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Cxcr1 Gene Detail
Summary
  • Symbol
    Cxcr1
  • Name
    chemokine (C-X-C motif) receptor 1
  • Synonyms
    Il8ra
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448715
    NCBI Gene: 227288
Location & Maps
more
  • Sequence Map
    Chr1:74191785-74194631 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2847 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.44 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CXCR1, C-X-C motif chemokine receptor 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    CXCR1, C-X-C motif chemokine receptor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA
  • Links
    NCBI Gene ID: 3577
    neXtProt AC: NX_P25024

  • Chr Location
    2q35; chr2:218162845-218166993 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CXCR1 associations

Human Disease Mouse Models
       Human Immunodeficiency Virus Type 1, Susceptibility to   OMIM: 609423
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Cxcr1
  • Incidental Mutations
Mice homozygous for a gene disruption display normal morphology, clinical chemistry, hematology, and behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021550 VEGA Gene Model | MGI Sequence Detail 2847 C57BL/6J ±  kb
transcript OTTMUST00000122844 VEGA | MGI Sequence Detail 1451 Not Applicable  
polypeptide OTTMUSP00000067259 VEGA | MGI Sequence Detail 351 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    112 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR000174 CXC chemokine receptor 1/2
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 4
    cDNA 1
    Primer pair 1
    Other 2

    Microarray probesets 1
References
more
  • Summaries
    All 26
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:185240 Lefebvre S, et al., Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development. J Invest Dermatol. 2012 Apr;132(4):1094-102

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory