDNA source data(39)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(51) Genomic(10) cDNA(39) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034183 (Evidence)
Ensembl Gene ModelENSMUSG00000022096 (Evidence)
Entrez Gene15460 (Evidence)
UniGene7598
DFCITC1581479
DoTSDT.40152518
NIA Mouse Gene IndexU015825
Consensus CDS ProjectCCDS27257.1
International Mouse Knockout Project StatusHr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034183 VEGA Gene Model | MGI Sequence Detail 21337 C57BL/6J ±  kb
transcript OTTMUST00000086690 VEGA | MGI Sequence Detail 5278 Not Applicable 
polypeptide OTTMUSP00000046950 VEGA | MGI Sequence Detail 1211 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(3)
Polymorphisms All PCR and RFLP(6) : PCR(3) RFLP(3) SNPs(95 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR003347 JmjC domain
Protein Ontology PR:000008744 protein hairless
References (Earliest) J:2405 Brooke HC, Hairless mice. J Hered. 1926;17:173-74
(Latest) J:192868 Kumpf S, et al., Hairless promotes PPARgamma expression and is required for white adipogenesis. EMBO Rep. 2012 Nov 6;13(11):1012-20
All references(222)
Other
accession IDs 		MGD-MRK-10929, MGI:1890458, MGI:2661845
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
05/22/2013
MGI 5.13 		The Jackson Laboratory