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H2-Eb1
Gene Detail
 Symbol
Name
ID
H2-Eb1
histocompatibility 2, class II antigen E beta
MGI:95901
Synonyms H-2Eb, Ia4, Ia-4
Feature Type protein coding gene
Genetic Map
Chromosome 17
17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(29)
Sequence Map
Chr17:34305883-34316199 bp, + strand
From VEGA annotation of GRCm38

  10317 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:128336  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle

Gene Tree: H2-Eb1
Human
homologs
Human Homolog HLA-DRB1, major histocompatibility complex, class II, DR beta 1
NCBI Gene ID 3123
neXtProt AC  NX_P01911, NX_P01912, NX_Q29974
Human Synonyms  DRB1, DRw10, HLA-DR1B, HLA-DRB, SS1
Human Chr (Location)  6p21.3; chr6:32546546-32557613 (-)  GRCh37.p10
Disease Associations  (3) Diseases Associated with Human HLA-DRB1
Alleles
and
phenotypes 		All alleles(3) : Targeted(2) Gene trapped(1)
Gene Ontology
(GO)
classifications 		All GO classifications: (32 annotations)
Process antigen processing and presentation, antigen processing and presentation of exogenous peptide antigen via MHC class II, ...
Component integral to membrane, late endosome membrane, ...
Function protein binding
External Resources: FuncBase
Expression Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (1)   
Theiler Stages: 26
Assay TypeResults
RT-PCR 2
cDNA source data(149)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(198) Genomic(37) cDNA(153) Primer pair(6) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037123 (Evidence)
Ensembl Gene ModelENSMUSG00000060586 (Evidence)
Entrez Gene14969 (Evidence)
UniGene22564
DFCITC1571946, TC1696751
DoTSDT.101177272, DT.493389
NIA Mouse Gene IndexU017851
PDB1IEB, 1R5V, 1R5W, 3QIB, 3QIU, 3QIW
Consensus CDS ProjectCCDS37584.1
International Mouse Knockout Project StatusH2-Eb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037123 VEGA Gene Model | MGI Sequence Detail 10317 C57BL/6J ±  kb
transcript OTTMUST00000095581 VEGA | MGI Sequence Detail 1178 Not Applicable 
polypeptide OTTMUSP00000053332 VEGA | MGI Sequence Detail 264 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(2) UniProt(17)
Polymorphisms All PCR and RFLP(38) : PCR(7) RFLP(31) SNPs(125 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR011162 MHC classes I/II-like antigen recognition protein
InterPro IPR014745 MHC class II, alpha/beta chain, N-terminal
InterPro IPR000353 MHC class II, beta chain, N-terminal
Protein Ontology PR:000002019 MHC class II histocompatibility antigen beta chain HLA-DRB1
References (Earliest) J:5682 Murphy DB, et al., A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes. J Exp Med. 1976 Sep 1;144(3):699-712
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(75)
Other
accession IDs 		MGD-MRK-10384, MGD-MRK-10497, MGD-MRK-11047, MGD-MRK-11052
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/05/2013
MGI 5.13 		The Jackson Laboratory