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Gria4
Gene Detail
 Symbol
Name
ID
Gria4
glutamate receptor, ionotropic, AMPA4 (alpha 4)
MGI:95811
Synonyms Glur4, Glur-4, Gluralpha4, spkw1
Feature Type protein coding gene
Genetic Map
Chromosome 9
2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr9:4417899-4796234 bp, - strand
From Ensembl annotation of GRCm38

  378336 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:20227  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken

Protein SuperFamily: ionotropic glutamate receptor, AMPA/kainate types
Gene Tree: Gria4
Human
homologs
Human Homolog GRIA4, glutamate receptor, ionotropic, AMPA 4
NCBI Gene ID 2893
neXtProt AC  NX_P48058
Human Synonyms  GluA4, GLUR4, GLUR4C, GLURD
Human Chr (Location)  11q22; chr11:105480800-105852819 (+)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(10) : Targeted(9) QTL(1)
 
Mice homozygous for a targeted mutation display hyperactivity, decreased thermal nociception, and abnormal sensitivity to pharmacologically induced seizures.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (32 annotations)
Process ionotropic glutamate receptor signaling pathway, ion transport, ...
Component alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex, cell junction, ...
Function alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity, extracellular-glutamate-gated ion channel activity, ...
External Resources: FuncBase
Expression Literature Summary: (10 records)
Data Summary: Results (329)    Tissues (149)    Images (34)
Theiler Stages: 17, 21, 23, 28
Assay TypeResults
RNA in situ 259
In situ reporter (knock in) 32
RT-PCR 38
cDNA source data(30)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(36) Genomic(1) cDNA(34) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000025892 (Evidence)
Entrez Gene14802 (Evidence)
UniGene209263
DFCITC1580146, TC1587971, TC1596069
DoTSDT.55178948, DT.91336086, DT.99848771
NIA Mouse Gene IndexU030434
Consensus CDS ProjectCCDS22797.1, CCDS52715.1, CCDS52716.1
International Mouse Knockout Project StatusGria4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025892 Ensembl Gene Model | MGI Sequence Detail 378336 C57BL/6J ±  kb
transcript ENSMUST00000027020 Ensembl | MGI Sequence Detail 5441 Not Applicable 
polypeptide ENSMUSP00000027020 Ensembl | MGI Sequence Detail 902 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(6) UniProt(7)
Polymorphisms RFLP(1) : SNPs(1584 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR019594 Glutamate receptor, L-glutamate/glycine-binding
InterPro IPR001320 Ionotropic glutamate receptor
InterPro IPR001508 NMDA receptor
Protein Ontology PR:000008236 glutamate receptor 4
References (Earliest) J:40449 Sommer B, et al., RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell. 1991 Oct 4;67(1):11-9
(Latest) J:191194 Huang LC, et al., Synaptic profiles during neurite extension, refinement and retraction in the developing cochlea. Neural Dev. 2012;7:38
All references(73)
Other
accession IDs 		MGD-MRK-10143, MGD-MRK-10150, MGD-MRK-10249, MGI:3580137
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory