Nr3c1 MGI Mouse Gene Detail - MGI:95824 - nuclear receptor subfamily 3, group C, member 1

Nr3c1
Gene Detail

Symbol
Name
ID

Nr3c1
nuclear receptor subfamily 3, group C, member 1
MGI:95824

STS

D18Mit17

Synonyms

glucocorticoid receptor, GR, Grl1, Grl-1

Feature Type

protein coding gene

Genetic Map

Chromosome 18

21.09 cM
Detailed Genetic Map ± 1 cM

Mapping data(30)

Sequence Map

Chr18:39410545-39491301 bp, - strand
From VEGA annotation of GRCm38

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:30960 Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glucocorticoid receptor
Gene Tree: Nr3c1

Human
homologs

Human Homolog		NR3C1, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NCBI Gene ID		2908
neXtProt AC		NX_P04150
Human Synonyms		GCCR, GCR, GR, GRL
Human Chr (Location)		5q31.3; chr5:142657496-142815077 (-) GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NR3C1

Alleles
and
phenotypes

All alleles(14) : Targeted(13) Gene trapped(1)

Homozygous null mutants die at birth of respiratory failure with underdeveloped lungs, enlarged adrenals, elevated serum corticosterone and ACTH, and failed adrenaline synthesis. Mice with a point mutation have impaired gluconeogenesis and erythropoiesis.

Human Diseases Modeled Using Mouse Nr3c1 (1) Alleles Annotated to Human Diseases(1) Phenotype Images(1)

Gene Ontology
(GO)
classifications

All GO classifications: (71 annotations)

Process	adrenal gland development, cellular response to dexamethasone stimulus, ...
Component	cytoplasm, cytosol, ...
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (45 records)
Data Summary: Results (234) Tissues (162) Images (18)
Theiler Stages: 2, 3, 4, 5, 14, 15, 17, 19, 20, 21, 22, 23, 26, 28

Assay Type	Results
RNA in situ	151
Northern blot	18
Western blot	34
RT-PCR	31

cDNA source data(136)
External Resources: Allen Institute GENSAT GEO ArrayExpress

Molecular
reagents

All nucleic(157) Genomic(14) cDNA(137) Primer pair(6)
Microarray probesets(10)

Other database
links

VEGA Gene Model	OTTMUSG00000023975 (Evidence)
Ensembl Gene Model	ENSMUSG00000024431 (Evidence)
Entrez Gene	14815 (Evidence)
UniGene	129481
DFCI	TC1575767, TC1643837, TC1654882, TC1664672, TC1673805, TC1721538
DoTS	DT.101309837, DT.493344, DT.91401091, DT.99867367
NIA Mouse Gene Index	U038364
PDB	3MNE, 3MNO, 3MNP
Consensus CDS Project	CCDS37791.1
International Mouse Knockout Project Status	Nr3c1

Sequences

All sequences(82) RefSeq(2) UniProt(12)

Polymorphisms

RFLP(6) : SNPs(369 from dbSNP Build 128)

Protein-related
information

Resource	ID	Description
InterPro	IPR001409	Glucocorticoid receptor
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000011406	glucocorticoid receptor

References

(Earliest) J:6459 Francke U, et al., Chromosome assignment of a murine glucocorticoid receptor gene (Grl-1) using intraspecies somatic cell hybrids. Cell. 1980 Dec;22(3):657-64
(Latest) J:193397 Barik J, et al., Chronic stress triggers social aversion via glucocorticoid receptor in dopaminoceptive neurons. Science. 2013 Jan 18;339(6117):332-5
All references(262)

Other
accession IDs

MGD-MRK-10262, MGD-MRK-10263

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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